FlyBase Allele Report: Dmel\dome[ΔCYT.UAS]

General Information

Symbol

Dmel\dome^ΔCYT.UAS

Species

D. melanogaster

Name

FlyBase ID

FBal0126406

Feature type

allele

Associated gene

Dmel\dome

Associated Insertion(s)

Carried in Construct

P{UAS-dome.ΔCYT}

Also Known As

UAS-dome^ΔCYT, UAS-domeΔCYT, UAS-dome^DN, dome^DN, DomeΔCYT, UAS-dome^ΔCYT3.2, UAS-dome.ΔCYT, UAS-dome^Δcyt2.1, UAS-dome^Δcyt1.1

Key Links

Transgenic product class

inframe_deletion

(Brown et al., 2001)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

inframe_deletion

(Brown et al., 2001)

Mutagen

in vitro construct

(Castelli-Gair Hombria, 2001.9.19)

Progenitor genotype

Carried in construct

P{UAS-dome.ΔCYT}

Cytology

Description

UAS regulatory sequences drive expression of a truncated form of dome which lacks the intracellular domain.

(Brown et al., 2001)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dome

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of viral infectious disease

CEA

(Merkling et al., 2015)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates cancer

modeled by Ras85D^V12.UAS, scrib¹

(Wu et al., 2010)

modeled by Ras85D^V12.UAS, upd1^UAS.cUa

(Wu et al., 2010)

modeled by scrib^HMS01490

(Bunker et al., 2015)

ameliorates carcinoma

modeled by Egfr^UAS.cBa, Socs36E^GD8929

(Herranz et al., 2012)

modeled by ph-d⁵⁰⁵, ph-p⁵⁰⁵

(Beira et al., 2018)

ameliorates hematologic cancer

modeled by hop^{UAS.ORF.Tag:HA}

(Terriente-Félix et al., 2017)

modeled by hop^Tum

(Bailetti et al., 2019)

Comments on Models/Modifiers Based on Experimental Evidence ( 1 )

In a tuberculosis model by abdominal injection with Mycobacterium marinum, adult flies expressing dome^{ΔCYT.Scer\UAS} under the control of Scer\GAL4^crq.Unk, in combination with gal80[ts] to restrict expression to adulthood, present a significant decrease in bacterial burden, as compared to wild-type control flies.

(Péan et al., 2017)

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal immune response, with Scer\GAL4^Act.PU

(Merkling et al., 2015)

abnormal immune response, with Scer\GAL4^crq.Unk

(Péan et al., 2017)

abnormal locomotor rhythm, with Scer\GAL4^dome-PG14

(Luo and Sehgal, 2012)

abnormal memory | adult stage | RU486 conditional, with Scer\GAL4^{Mef2.247.Switch}

(Copf et al., 2011)

abnormal size | adult stage, with Scer\GAL4^ey.PH

(Tsai and Sun, 2004)

abnormal size | larval stage, with Scer\GAL4^ap-md544

(Clemente-Ruiz et al., 2016)

abnormal size | third instar larval stage, with Scer\GAL4^ci.PU

(Recasens-Alvarez et al., 2017)

abnormal size | third instar larval stage, with Scer\GAL4^en-e16E

(Recasens-Alvarez et al., 2017)

abnormal size | third instar larval stage, with Scer\GAL4^hh.PU

(Recasens-Alvarez et al., 2017)

abnormal size | third instar larval stage, with Scer\GAL4^hth.PU

(Recasens-Alvarez et al., 2017)

abnormal size | third instar larval stage, with Scer\GAL4^sd.PU

(Recasens-Alvarez et al., 2017)

decreased fecundity, with Scer\GAL4^Myo31DF.PU

(Shianiou et al., 2023)

decreased occurrence of cell division | third instar larval stage, with Scer\GAL4^ey.PH

(Tsai and Sun, 2004)

increased cell death | third instar larval stage, with Scer\GAL4^en-e16E

(Recasens-Alvarez et al., 2017)

increased occurrence of cell division | adult stage, with Scer\GAL4^NP5130

(Jin et al., 2020)

short lived | conditional, with Scer\GAL4^Act.PU

(Merkling et al., 2015)

visible, with Scer\GAL4^ey.PH

(Tsai and Sun, 2004)

visible, with Scer\GAL4^ey.PU

(Karsten et al., 2006)

visible | adult stage, with Scer\GAL4^hth.PU

(Recasens-Alvarez et al., 2017)

