FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
Allele: Dmel\upd3UASp.cZa
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General Information
Symbol
Dmel\upd3UASp.cZa
Species
D. melanogaster
Name
FlyBase ID
FBal0321390
Feature type
allele
Associated gene
Dmel\upd3
Associated Insertion(s)
Carried in Construct
P{UASp-upd3.Z}
Also Known As
UAS-Upd3
Key Links
Transgenic product class
cDNA
(Zhou et al., 2013)
wild_type
(Zhou et al., 2013)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Zhou et al., 2013)
wild_type
(Zhou et al., 2013)
Mutagen
in vitro construct
(Zhou et al., 2013)
Progenitor genotype
Carried in construct
P{UASp-upd3.Z}
Cytology
Description

UASp regulatory sequences drive expression of a upd3 cDNA.

(Zhou et al., 2013)
Allele components
Component
Use(s)
Regulatory region(s)
UASp
Encoded product / tool
upd3
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of upd3Scer\UAS.P\T.cZa under the control of Scer\GAL4esg-NP5130 (in combination with a Gal80[ts] transgene to restrict expression to the adult stage) results in a significant increase in the number of mitotic cells in the midgut, as compared to controls.

      (Nie et al., 2015)

      Expression of upd3Scer\UAS.P\T.cZa under the control of Scer\GAL4upd3.PZ (using tub-Gal80[ts] to limit the stage of expression) results in an increase in the rate of intestinal stem cells division in the adult midgut.

      (Zhou et al., 2013)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Co-expression of bunGD1392 or MadmGD7155 suppresses the increased number of mitotic cells seen in the midguts of flies expressing upd3Scer\UAS.P\T.cZa under the control of Scer\GAL4esg-NP5130.

      (Nie et al., 2015)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      Scer\GAL4upd3.PZ/upd3UASp.cZa rescues upd3Δ9

      (Zhou et al., 2013)
      Comments

      The failure of upd3Δ9 homozygote adults to increase the rate of intestinal stem cells division upon challenge by bacterial infection in the midgut (as is normally seen in wild-type) is rescued by expression of upd3Scer\UAS.P\T.cZa under the control of Scer\GAL4upd3.PZ (using tub-Gal80[ts] to limit the stage of expression).

      (Zhou et al., 2013)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      upd3Scer\UAS.P\T.cZa
      upd3UASp.cZa
      Name Synonyms
      Secondary FlyBase IDs
        References (3)