FlyBase Gene Report: Dmel\upd3

General Information

Symbol

Dmel\upd3

Species

D. melanogaster

Name

unpaired 3

Annotation Symbol

CG33542

Feature Type

protein_coding_gene

FlyBase ID

FBgn0053542

Gene Model Status

Stock Availability

36 publicly available

Gene Summary

unpaired 3 (upd3) encodes a "cytokine" (secreted protein) of the Unpaired family that can bind and activate the JAK-STAT receptor encoded by dome. It is induced in hemocytes or in the intestine upon damage to regulate the repair response in these tissues through JAK-STAT activation. [Date last reviewed: 2019-03-21] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Pathway
Gene Group
Interactive Fly

Also Known As

os, Upd, upd-3, Upd-like, outstretched

Key Links

Genomic Location

Cytogenetic map

Sequence location

X:18,277,233..18,284,596 [+]

Recombination map

1-60

RefSeq locus

NC_004354 REGION:18277233..18284596

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (10 terms)

Molecular Function (1 term)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

enables cytokine activity

inferred from direct assay

(Oldefest et al., 2013, Wright et al., 2011)

Terms Based on Predictions or Assertions (0 terms)

Biological Process (8 terms)

Terms Based on Experimental Evidence (6 terms)

CV Term

Evidence

References

involved_in intestinal epithelial structure maintenance

inferred from mutant phenotype

(Osman et al., 2012)

involved_in intestinal stem cell homeostasis

inferred from mutant phenotype

(Zhou et al., 2013)

involved_in oogenesis

inferred from mutant phenotype

(Wang et al., 2014)

involved_in paracrine signaling

inferred from direct assay

(Wright et al., 2011)

involved_in positive regulation of cell population proliferation

inferred from mutant phenotype

(Buchon et al., 2010)

involved_in receptor signaling pathway via JAK-STAT

inferred from mutant phenotype

(Zhou et al., 2013, Osman et al., 2012, Wright et al., 2011, Wawersik et al., 2005)

inferred from genetic interaction with FLYBASE:hop; FB:FBgn0004864

(Bailetti et al., 2019, Wright et al., 2011)

inferred from direct assay

(Oldefest et al., 2013, Wright et al., 2011)

inferred from genetic interaction with FLYBASE:Stat92E; FB:FBgn0016917

(Wang et al., 2014, Wright et al., 2011)

inferred from genetic interaction with FLYBASE:Socs36E; FB:FBgn0041184

(Wright et al., 2011)

inferred from genetic interaction with FLYBASE:dome; FB:FBgn0043903

(Wright et al., 2011)

inferred from genetic interaction with FLYBASE:Ptp61F; FB:FBgn0267487

(Wright et al., 2011)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

involved_in antimicrobial humoral response

traceable author statement

(Evans et al., 2003)

involved_in embryonic development via the syncytial blastoderm

inferred from electronic annotation with InterPro:IPR031901

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

Cellular Component (1 term)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

located_in extracellular space

inferred from direct assay

(Zhou et al., 2013, Wright et al., 2011)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

located_in extracellular space

inferred from sequence model

(Oldefest et al., 2013)

Gene Group (FlyBase)

UNPAIRED FAMILY

Pathway (FlyBase)

JAK-STAT Signaling Pathway Core Components

Protein Family (UniProt)

-

Protein Signatures (InterPro)

Unpaired protein

Summaries

Gene Snapshot

unpaired 3 (upd3) encodes a "cytokine" (secreted protein) of the Unpaired family that can bind and activate the JAK-STAT receptor encoded by dome. It is induced in hemocytes or in the intestine upon damage to regulate the repair response in these tissues through JAK-STAT activation. [Date last reviewed: 2019-03-21]

Gene Group (FlyBase)

UNPAIRED FAMILY -: The Unpaired (UPD) family encodes the only known cytokines capable of activating the JAK/STAT pathway in D.mel, by binding the receptor dome. This pathway is involved in cell proliferation, embryonic development and stem cell maintenance. (Adapted from FBrf0232479, FBrf0213113 and FBrf0219535).