Phenotype Manifest In

adult midgut epithelium | adult stage | somatic clone, with Scer\GAL4^Act.PU

(Jin et al., 2020)

border follicle cell, with Scer\GAL4^slbo.2.6

(Medioni and Noselli, 2005, Silver et al., 2005, Ghiglione et al., 2002, Silver and Montell, 2001)

egg chamber & basement membrane | apical, with Scer\GAL4^slbo.2.6

(Medioni and Noselli, 2005)

embryonic abdominal segment 4, with Scer\GAL4^{VP16.mat.αTub67C}

(Brown et al., 2001)

embryonic abdominal segment 5, with Scer\GAL4^{VP16.mat.αTub67C}

(Brown et al., 2001)

embryonic hindgut, with Scer\GAL4^byn-Gal4

(Wells et al., 2013, Johansen et al., 2003)

embryonic segment, with Scer\GAL4^{VP16.mat.αTub67C}

(Brown et al., 2001)

eye, with Scer\GAL4^ey.PH

(Tsai and Sun, 2004)

eye, with Scer\GAL4^ey.PU

(Karsten et al., 2006)

eye disc | somatic clone, with Scer\GAL4^Act.PU

(Classen et al., 2009)

eye disc anterior to the morphogenetic furrow, with Scer\GAL4^Eq

(Tsai and Sun, 2004)

intestinal stem cell of posterior adult midgut epithelium, with Scer\GAL4^esg.PU

(Zhou et al., 2013)

intestinal stem cell of posterior adult midgut epithelium, with Scer\GAL4^how-24B

(Zhou et al., 2013)

intestinal stem cell of posterior adult midgut epithelium, with Scer\GAL4^Su(H).GBE

(Zhou et al., 2013)

polar follicle cell, with Scer\GAL4^slbo.2.6

(Medioni and Noselli, 2005)

wing, with Scer\GAL4^hth.PU

(Recasens-Alvarez et al., 2017)

wing disc | third instar larval stage, with Scer\GAL4^sd.PU

(Recasens-Alvarez et al., 2017)

wing disc dorsal compartment, with Scer\GAL4^ap-md544

(Clemente-Ruiz et al., 2016)

wing disc posterior compartment | third instar larval stage, with Scer\GAL4^en-e16E

(Recasens-Alvarez et al., 2017)

wing disc posterior compartment | third instar larval stage, with Scer\GAL4^hh.PU

(Recasens-Alvarez et al., 2017)

wing disc posterior compartment | third instar larval stage, with Scer\GAL4^sd.PU

(Recasens-Alvarez et al., 2017)

wing hinge primordium | third instar larval stage, with Scer\GAL4^ci.PU

(Recasens-Alvarez et al., 2017)

wing pouch | third instar larval stage, with Scer\GAL4^hth.PU

(Recasens-Alvarez et al., 2017)

Detailed Description

Statement

Reference

Adulthood-generated midgut clones expressing dome^ΔCYT.UAS under the control of Scer\GAL4^Act.PU are composed of enteroblasts.

(Jin et al., 2020)

The expression of dome^{ΔCYT.Scer\UAS} under the control of Scer\GAL4^crq.Unk, in combination with gal80[ts] to restrict expression to adulthood, leads to a significant decrease in bacterial burden in adults infected with Mycobacterium marinum, as compared to wild-type controls.

(Péan et al., 2017)

The expression of dome^{ΔCYT.Scer\UAS} under the control of Scer\GAL4^sd.PU leads to a severe reduction in the overall size of the third instar larval wing disc, which is particularly evident on the posterior compartment (even occasionally leading to a complete loos of the compartment), as compared to controls. Expression under the control of Scer\GAL4^en-e16E or Scer\GAL4^hh.PU also leads to a severe decrease in size, the former also being associated with a severe increase in apoptosis, in the third instar larval wing disc posterior compartment, as compared to controls. Expression under the control of Scer\GAL4^ci.PU gives rise to a reduction in the presumptive hinge size, but does does not induce any ectopic wing structures, in third instar larval wing disc, as compared to controls. Expression under the control of Scer\GAL4^hth.PU leads to an expanded third instar larval wing pouch and to pattern duplications in the posterior compartment of the adult wing, as compared to controls.

