FlyBase Allele Report: Dmel\Socs36E[GD8929]

General Information

Symbol

Dmel\Socs36E^GD8929

Species

D. melanogaster

Name

FlyBase ID

FBal0208569

Feature type

allele

Associated gene

Dmel\Socs36E

Associated Insertion(s)

Carried in Construct

P{GD8929}

Also Known As

UAS-socs36E^RNAi

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

(Dickson et al., 2007.7.18)

Progenitor genotype

Carried in construct

P{GD8929}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Dickson et al., 2007.7.18)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-GD8929

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of carcinoma

CEA with Egfr^UAS.cBa

(Xu et al., 2022, Groth et al., 2020, Herranz et al., 2012)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates tauopathy

modeled by Hsap\MAPT^UAS.cWa

(Colodner and Feany, 2010)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal size | third instar larval stage, with Scer\GAL4^ap-md544

(Herranz et al., 2012)

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

(Neely et al., 2010)

viable, with Scer\GAL4^tin.CΔ4

(Neely et al., 2010)

Phenotype Manifest In

photoreceptor cell R7 | increased number, with Scer\GAL4^GMR.PF

(Almudi et al., 2009)

photoreceptor cell R7 | increased number, with Scer\GAL4^hs.2sev

(Almudi et al., 2009)

wing disc dorsal compartment | third instar larval stage, with Scer\GAL4^ap-md544

(Herranz et al., 2012)

Detailed Description

Statement

Reference

Expressing Socs36E^GD8929 under the control of Scer\GAL4^ap-md544 results in a significantly larger wing disc dorsal compartment in third instar larvae compared to wild-type controls.

(Herranz et al., 2012)

Adults expressing Socs36E^GD8929 under the control of Scer\GAL4^elav.PLu (in the presence of Dcr-2^Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.

(Neely et al., 2010)

Flies expressing Socs36E^GD8929 under the control of Scer\GAL4^GMR.PF or Scer\GAL4^hs.2sev have extra R7 photoreceptor cells in some ommatidia.

(Almudi et al., 2009)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Egfr^UAS.cBa, Scer\GAL4^ap-md544, Socs36E^GD8929 has abnormal size | third instar larval stage phenotype, suppressible | partially by dome^ΔCYT.UAS, Scer\GAL4^ap-md544

(Herranz et al., 2012)

Egfr^UAS.cBa, Scer\GAL4^ap-md544, Socs36E^GD8929 has abnormal size | third instar larval stage phenotype, suppressible | partially by Stat92E^RNAi.UAS.cHa, Scer\GAL4^ap-md544

(Herranz et al., 2012)

Enhancer of

Statement

Reference

Socs36E^GD8929, Scer\GAL4^ap-md544 is an enhancer of abnormal size | third instar larval stage phenotype of Egfr^UAS.cBa, Scer\GAL4^ap-md544

(Herranz et al., 2012)

Socs36E^GD8929, Scer\GAL4^ap-md544 is an enhancer of abnormal size | third instar larval stage phenotype of Ras85D^V12.UAS, Scer\GAL4^ap-md544

(Herranz et al., 2012)

Suppressor of

Statement

Reference

Socs36E^GD8929/Scer\GAL4^Bx-MS1096 is a suppressor | partially of abnormal size | adult stage phenotype of Scer\GAL4^Bx-MS1096, mir-ban^{sponge.UAS.DsRed(Unk)}

(Herranz et al., 2012)

Scer\GAL80^ts.αTub84B, Socs36E^GD8929, Scer\GAL4^repo.PU is a suppressor | partially of increased cell death | adult stage phenotype of Hsap\MAPT^UAS.cWa, Scer\GAL4^repo.PU, Scer\GAL80^ts.αTub84B

(Colodner and Feany, 2010)

Other

Statement

Reference

Egfr^UAS.cBa, Scer\GAL4^ap-md544, Socs36E^GD8929 has abnormal size | somatic clone | third instar larval stage phenotype

(Herranz et al., 2012)