Pathway (FlyBase)

JAK-STAT Signaling Pathway Core Components -: The JAK-STAT signaling pathway is initiated by the binding of an extracellular ligand to a cell surface receptor leading to receptor dimerization and the intracellular activation of a Janus kinase (JAK) family member. JAK phosphorylates cytoplasmic STAT family members which dimerize, translocate into the nucleus and regulate target gene expression. In Drosophila, the core pathway is limited to three ligands (the Unpaired family of cytokines), a single receptor (dome), JAK kinase (hop) and STAT (Stat92E). (Adapted from FBrf0225259).

Summary (Interactive Fly)

interleukin-like ligands of Domeless - activators of JAK/STAT signaling pathway - mutation results in the stripe-specific loss of expression of , , and

Interactive Fly

Gene Model and Products

Number of Transcripts

1

Number of Unique Polypeptides

1

Please see the JBrowse view of Dmel\upd3 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

Gene model reviewed during 5.53

Sequence Ontology: Class of Gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

FBtr0113465

2221

401

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

FBpp0112376

45.6

401

11.46

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Unpaired protein

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

Q59E38

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\upd3 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

upd3_1

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 13 -- 16

(Brown et al., 2006)

embryonic stage 14 -- 16

(Hombria et al., 2005)

third instar larval stage

medullary zone of lymph gland primary lobe

(Makki et al., 2010)

posterior signalling center of lymph gland primary lobe

(Makki et al., 2010)

cortical zone of lymph gland primary lobe | restricted

(Makki et al., 2010)

RT-PCR

Stage

Tissue/Position (including subcellular localization)

Reference

third instar larval stage

embryonic/larval lymph gland

(Makki et al., 2010)

Additional Descriptive Data

upd3 transcript is expressed in the medullary zone and posterior signalling centre of the lymph gland primary lobe, and in scattered cells in the cortical zone.

(Makki et al., 2010)

upd3 is expressed in the gonad at stage 13 when the gonad has just coalesced and later refines anteriorly in the gonad.

(Brown et al., 2006)

upd3 is also expressed in adult hemocytes in response to bacterial challenge.

(Hombria et al., 2005)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in extracellular space

inferred from direct assay

(Zhou et al., 2013, Wright et al., 2011)

Expression Deduced from Reporters

Reporter: P{upd3-GAL4.A}

Stage

Tissue/Position (including subcellular localization)

Reference

(Reitman et al., 2015)

third instar larval stage

medullary zone of lymph gland primary lobe

(Jung et al., 2005)

posterior signalling center of lymph gland primary lobe

(Jung et al., 2005)

wandering third instar larval stage

wing hinge primordium | restricted

(Wang et al., 2014)

dorsal mesothoracic pleura primordium | restricted

(Wang et al., 2014)

wing pouch | restricted

(Wang et al., 2014)

embryonic/larval optic stalk

(Wang et al., 2014)

eye disc posterior compartment | restricted

(Wang et al., 2014)

(Jung et al., 2005, Agaisse et al., 2003)

adult proventriculus

(Buchon et al., 2009)

(Buchon et al., 2009)

(Osman et al., 2012)

adult midgut region R3a

(Guo et al., 2013)

adult midgut region R3b

(Guo et al., 2013)

adult midgut region R4

(Guo et al., 2013)

adult midgut region R5

(Guo et al., 2013)

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\upd3 in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\upd3

View exonic expression by tissue for Dmel\upd3

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0053542

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0053542

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG15062-RA;CG5963-RA

Flygut - An atlas of the Drosophila adult midgut

FBgn0053542

Images

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 13 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 25 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of upd3

Transgenic constructs containing regulatory region of upd3

Aberrations (Deficiencies and Duplications) ( 5 )

Inferred from experimentation ( 5 )

Gene partially disrupted in

(Gilbert et al., 2005)

Gene disrupted in

(Wang et al., 2014)

(Hombria et al., 2005)

(Wang et al., 2014)

(Wang et al., 2014)

(Hombria et al., 2005)

Inferred from location ( 0 )