(Recasens-Alvarez et al., 2017)

The expression of dome^ΔCYT.UAS under the control of Scer\GAL4^ap-md544 leads to a significant decrease in the size of the wing disc dorsal compartment, as compared to controls.

(Clemente-Ruiz et al., 2016)

Expression of dome^{ΔCYT.Scer\UAS} using Scer\GAL4^Act.PU increases mortality rates after infection with Drosophila C virus (DCV) compared with wild-type.

(Merkling et al., 2015)

Expression of dome^{ΔCYT.Scer\UAS} under the control of Scer\GAL4^byn-Gal4 results in stage 15 embryonic hindguts having a lower angle of curvature, as compared to controls.

(Wells et al., 2013)

Expression of dome^{ΔCYT.Scer\UAS} under the control of any of the following: Scer\GAL4^esg.PU, Scer\GAL4^Su(H).GBE or Scer\GAL4^how-24B significantly reduces the increase in the rate of intestinal stem cells division normally observed in the adult midgut upon bacterial infection challenge. The increase in division rate is not diminished when dome^{ΔCYT.Scer\UAS} is expressed under the control of either Scer\GAL4^Dl-05151-G or Scer\GAL4^Myo31DF.PU.

(Zhou et al., 2013)

Expression of dome^{ΔCYT.Scer\UAS} under the control of Scer\GAL4^tim.PE does not disrupt locomotor activity rhythms.

Expression of dome^{ΔCYT.Scer\UAS} under the control of Scer\GAL4^dome-PG14 results in defects in locomotor activity rhythms (only 15.4% of flies show rhythmic behaviour under constant darkness conditions).

(Luo and Sehgal, 2012)

Expression of dome^{ΔCYT.Scer\UAS} under the control of Scer\GAL4^{Mef2.247.Switch} specifically during the adult stage (in the presence of RU486) causes a defect in long term memory, without affecting anesthesia-resistant memory or short term memory.

(Copf et al., 2011)

Expression of dome^{ΔCYT.Scer\UAS} under the control of Scer\GAL4^Act.PU slightly decreases eye disc growth compared to wild type.

(Classen et al., 2009)

Expression of dome^{ΔCYT.Scer\UAS} under the control of Scer\GAL4^ey.PU results in a strong reduction in the overall volume of the eye and a loss of ventral eye tissue.

(Karsten et al., 2006)

Expression of dome^{ΔCYT.Scer\UAS} in border cells, driven by Scer\GAL4^slbo.2.6, induces most egg chambers to develop without outer border cells. Consequently, the two polar cells remain at the anterior tip and do not migrate. The apical cap forms normally in Scer\GAL4^slbo.2.6>dome^{ΔCYT.Scer\UAS} stage 9 egg chambers but is not shed in later stage egg chambers.

(Medioni and Noselli, 2005)

Expression of dome^{ΔCYT.Scer\UAS}, under the control of Scer\GAL4^slbo.2.6, causes slow migration of border cells. These cells often migrate as single cells rather than clusters.

(Silver et al., 2005)

Expression of dome^{ΔCYT.Scer\UAS} under the control of Scer\GAL4^ey.PH results in a small-eye phenotype.

Expression of dome^{ΔCYT.Scer\UAS} under the control of Scer\GAL4^Eq1 results in a reduction in the number of mitotic cells in the third instar larval eye disc in the first mitotic wave.

(Tsai and Sun, 2004)

Expression of dome^{ΔCYT.Scer\UAS} under the control of Scer\GAL4^byn-Gal4 results in embryos with significantly shorter and wider hindguts than normal. There are a greater number of cells in the circumference of the mutant hindgut than in wild type.

(Johansen et al., 2003)

Egg chambers expressing dome^{ΔCYT.Scer\UAS} under the control of Scer\GAL4^slbo.2.6 lack outer border follicle cells.

(Ghiglione et al., 2002)

Expression of dome^{ΔCYT.Scer\UAS} under the control of Scer\GAL4^{mat.αTub67C.T:Hsim\VP16} results in segmentation defects in approximately 50% of embryos. The most frequent defects are deletions and fusions of segments A4 and A5.

(Brown et al., 2001)

When dome^{ΔCYT.Scer\UAS} is driven by Scer\GAL4^slbo.2.6, dramatic recruitment and migration defects in the border cells are observed. The average number of outer border cells in these egg chambers is 0.5.

