FB2026_02 , released June 18, 2026
Allele: Dmel\upd3Δ9
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General Information
Symbol
Dmel\upd3Δ9
Species
D. melanogaster
Name
FlyBase ID
FBal0321389
Feature type
allele
Associated gene
Dmel\upd3
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
Delta2-3 transposase
(Zhou et al., 2013)
Progenitor genotype
P{XP}upd3d00871
(Zhou et al., 2013)
Cytology
Description

Deletion within upd3 that extends from +3476 to +6706 relative to the start codon. This is predicted to produce a truncated polypeptide consisting of the first 217 amino acids of upd3 plus 7 C-terminal amino acid residues.

(Zhou et al., 2013)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
X:18,281,078..18,284,308 [+]
Comment:

Deletion resulting from the imprecise excision of P{XP}upd3d00871 which removes sequences between +3476 and +6706 relative to the ATG start codon.

(Zhou et al., 2013)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      upd3Δ9 homozygotes are viable and display increased longevity compared to wild-type controls. However, the increase in the rate of intestinal stem cells (ISC) division in the midgut in response to bacterial infection observed in wild-type controls does not occur in upd3Δ9 homozygote adults.

      (Zhou et al., 2013)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      upd3Δ9 is rescued by Scer\GAL4upd3.PZ/upd3UASp.cZa

      (Zhou et al., 2013)
      Comments

      The failure of upd3Δ9 homozygote adults to increase the rate of intestinal stem cells division upon challenge by bacterial infection in the midgut (as is normally seen in wild-type) is rescued by expression of upd3Scer\UAS.P\T.cZa under the control of Scer\GAL4upd3.PZ (using tub-Gal80[ts] to limit the stage of expression).

      (Zhou et al., 2013)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      upd3Delta9
      (Winkler et al., 2025)
      upd3Δ9
      Δupd3#9
      (Zhou et al., 2013)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)