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

upd3^GD6811

viable, with Scer\GAL4^Mef2.PR

upd3^GD6811

viable, with Scer\GAL4^pnr-MD237

upd3^GD6811

Sterility

Allele

upd3^d232a

upd3^d232a

male sterile | progressive

upd3^d232a

Other Phenotypes

Allele

abnormal immune response

upd3^d232a

abnormal immune response | adult stage

upd3^Δ

abnormal immune response | adult stage, with Scer\GAL4^crq.Unk

upd3^KK110348

abnormal immune response | adult stage, with Scer\GAL4^Myo31DF.PU

upd3^dsRNA.UAS

abnormal immune response | adult stage, with Scer\GAL4^Su(H).GBE

upd3^dsRNA.UAS

abnormal size, with Scer\GAL4^en-e16E

upd3^KK110348

abnormal size, with Scer\GAL4^GMR.PU

upd3^d04951

abnormal size | third instar larval stage, with Scer\GAL4^path-c135

upd3^UAS.cUa

decreased occurrence of cell division

upd3^Δ9

decreased occurrence of cell division | adult stage

upd3^Δ

decreased occurrence of cell division | adult stage | conditional

upd3^Δ

increased occurrence of cell division | adult stage, with Scer\GAL4^NP0001

upd3^UAS.cMa

increased occurrence of cell division | adult stage, with Scer\GAL4^NP5130

upd3^Δ9

long lived | conditional

upd3^Δ

short lived, with Scer\GAL4^Hml.Δ

upd3^UAS.cUa

short lived | nutrition conditional, with Scer\GAL4^c564

upd3^UAS.cUa

visible (with Ab(1)os^s)

upd3^d232a

visible (with Df(1)os1A2)

visible (with Df(1)os¹)

visible (with Df(1)os^o)

visible (with upd3^d232a)

upd3^x21b

visible (with upd3^x21b)

upd3^d232a

Phenotype manifest in

Allele

adult gut, with Scer\GAL4^NP0001

upd3^UAS.cMa

adult midgut, with Scer\GAL4^NP5130

upd3^UASp.cZa

adult midgut | conditional

upd3^Δ

border follicle cell

upd3^d232a

border follicle cell, with Scer\GAL4^slbo.2.6

upd3^d04951

border follicle cell, with Scer\GAL4^upd1-E132

upd3^d04951

embryonic abdominal segment 1

upd3^UE69

embryonic abdominal segment 2

upd3^UE69

embryonic abdominal segment 3

upd3^UE69

embryonic abdominal segment 4

upd3^UE69

embryonic abdominal segment 5

upd3^UE69

embryonic abdominal segment 6

upd3^UE69

embryonic abdominal segment 7

upd3^UE69

embryonic abdominal segment 8

upd3^UE69

embryonic head segment

upd3^UE69

embryonic mesothoracic segment

upd3^UE69

embryonic metathoracic segment

upd3^UE69

embryonic prothoracic segment

upd3^UE69

eye, with Scer\GAL4^GMR.PU

upd3^d04951

eye (with Ab(1)os^s)

upd3^d232a

eye (with Df(1)os1A2)

eye (with Df(1)os¹)

eye (with Df(1)os^o)

upd3^d232a

eye (with upd3^d232a)

upd3^x21b

eye (with upd3^x21b)

upd3^d232a

eye disc | third instar larval stage, with Scer\GAL4^path-c135

upd3^UAS.cUa

upd3^d232a

intestinal stem cell of posterior adult midgut epithelium

upd3^Δ9

intestinal stem cell of posterior adult midgut epithelium, with Scer\GAL4^Myo31DF.PU

upd3^dsRNA.UAS

intestinal stem cell of posterior adult midgut epithelium, with Scer\GAL4^Su(H).GBE

upd3^dsRNA.UAS

intestinal stem cell of posterior adult midgut epithelium, with Scer\GAL4^upd3.PZ

upd3^UASp.cZa

midgut, with Scer\GAL4^NP5130, Scer\GAL80^ts.αTub84B

upd3^UAS.cMa

upd3^x21b

posterior spiracle primordium

upd3^UE69

wing (with Df(1)os1A2)

wing (with Df(1)os¹)

wing (with Df(1)os^o)

upd3^x21b

wing (with upd3^d232a)

upd3^x21b

wing (with upd3^x21b)

upd3^d232a

wing | posterior, with Scer\GAL4^en-e16E

upd3^KK110348

Orthologs

Downloads

Download All DIOPT Orthologs

Download All OrthoDB Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (0)

No records found.