(Silver and Montell, 2001)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Scer\GAL4^NP5130, dome^ΔCYT.UAS has increased occurrence of cell division | adult stage phenotype, suppressible by Scer\GAL4^NP5130/Sox100B^{UAS.ORF.GW.Tag:HA}

(Jin et al., 2020)

Scer\GAL4^en-e16E, dome^ΔCYT.UAS has abnormal size | third instar larval stage phenotype, suppressible | partially by Diap1^{UAS.Tag:MYC.cBa}, Scer\GAL4^en-e16E

(Recasens-Alvarez et al., 2017)

Scer\GAL4^en-e16E, dome^ΔCYT.UAS has abnormal size | third instar larval stage phenotype, suppressible | partially by CycA^UAS.cWa, Scer\GAL4^en-e16E

(Recasens-Alvarez et al., 2017)

Scer\GAL4^en-e16E, dome^ΔCYT.UAS has abnormal size | third instar larval stage phenotype, suppressible | partially by Dronc^GD12376, Scer\GAL4^en-e16E

(Recasens-Alvarez et al., 2017)

Scer\GAL4^en-e16E, dome^ΔCYT.UAS has increased cell death | third instar larval stage phenotype, suppressible | partially by Diap1^{UAS.Tag:MYC.cBa}, Scer\GAL4^en-e16E

(Recasens-Alvarez et al., 2017)

Scer\GAL4^en-e16E, dome^ΔCYT.UAS has increased cell death | third instar larval stage phenotype, suppressible | partially by Dronc^GD12376, Scer\GAL4^en-e16E

(Recasens-Alvarez et al., 2017)

Scer\GAL4^en-e16E, dome^ΔCYT.UAS has abnormal size | third instar larval stage phenotype, suppressible | partially by Scer\GAL4^en-e16E/en^JF02316

(Recasens-Alvarez et al., 2017)

Scer\GAL4^en-e16E, dome^ΔCYT.UAS has abnormal size | third instar larval stage phenotype, suppressible | partially by en^KK107874/Scer\GAL4^en-e16E

(Recasens-Alvarez et al., 2017)

Scer\GAL4^en-e16E, dome^ΔCYT.UAS has abnormal size | third instar larval stage phenotype, suppressible by Df(2R)en^E/+

(Recasens-Alvarez et al., 2017)

Scer\GAL4^en-e16E, dome^ΔCYT.UAS has increased cell death | third instar larval stage phenotype, suppressible | partially by en^KK107874/Scer\GAL4^en-e16E

(Recasens-Alvarez et al., 2017)

Scer\GAL4^en-e16E, dome^ΔCYT.UAS has abnormal size | third instar larval stage phenotype, suppressible | partially by BacA\p35^UAS.cHa, Scer\GAL4^en-e16E

(Recasens-Alvarez et al., 2017)

NOT suppressed by

Statement

Reference

Scer\GAL4^en-e16E, dome^ΔCYT.UAS has abnormal size | third instar larval stage phenotype, non-suppressible by CycB^UAS.Tag:HA, Scer\GAL4^en-e16E

(Recasens-Alvarez et al., 2017)

NOT Enhancer of

Statement

Reference

dome^ΔCYT.UAS/Scer\GAL4^Act.PU is a non-enhancer of abnormal immune response phenotype of G9a^DD2

(Merkling et al., 2015)

dome^ΔCYT.UAS/Scer\GAL4^Act.PU is a non-enhancer of short lived | conditional phenotype of G9a^DD2

(Merkling et al., 2015)

Suppressor of

Statement

Reference

dome^ΔCYT.UAS, Scer\GAL4^ap-md544 is a suppressor of abnormal developmental rate phenotype of BacA\p35^UAS.cHa, Bub3^GD9924, Scer\GAL4^ap-md544

(Romão et al., 2021)

dome^ΔCYT.UAS, Scer\GAL4^ap-md544 is a suppressor of abnormal size | larval stage phenotype of BacA\p35^UAS.cHa, Bub3^GD9924, Scer\GAL4^ap-md544

(Clemente-Ruiz et al., 2016)

dome^ΔCYT.UAS/Scer\GAL4^Bx-MS1096 is a suppressor of neoplasia | third instar larval stage phenotype of Scer\GAL4^Bx-MS1096, scrib^HMS01490