Egfr^UAS.cBa, Scer\GAL4^ap-md544, Socs36E^GD8929 has neoplasia phenotype

(Herranz et al., 2012)

Egfr^UAS.cBa, Scer\GAL4^ap-md544, Socs36E^GD8929 has abnormal planar polarity | third instar larval stage phenotype

(Herranz et al., 2012)

Egfr^UAS.cBa, Scer\GAL4^ap-md544, Socs36E^GD8929 has neoplasia | third instar larval stage phenotype

(Herranz et al., 2012)

Phenotype Manifest In

Suppressed by

Statement

Reference

Egfr^UAS.cBa, Scer\GAL4^ap-md544, Socs36E^GD8929 has wing disc dorsal compartment | third instar larval stage phenotype, suppressible | partially by dome^ΔCYT.UAS, Scer\GAL4^ap-md544

(Herranz et al., 2012)

Egfr^UAS.cBa, Scer\GAL4^ap-md544, Socs36E^GD8929 has wing disc dorsal compartment | third instar larval stage phenotype, suppressible | partially by Stat92E^RNAi.UAS.cHa, Scer\GAL4^ap-md544

(Herranz et al., 2012)

Enhancer of

Statement

Reference

Socs36E^GD8929, Scer\GAL4^ap-md544 is an enhancer of wing disc dorsal compartment | third instar larval stage phenotype of Egfr^UAS.cBa, Scer\GAL4^ap-md544

(Herranz et al., 2012)

Socs36E^GD8929, Scer\GAL4^ap-md544 is an enhancer of wing disc dorsal compartment | third instar larval stage phenotype of Ras85D^V12.UAS, Scer\GAL4^ap-md544

(Herranz et al., 2012)

Suppressor of

Statement

Reference

Socs36E^GD8929/Scer\GAL4^Bx-MS1096 is a suppressor | partially of wing phenotype of Scer\GAL4^ap-md544, mir-ban^{sponge.UAS.DsRed(Unk)}

(Herranz et al., 2012)

Scer\GAL80^ts.αTub84B, Socs36E^GD8929, Scer\GAL4^repo.PU is a suppressor | partially of adult brain phenotype of Hsap\MAPT^UAS.cWa, Scer\GAL4^repo.PU, Scer\GAL80^ts.αTub84B

(Colodner and Feany, 2010)

Other

Statement

Reference

Egfr^UAS.cBa, Scer\GAL4^ap-md544, Socs36E^GD8929 has wing disc | third instar larval stage phenotype

(Herranz et al., 2012)

Egfr^UAS.cBa, Scer\GAL4^ap-md544, Socs36E^GD8929 has wing disc | somatic clone | third instar larval stage phenotype

(Herranz et al., 2012)

Additional Comments

Genetic Interactions

Statement

Reference

Co-expressing Egfr^UAS.cBa with Socs36E^GD8929 under the control of Scer\GAL4^ap-md544 (in combination with a Gal80[ts] transgene to inhibit expression until early third instar) results in severely overgrown and deformed wing discs with a disrupted epithelial organization (resembling tissues undergoing a neoplastic transformation) in third instar larvae. Wing discs lose apico-basal polarity and cells metastasize invading other tissues of the larva. Transplanting wing disc fragments into the abdomens of adult hosts form tumors, grow rapidly, metastasize and kill the host flies.

Somatic clones co-expressing Egfr^UAS.cBa and Socs36E^GD8929 under the control of Scer\GAL4^ap-md544 in wing discs of third instar larvae overgrow, fuse and affect the shape of the disc.

(Herranz et al., 2012)

Xenogenetic Interactions

Statement

Reference

The increased number of apoptotic cells in the brain of adult flies expressing Hsap\MAPT^Scer\UAS.cWa under the control of Scer\GAL4^repo.PU (using tub-Gal80[ts] to minimize the transgene expression during development) is significantly reduced by co-expression of Socs36E^GD8929.

(Colodner and Feany, 2010)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

VDRC

v51821

w¹¹¹⁸; P{GD8929}v51821

v52182

w¹¹¹⁸; P{GD8929}v52182/CyO