FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\sip3UAS.Tag:MYC
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General Information
Symbol
Dmel\sip3UAS.Tag:MYC
Species
D. melanogaster
Name
FlyBase ID
FBal0241807
Feature type
allele
Associated gene
Dmel\sip3
Associated Insertion(s)
Carried in Construct
P{UAS-Hrd1.Myc}
Also Known As
UAS-Hrd1
Key Links
Transgenic product class
wild_type
(Kang and Ryoo, 2009)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Kang and Ryoo, 2009)
Mutagen
in vitro construct
(Kang and Ryoo, 2009)
Progenitor genotype
Carried in construct
P{UAS-Hrd1.Myc}
Cytology
Description

UAS regulatory sequences drive expression of sip3 which is tagged at the N-terminal end with Tag:MYC.

(Kang and Ryoo, 2009)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
sip3
Tagged with
Tag:MYC
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  retinitis pigmentosa
      modeled by ninaEG69D.GMR
      (Huang et al., 2018)
      modeled by ninaEG69D
      (Kang and Ryoo, 2009)
      ameliorates  retinal disease
      modeled by ninaEG69D
      (Xu et al., 2020)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The expression throughout development of sip3UAS.Tag:MYC under the control of Scer\GAL4NP5130 leads to a significant decrease in the proportion of mitotic cell in the midguts of 25- to 55-days old adults, as compared to controls; clonal expression under the control of Scer\GAL4unspecified in adult midgut clones results in a significant decrease in the average clone cell number at 7 days after clone induction, as compared to control clones.

      (Wang et al., 2014)

      Expression of sip3Scer\UAS.T:Hsap\MYC under the control of Scer\GAL4ninaE.PT does not result in retinal degeneration (as determined using the pseudopupil assay).

      (Kang and Ryoo, 2009)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The abnormal eye morphology resulting from the expression of ninaEG69D.GMR under the combined control of Scer\GAL4GMR.PU, Scer\GAL4ey.PU is suppressed by the co-expression of sip3Scer\UAS.T:Hsap\MYC alone, but not by co-expression of sip3Scer\UAS.T:Hsap\MYC in combination with sip3GD3145, CG32441KK104001, PnglKK101641, CG11070KK101530, asrijKK108914, CG2126GD3969, hiroKK101387 or CG6766GD5521 (in combination with Dicer-2, for efficient RNAi).

      (Huang et al., 2018)

      Expression of sip3Scer\UAS.T:Hsap\MYC or under the control of Scer\GAL4ninaE.PT dramatically decreases the rate of pseudopupil loss seen in ninaEG69D/+ flies. The ommatidial defects seen in 21 day old ninaEG69D/+ flies are also suppressed in the double mutants.

      (Kang and Ryoo, 2009)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      sip3Scer\UAS.T:Hsap\MYC
      sip3UAS.Tag:MYC
      Name Synonyms
      Secondary FlyBase IDs
        References (6)