(Bunker et al., 2015)

dome^ΔCYT.UAS, Scer\GAL4^ap-md544 is a suppressor | partially of abnormal size | third instar larval stage phenotype of Egfr^UAS.cBa, Scer\GAL4^ap-md544, Socs36E^GD8929

(Herranz et al., 2012)

dome^ΔCYT.UAS, Scer\GAL4^Act.PU is a suppressor of neoplasia | somatic clone phenotype of Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib¹

(Wu et al., 2010)

dome^ΔCYT.UAS, Scer\GAL4^Act.PU is a suppressor of neoplasia | somatic clone phenotype of Ras85D^V12.UAS, Scer\GAL4^Act.PU, upd1^UAS.cUa

(Wu et al., 2010)

dome^ΔCYT.UAS/Scer\GAL4^Act.PU is a suppressor of neoplasia | somatic clone phenotype of Pc¹⁵

(Classen et al., 2009)

dome^ΔCYT.UAS/Scer\GAL4^Act.PU is a suppressor of neoplasia | somatic clone phenotype of Sce¹

(Classen et al., 2009)

dome^ΔCYT.UAS/Scer\GAL4^ey.PH is a suppressor of abnormal size phenotype of L^fee

(Wang and Huang, 2009)

NOT Suppressor of

Statement

Reference

dome^ΔCYT.UAS/Scer\GAL4^NP7397 is a non-suppressor of increased occurrence of cell division | adult stage phenotype of Scer\GAL4^NP7397, Src64B^UY1332

(Kohlmaier et al., 2015)

dome^ΔCYT.UAS/Scer\GAL4^Act.PU is a non-suppressor of abnormal immune response phenotype of G9a^DD2

(Merkling et al., 2015)

dome^ΔCYT.UAS/Scer\GAL4^Act.PU is a non-suppressor of short lived | conditional phenotype of G9a^DD2

(Merkling et al., 2015)

dome^ΔCYT.UAS/Scer\GAL4^FRT.Act5C is a non-suppressor of increased cell number phenotype of elB^3.3.1, noc^d64

(Luque and Milan, 2007)

dome^ΔCYT.UAS/Scer\GAL4^FRT.Act5C is a non-suppressor of neoplasia | adult stage phenotype of elB^3.3.1, noc^d64

(Luque and Milan, 2007)

Phenotype Manifest In

Enhanced by

Statement

Reference

Scer\GAL4^{VP16.mat.αTub67C}, dome^ΔCYT.UAS has embryonic segment phenotype, enhanceable by hop^unspecified

(Brown et al., 2001)

Suppressed by

Statement

Reference

Scer\GAL4^Act.PU, dome^ΔCYT.UAS has adult midgut epithelium | somatic clone phenotype, suppressible by Scer\GAL4^Act.PU/Sox100B^{UAS.ORF.GW.Tag:HA}

(Jin et al., 2020)

Scer\GAL4^en-e16E, dome^ΔCYT.UAS has wing disc posterior compartment | third instar larval stage phenotype, suppressible | partially by Diap1^{UAS.Tag:MYC.cBa}, Scer\GAL4^en-e16E

(Recasens-Alvarez et al., 2017)

Scer\GAL4^en-e16E, dome^ΔCYT.UAS has wing disc posterior compartment | third instar larval stage phenotype, suppressible | partially by CycA^UAS.cWa, Scer\GAL4^en-e16E

(Recasens-Alvarez et al., 2017)

Scer\GAL4^en-e16E, dome^ΔCYT.UAS has wing disc posterior compartment | third instar larval stage phenotype, suppressible | partially by Dronc^GD12376, Scer\GAL4^en-e16E

(Recasens-Alvarez et al., 2017)

Scer\GAL4^en-e16E, dome^ΔCYT.UAS has wing disc posterior compartment | third instar larval stage phenotype, suppressible | partially by Scer\GAL4^en-e16E/en^JF02316

(Recasens-Alvarez et al., 2017)

Scer\GAL4^en-e16E, dome^ΔCYT.UAS has wing disc posterior compartment | third instar larval stage phenotype, suppressible | partially by en^KK107874/Scer\GAL4^en-e16E

(Recasens-Alvarez et al., 2017)

Scer\GAL4^en-e16E, dome^ΔCYT.UAS has wing disc posterior compartment | third instar larval stage phenotype, suppressible | partially by Df(2R)en^E/+

(Recasens-Alvarez et al., 2017)