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (0)

No records found.

Rattus norvegicus (Norway rat) (0)

No records found.

Xenopus tropicalis (Western clawed frog) (0)

No records found.

Danio rerio (Zebrafish) (0)

No records found.

Caenorhabditis elegans (Nematode, roundworm) (0)

No records found.

Arabidopsis thaliana (thale-cress) (0)

No records found.

Saccharomyces cerevisiae (Brewer's yeast) (0)

No records found.

Schizosaccharomyces pombe (Fission yeast) (0)

No records found.

Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG09190B4X )

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila suzukii

Spotted wing Drosophila

Dsuz\DS10_00007985

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Drosophila persimilis

Drosophila willistoni

Drosophila virilis

Drosophila mojavensis

Drosophila grimshawi

Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( None identified )

No non-Drosophilid orthologies identified

Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( None identified )

No non-Dipteran orthologies identified

Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( None identified )

No non-Insect Arthropod orthologies identified

Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( None identified )

No non-Arthropod Metazoa orthologies identified

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (2)

Gene Symbol

Score

Source

Alignment

1 of 10

1 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Allele

Disease

Evidence

References

model of cancer

CEA with Ras85D^V12.UAS

(Wu et al., 2010)

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 3 )

Allele

Disease

Interaction

References

ameliorates hematologic cancer

modeled by hop^{UAS.ORF.Tag:HA}

(Terriente-Félix et al., 2017)

DOES NOT ameliorate cancer

modeled by Hipk^UAS.Tag:HA

(Blaquiere et al., 2018)

ameliorates cancer

modeled by Dl^UAS.cDa, Not3^KK102144

(Vicente et al., 2018)

modeled by Dl^UAS.cDa, twin^KK108897

(Vicente et al., 2018)

ameliorates hematologic cancer

modeled by hop^Tum

(Bailetti et al., 2019)

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

RNA-RNA

Physical Interaction

Assay

References

quantitative reverse transcription pcr

(Kim et al., 2017)

protein-protein

Physical Interaction

Assay

References

anti tag coimmunoprecipitation, anti tag western blot

(Fisher et al., 2016)

Summary of Genetic Interactions

esyN Network Diagram

esyN Network Key:

Suppression

Enhancement

View in Interactions Browser

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

suppressible

(Nie et al., 2015)

suppressible

(Buchon et al., 2010)

suppressible

(Nie et al., 2015)

suppressible

(Buchon et al., 2010)

enhanceable

(Wang et al., 2014)

enhanceable

(Wang et al., 2014)

enhanceable

(Osman et al., 2012)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

suppressible

(Worley et al., 2018)

suppressible

(Worley et al., 2018)

suppressible

(Vicente et al., 2018)

suppressible

(Vicente et al., 2018)

suppressible

(Vicente et al., 2018)

suppressible

(Tian et al., 2017)

suppressible

(Mundorf et al., 2019)

suppressible

(Jacques et al., 2009)

enhanceable

(Blaquiere et al., 2018)

suppressible

(Djiane et al., 2013)

suppressible

(Obata et al., 2018)

suppressible

(Zhang et al., 2019)

suppressible

(Zhai et al., 2015)

suppressible

(Wang et al., 2016)

suppressible

(Wang et al., 2015)

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0053542

MIST (protein-protein) - An integrated Molecular Interaction Database

upd3

Pathways

Signaling Pathways (FlyBase)

JAK-STAT Signaling Pathway Core Components -: The JAK-STAT signaling pathway is initiated by the binding of an extracellular ligand to a cell surface receptor leading to receptor dimerization and the intracellular activation of a Janus kinase (JAK) family member. JAK phosphorylates cytoplasmic STAT family members which dimerize, translocate into the nucleus and regulate target gene expression. In Drosophila, the core pathway is limited to three ligands (the Unpaired family of cytokines), a single receptor (dome), JAK kinase (hop) and STAT (Stat92E). (Adapted from FBrf0225259).

