FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Scer\GAL4NP5130
Open Close
General Information
Symbol
Scer\GAL4NP5130
Species
S. cerevisiae
Name
FlyBase ID
FBal0098823
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
esg-GAL4, esgGal4, escargot-gal4, NP5130, esgGal4NP5130, Esg-GAL4NP5130, esg::Gal4
Genomic Maps

Allele class
Nature of the Allele
Allele class
Progenitor genotype
Associated Insertion(s)
Cytology
Description
Allele components
Component
Use(s)
Inserted element
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
(Wang et al., 2026, Ding et al., 2025, Liu et al., 2025, Xiao et al., 2025, Zhu et al., 2025, Gao et al., 2024, Nagai et al., 2024, Vonolfen et al., 2024, Zhang et al., 2024, Jneid et al., 2023, Joshi et al., 2023, Karuparti et al., 2023, Loudhaief et al., 2023, Nagai et al., 2023, Saavedra et al., 2023, Socha et al., 2023, Wu et al., 2023, Xu et al., 2023, Xu et al., 2023, Buddika et al., 2022, Chen et al., 2022, Chen et al., 2022, Kaur et al., 2022, Liu et al., 2022, Liu et al., 2022, Mukherjee et al., 2022, Neophytou and Pitsouli, 2022, Wang and Spradling, 2022, Zhao et al., 2022, Buddika et al., 2021, Ding et al., 2021, Jin et al., 2021, Kim et al., 2021, Koreman et al., 2021, Lu et al., 2021, Mok and Choi, 2021, Mukherjee et al., 2021, Nagai et al., 2021, Nászai et al., 2021, Nirala et al., 2021, Parkhitko et al., 2021, Resnik-Docampo et al., 2021, Tamamouna et al., 2021, Tang et al., 2021, Wu et al., 2021, Zhao et al., 2021, Arnaoutov et al., 2020, Bajpai et al., 2020, Iijima et al., 2020, Jin et al., 2020, Meng et al., 2020, Upadhyay et al., 2020, Weaver et al., 2020, Xu et al., 2020, Gultekin and Steller, 2019, Nakano et al., 2019, Song et al., 2019, Wang et al., 2019, Xu et al., 2019, Harsh et al., 2018, Iatsenko et al., 2018, Obata et al., 2018, Petrovsky and Großhans, 2018, Xu et al., 2018, Yin and Xi, 2018, Zhai et al., 2018, McClelland et al., 2017, Ngo et al., 2017, Requena et al., 2017, Tian et al., 2017, Zhai et al., 2017, Nagy et al., 2016, Singh et al., 2016, Wang et al., 2016, Beehler-Evans and Micchelli, 2015, Jin et al., 2015, Kwon et al., 2015, Liu et al., 2015, Lu and Li, 2015, Meng and Biteau, 2015, Nie et al., 2015, Park et al., 2015, Wang et al., 2015, Yu et al., 2015, Zhai et al., 2015, Banerjee and Chinthapalli, 2014, Berns et al., 2014, Biteau and Jasper, 2014, Cordero et al., 2014, Huang et al., 2014, Huang et al., 2014, Markstein et al., 2014, Montagne and Gonzalez-Gaitan, 2014, Song et al., 2014, Wang et al., 2014, Yu et al., 2014, Buchon et al., 2013, Guo et al., 2013, Hatini et al., 2013, Jin et al., 2013, Karpac et al., 2013, Kwon et al., 2013, Lee et al., 2013, Lin et al., 2013, Ma et al., 2013, Pitsouli and Perrimon, 2013, Quan et al., 2013, Roti et al., 2013, Tang et al., 2013, Wang et al., 2013, Bangi et al., 2012, Bond and Foley, 2012, Foronda et al., 2012, Osman et al., 2012, Glittenberg et al., 2011, Lee et al., 2011, Narbonne-Reveau et al., 2011, Biteau et al., 2010, Buchon et al., 2010, Ngo et al., 2010, Ninov et al., 2010, Park et al., 2010, Pitsouli and Perrimon, 2010, Ren et al., 2010, Wang et al., 2010, Zeng et al., 2010, Buchon et al., 2009, Chatterjee and Ip, 2009, Cronin et al., 2009, Lee et al., 2009, McKay et al., 2009, Choi et al., 2008, Villányi et al., 2008, Zmojdzian et al., 2008, Ninov et al., 2007, Martin and Morata, 2006, Micchelli and Perrimon, 2006, Venkei et al., 2006, Kondoh et al., 2003, Lee and Kolodziej, 2002, Goto and Hayashi, 1999)
Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
distribution deduced from reporter
Stage
Tissue/Position (including subcellular localization)
Reference
distribution deduced from reporter (Gal4 UAS)
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Information
Statement
Reference

Drives expression in histoblasts and histoblast nests, in enteroblasts, and in intestinal stem cells.

ScerGAL4esg-NP5130 drives expression in abdominal histoblast nests and histoblasts, but not in cuticular larval epidermal cells.

ScerGAL4esg-NP5130 expression is observed in 36% of small cells that occupy a basal position within the adult midgut epithelium.

About half of esg-positive (ScerGAL4esg-NP5130 expression) cells lack N signalling (do not express EcollacZDdc.be2.E(spl)m8-HLH); these exhibit characteristics of intestinal stem cells and enteroblasts.

Expression in second instar leg discs is excluded from the distal-most regions. Third instar expression is observed in the proximal region of the leg discs.

 
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference
External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
NOT Enhanced by
Suppressed by
Statement
Reference

Scer\GAL4NP5130, Src42ACA.UAS has hyperplasia phenotype, suppressible by Egfr[+]/Egfrt1

NOT suppressed by
Statement
Reference
Enhancer of
NOT Enhancer of
Suppressor of
Statement
Reference
NOT Suppressor of
Statement
Reference
Phenotype Manifest In
Enhanced by
Statement
Reference
NOT Enhanced by
Suppressed by
Statement
Reference
NOT suppressed by
Statement
Reference
Enhancer of
Statement
Reference
NOT Enhancer of
Suppressor of
Statement
Reference
NOT Suppressor of
Statement
Reference
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Images (0)
Mutant
Wild-type
Stocks (11)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (4)
Reported As
Symbol Synonym
GAL4esg-NP5130
Scer\GAL4NP5130
Scer\GAL4esg-NP5130
Name Synonyms
Secondary FlyBase IDs
    References (143)