Scer\GAL4^en-e16E, dome^ΔCYT.UAS has wing disc posterior compartment | third instar larval stage phenotype, suppressible | partially by BacA\p35^UAS.cHa, Scer\GAL4^en-e16E

(Recasens-Alvarez et al., 2017)

NOT suppressed by

Statement

Reference

Scer\GAL4^en-e16E, dome^ΔCYT.UAS has wing disc posterior compartment | third instar larval stage phenotype, non-suppressible by CycB^UAS.Tag:HA, Scer\GAL4^en-e16E

(Recasens-Alvarez et al., 2017)

Suppressor of

Statement

Reference

dome^ΔCYT.UAS, Scer\GAL4^Act.PU is a suppressor | somatic clone of autophagosome | somatic clone | cell non-autonomous | third instar larval stage phenotype of Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib⁶⁷³

(Katheder et al., 2017)

(Katheder et al., 2017)

dome^ΔCYT.UAS, Scer\GAL4^ap-md544 is a suppressor of wing disc dorsal compartment phenotype of BacA\p35^UAS.cHa, Bub3^GD9924, Scer\GAL4^ap-md544

(Clemente-Ruiz et al., 2016)

dome^ΔCYT.UAS/Scer\GAL4^Bx-MS1096 is a suppressor of wing disc | third instar larval stage phenotype of Scer\GAL4^Bx-MS1096, scrib^HMS01490

(Bunker et al., 2015)

dome^ΔCYT.UAS, Scer\GAL4^ap-md544 is a suppressor | partially of wing disc dorsal compartment | third instar larval stage phenotype of Egfr^UAS.cBa, Scer\GAL4^ap-md544, Socs36E^GD8929

(Herranz et al., 2012)

dome^ΔCYT.UAS, Scer\GAL4^Act.PU is a suppressor of eye disc | somatic clone phenotype of Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib¹

(Wu et al., 2010)

dome^ΔCYT.UAS, Scer\GAL4^Act.PU is a suppressor of eye disc | somatic clone phenotype of Ras85D^V12.UAS, Scer\GAL4^Act.PU, upd1^UAS.cUa

(Wu et al., 2010)

dome^ΔCYT.UAS/Scer\GAL4^Act.PU is a suppressor of eye disc | somatic clone phenotype of Pc¹⁵

(Classen et al., 2009)

dome^ΔCYT.UAS/Scer\GAL4^Act.PU is a suppressor of eye disc | somatic clone phenotype of Sce¹

(Classen et al., 2009)

dome^ΔCYT.UAS/Scer\GAL4^ey.PH is a suppressor of eye phenotype of L^fee

(Wang and Huang, 2009)

dome^ΔCYT.UAS/Scer\GAL4^slbo.2.6 is a suppressor of border follicle cell | increased number phenotype of Scer\GAL4^slbo.2.6, upd1^UAS.cZa

(Ghiglione et al., 2002)

NOT Suppressor of

Statement

Reference

dome^ΔCYT.UAS/Scer\GAL4^NP7397 is a non-suppressor of adult midgut phenotype of Scer\GAL4^NP7397, Src64B^UY1332

(Kohlmaier et al., 2015)

dome^ΔCYT.UAS/Scer\GAL4^FRT.Act5C is a non-suppressor of eye-antennal disc | somatic clone phenotype of elB^3.3.1, noc^d64

(Luque and Milan, 2007)

dome^ΔCYT.UAS/Scer\GAL4^FRT.Act5C is a non-suppressor of adult head capsule | somatic clone phenotype of elB^3.3.1, noc^d64

(Luque and Milan, 2007)

Additional Comments

Genetic Interactions

Statement

Reference

The cell non-autonomous increase in autophagosomes (assessed by a Atg8a fluorescence reporter) in neighboring tissue resulting from the presence of clones homozygous for scrib⁶⁷³ and expressing Ras85D^V12.Scer\UAS under the control of Scer\GAL4^Act.PU in third instar larval eye-antennal imaginal discs is suppressed by the additional clonal co-expression of dome^{ΔCYT.Scer\UAS}.