Metabolic Pathways

External Data

Linkouts

KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.

Hippo signaling pathway - fly

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Genomic Location and Detailed Mapping Data

Chromosome (arm)

X

Recombination map

1-60

Cytogenetic map

Sequence location

X:18,277,233..18,284,596 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

17A4-17A4

Limits computationally determined from genome sequence between P{EP}ari-1^EP317 and P{EP}EP1378

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

1-60

(FlyBase, 2016)

1-59.1

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (36)

55728

19355

w¹¹¹⁸ P{XP}upd3^d11639

55729

w^* upd2^Δ upd3^Δ

28575

y¹ v¹; P{TRiP.HM05061}attP2

78

Df(1)os^o, upd1^os-o upd3^os-o

79

Ab(1)os^s, upd1^os-s upd3^os-s

91978

y¹ sc^* v¹ sev²¹; P{SAM.GS03202}attP2

105718

Df(1)os^o, upd1^os-o upd3^os-o

105719

Ab(1)os^s, upd1^os-s upd3^os-s

v106869

P{KK110348}VIE-260B

v27134

w¹¹¹⁸; P{GD6811}v27134

v27136

w¹¹¹⁸; P{GD6811}v27136

More stocks available...

Genomic Clones (16)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (3)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

FI03911

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0053542

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0053542

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

3346149

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for database merge of

Source for merge of: upd3 CG5963 CG15062

(FlyBase Genome Annotators, 2005)

Additional comments

Annotations CG5963 and CG15062 merged as CG33542 (which corresponds to upd3) in release 4.1 of the genome annotation.

(FlyBase Genome Annotators, 2005)

"upd" and "os" can be genetically separated. This raises the possibility that "os" function may reside with an "upd-like" gene ("upd2" or "upd3").

(Wang, 2005)

Other Comments

upd2 and upd3 exhibit an additive effect in inducing intestinal stem cell proliferation in response to gut infection.

(Osman et al., 2012)

Gene expression is increased in response to the presence of two copies of Scer\GAL4^hs.PB.

(Liu and Lehmann, 2008)

Origin and Etymology

Discoverer

Etymology

Identification

External Crossreferences and Linkouts ( 31 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

3346149

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Q59E38

Other crossreferences

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0053542

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0053542

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

upd3_1

Flygut - An atlas of the Drosophila adult midgut

FBgn0053542

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

3346149

InterPro - A database of protein families, domains and functional sites

Unpaired protein

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG33542

modMine - A data warehouse for the modENCODE project

FBgn0053542

SignaLink - A signaling pathway resource with multi-layered regulatory networks.

Q59E38

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0053542

DRSC - Results frm RNAi screens

FBgn0053542

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0053542

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG15062-RA;CG5963-RA

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0053542

FlyMine - An integrated database for Drosophila genomics

FBgn0053542

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.

Hippo signaling pathway - fly

MIST (protein-protein) - An integrated Molecular Interaction Database

upd3

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Synonyms and Secondary IDs (33)

Reported As

Symbol Synonym

CG15062

(Brown et al., 2006, Agaisse and Perrimon, 2004, Agaisse et al., 2003, Castelli-Gair Hombria and Brown, 2002, Hou et al., 2002)

CG15062/CG5963

(Bina and Zeidler, 2006)

CG33542

(Wright et al., 2011, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Perkins et al., 2009)

CG5963

(Otsuna and Ito, 2006, Wawersik et al., 2005, Agaisse and Perrimon, 2004, Agaisse et al., 2003, Castelli-Gair Hombria and Brown, 2002, Hou et al., 2002)

UPD3

(Ferrandon, 2013, Arbouzova and Zeidler, 2006, Leclerc and Reichhart, 2004)

Upd

(Casares and McGregor, 2021, Kim et al., 2019, Svendsen et al., 2019, Mbodj et al., 2016)

Upd-3

(Clavería and Torres, 2016, Markstein et al., 2014, Wang et al., 2014)