(Katheder et al., 2017)

The severe decrease in wing disc posterior compartment size induced by the expression of dome^{ΔCYT.Scer\UAS} under the control of Scer\GAL4^en-e16E is partially suppressed by heterozygosity for Df(2R)en^E, or by the co-expression of Diap1^{Scer\UAS.T:Hsap\MYC.cBa}, Dronc^GD12376, CycA^Scer\UAS.cWa, en^JF02316 or en^KK107874, but not by the co-expression of CycB^{Scer\UAS.T:Ivir\HA1}; the associated severe increase in apoptosis in the posterior compartment is also suppressed by the co-expression of Diap1^{Scer\UAS.T:Hsap\MYC.cBa}, Dronc^GD12376 or en^KK107874.

(Recasens-Alvarez et al., 2017)

The co-expression of dome^{ΔCYT.Scer\UAS} suppresses the tumor phenotype induced by the expression of scrib^HMS01490 under the control of Scer\GAL4^Bx-MS1096.

(Bunker et al., 2015)

Expression of dome^{ΔCYT.Scer\UAS} suppresses the overgrowth and invasion of the nerve cord seen in scrib¹ mutant eye-antennal disc clones that simultaneously express Ras85D^V12.Scer\UAS under the control of Scer\GAL4^Act.PU.

Expression of dome^{ΔCYT.Scer\UAS} in eye-antennal disc clones that express Ras85D^V12.Scer\UAS under the control of Scer\GAL4^Act.PU, and in which adjacent cells are mutant for scrib¹, suppresses the overgrowth and invasion of the nerve cord.

Expression of dome^{ΔCYT.Scer\UAS} in eye-antennal disc clones that express Ras85D^V12.Scer\UAS and upd1^Scer\UAS.cUa under the control of Scer\GAL4^Act.PU suppresses the overgrowth and invasion of the nerve cord.

(Wu et al., 2010)

Expression of dome^{ΔCYT.Scer\UAS} under the control of Scer\GAL4^Act.PU reduces the overgrowth of Sce¹ and of Pc¹⁵ mutant eye discs.

(Classen et al., 2009)

Expression of dome^{ΔCYT.Scer\UAS} under the control of Scer\GAL4^ey.PH in a L^fee mutant background restores eye size to normal.

(Wang and Huang, 2009)

The frequency of overgrowths observed in elB^3.3.1 noc^d64 double mutant ey clones is not affected when the JAK-STAT pathway is blocked by expression of dominant-negative dome^{ΔCYT.Scer\UAS} (under the control of Scer\GAL4^{Scer\FRT.Act5C}).

(Luque and Milan, 2007)

Co-expression of dome^{ΔCYT.Scer\UAS} completely suppresses the extra border follicle cells produced by expression of upd1^Scer\UAS.cZa under the control of Scer\GAL4^slbo.2.6.

(Ghiglione et al., 2002)

The penetrance and expressivity of the segmentation defects of embryos expressing dome^{ΔCYT.Scer\UAS} under the control of Scer\GAL4^{mat.αTub67C.T:Hsim\VP16} is enhanced if the mothers are also heterozygous for hop^unspecified.

(Brown et al., 2001)

Xenogenetic Interactions

Statement

Reference

(Recasens-Alvarez et al., 2017)

The co-expression of Bub3^GD9924 and BacA\p35^UAS.cHa under the control of Scer\GAL4^ap-md544 leads to a significant increase in the size of the wing disc dorsal compartment, as compared to controls; this phenotype is suppressed by the co-expression of dome^ΔCYT.UAS.

(Clemente-Ruiz et al., 2016)

Complementation and Rescue Data

Rescues

dome^ΔCYT.UAS/Scer\GAL4^ci.PU rescues dome^HMS01293

(Recasens-Alvarez et al., 2017)

Fails to rescue

dome^ΔCYT.UAS/Scer\GAL4^unspecified fails to rescue dome^unspecified

(Brown et al., 2001)

Comments

The co-expression of dome^{ΔCYT.Scer\UAS} suppresses the non-autonomous induction of ectopic wing structures in third instar larval wing discs resulting from the expression of dome^HMS01293 under the control of Scer\GAL4^ci.PU.

(Recasens-Alvarez et al., 2017)

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Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (7)

Reported As

Symbol Synonym

Dome Δcyt

(Medioni and Noselli, 2005)

Dome^DN

(Dong et al., 2021)

Dome^ΔCYT

(Dostert et al., 2005)

DomeΔCYT

(Classen et al., 2009)

dome^DN

(Katheder et al., 2017)

dome^{ΔCYT.Scer\UAS}

dome^ΔCYT.UAS

Name Synonyms

Secondary FlyBase IDs

References (57)

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