Upd-like

(Wells et al., 2013, Agaisse et al., 2003)

Upd3

(Schneider and Imler, 2021, Colombani and Andersen, 2020, Hao et al., 2020, Horne-Badovinac, 2020, Kwon et al., 2020, Tafesh-Edwards and Eleftherianos, 2020, Zhou et al., 2020, Ho et al., 2019, Powers and Srivastava, 2019, Sanuki et al., 2019, Takeda et al., 2018, Yu et al., 2018, Daisley et al., 2017, Gervais and Bardin, 2017, Houtz et al., 2017, Kim et al., 2017, Liu and Jin, 2017, Liu and Jin, 2017, Liu et al., 2017, Mussabekova et al., 2017, Zhou et al., 2017, Alaraby et al., 2016, Fisher et al., 2016, Jiang et al., 2016, Vanha-Aho et al., 2016, Bae et al., 2015, Buchon and Osman, 2015, Gold and Brückner, 2015, Nie et al., 2015, Pasco et al., 2015, Vlisidou and Wood, 2015, Wang et al., 2015, Zhou et al., 2015, Bausek and Zeidler, 2014, Chakrabarti et al., 2014, Guo et al., 2014, Huang et al., 2014, Kux and Pitsouli, 2014, Bausek, 2013, Buchon et al., 2013, Fossett, 2013, Kuraishi et al., 2013, Mbodj et al., 2013, Morin-Poulard et al., 2013, Oldefest et al., 2013, Zeidler and Bausek, 2013, Zoranovic et al., 2013, Amoyel and Bach, 2012, Gurudatta et al., 2012, Igboin et al., 2012, Kounatidis and Ligoxygakis, 2012, Liu et al., 2012, Apidianakis and Rahme, 2011, Biteau et al., 2011, Crozatier and Vincent, 2011, Jiang et al., 2011, Stec and Zeidler, 2011, Wright et al., 2011, Zhao et al., 2011, Ren et al., 2010, Jiang et al., 2009, Sotillos et al., 2008, Pei and Harrison, 2007)

cg15062

(Brown et al., 2003)

cg5963

(Brown et al., 2003)

od

odsy

os

(Ekas et al., 2010, Wang and Huang, 2009, Wang and Harrison, 2007, Mukherjee et al., 2006, Wang et al., 2006, Chao et al., 2004, Sorrentino et al., 2004, Tsai and Sun, 2004, Agaisse et al., 2003, Betz et al., 2001, Tsai and Sun, 2001, Harrison et al., 1998, Verderosa and Muller, 1954)

sy

unpaired 3

(Wang et al., 2016)

upd

(Martinez and Cavalli, 2010)

upd 3

(Gupta and Vale, 2017)

upd-3

(Kolahgar et al., 2015, Cronin et al., 2009, Malagoli et al., 2008)

upd3

(Destalminil-Letourneau et al., 2021, Gogia et al., 2021, Ahmed et al., 2020, Bajpai et al., 2020, Chen et al., 2020, Cho et al., 2020, Harris et al., 2020, Huang et al., 2020, Kierdorf et al., 2020, La Marca and Richardson, 2020, Ma et al., 2020, Makhnovskii et al., 2020, Maselko et al., 2020, Nagai et al., 2020, Ramond et al., 2020, Strilbytska et al., 2020, Strilbytska et al., 2020, Vizcaya-Molina et al., 2020, von Frieling et al., 2020, Xu et al., 2020, Ahlers et al., 2019, Asri et al., 2019, Bailetti et al., 2019, Banerjee et al., 2019, Barik and Mishra, 2019, Gultekin and Steller, 2019, Herrera and Bach, 2019, Hill et al., 2019, Ho et al., 2019, Houtz et al., 2019, Hudry et al., 2019, Ji et al., 2019, Khezri and Rusten, 2019, Mundorf et al., 2019, Nie et al., 2019, Reedy et al., 2019, Sanchez Bosch et al., 2019, Si et al., 2019, Singh et al., 2019, Troha and Buchon, 2019, Xu et al., 2019, Zhang et al., 2019, Ahmed-de-Prado et al., 2018, Akagi et al., 2018, Bazzi et al., 2018, Doupé et al., 2018, Gáliková and Klepsatel, 2018, Hori et al., 2018, La Fortezza et al., 2018, Li et al., 2018, Obata et al., 2018, Prange et al., 2018, Tokusumi et al., 2018, Ueda et al., 2018, Vicente et al., 2018, Beshel et al., 2017, Katheder et al., 2017, Kenmoku et al., 2017, Lee et al., 2017, Péan et al., 2017, Takemura and Nakato, 2017, Terriente-Félix et al., 2017, Tian et al., 2017, Transgenic RNAi Project members, 2017-, Wang et al., 2017, Zhang et al., 2017, Atkins et al., 2016, Fink et al., 2016, Guillou et al., 2016, Guo et al., 2016, Hoi et al., 2016, Shen et al., 2016, Shih et al., 2016, Tian et al., 2016, Wang et al., 2016, Doggett et al., 2015, Katsuyama et al., 2015, Külshammer et al., 2015, Santabárbara-Ruiz et al., 2015, Shapiro-Kulnane et al., 2015, Woodcock et al., 2015, Xia et al., 2015, Zang et al., 2015, Zhai et al., 2015, Chambers et al., 2014, Evans et al., 2014, Fernando et al., 2014, Huang et al., 2014, Kux and Pitsouli, 2014, Li et al., 2014, Wang et al., 2014, Yu et al., 2014, Aleksic et al., 2013, Djiane et al., 2013, Garcia et al., 2013, Guo et al., 2013, Kemp et al., 2013, Kingsolver et al., 2013, Morin-Poulard et al., 2013, Sinha et al., 2013, Zhou et al., 2013, Zoranovic et al., 2013, Amoyel and Bach, 2012, Chakrabarti et al., 2012, Cordero et al., 2012, Kelsey et al., 2012, Osman et al., 2012, Osman et al., 2012, Poernbacher et al., 2012, Rajan and Perrimon, 2012, Feng et al., 2011, Jiang et al., 2011, Karpac et al., 2011, Kuraishi et al., 2011, Marcu et al., 2011, Opota et al., 2011, Paredes et al., 2011, Sinenko et al., 2011, Wright et al., 2011, Beebe et al., 2010, Buchon et al., 2010, Makki et al., 2010, Shaw et al., 2010, Sotillos et al., 2010, Wu et al., 2010, Buchon et al., 2009, Buchon et al., 2009, Classen et al., 2009, Jacques et al., 2009, Liu and Lehmann, 2008, López-Onieva et al., 2008, Pastor-Pareja et al., 2008, Rivas et al., 2008, Sexton and Harrison, 2008, Wang and Harrison, 2008, Avila and Erickson, 2007, Sexton and Harrison, 2007, Wang and Harrison, 2007, Brun et al., 2006, Hombria et al., 2005, Wawersik et al., 2005)

Name Synonyms

Unpaired 3

(Lee et al., 2014, Crozatier and Vincent, 2011, Buchon et al., 2009)

Unpaired 3β

(Buchon et al., 2009)

Unpaired-3

(Di Gregorio et al., 2016, Castillo et al., 2015)

Unpaired3

(Tokusumi et al., 2018, Yu et al., 2018, Sinha et al., 2013, Sotillos et al., 2008)

Upd3

(Bonfini et al., 2016)

outstretched

(Ekas et al., 2010)

outstretched-smalleye

small-eye

unpaired

unpaired 3

(Shen et al., 2016, Piccirillo et al., 2014, Hill-Burns and Clark, 2009, Kula-Eversole and Hatini, 2007, Agaisse and Perrimon, 2004)

unpaired-3

(Igboin et al., 2012, Malagoli et al., 2008)

unpaired-3.3

(Muzzopappa et al., 2017)

unpaired-like protein 3

(Oldefest et al., 2013)

unpaired3

(Marcu et al., 2011)

upd homolog

(Feng et al., 2012)

Secondary FlyBase IDs

FBgn0030909
FBgn0030910
FBgn0069074

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

References (327)