os, Upd, upd-3, Upd-like, outstretched
interleukin-like ligands of Domeless - activators of JAK/STAT signaling pathway - mutation results in the stripe-specific loss of expression of , , and
Please see the JBrowse view of Dmel\upd3 for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.53
There is only one protein coding transcript and one polypeptide associated with this gene
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\upd3 using the Feature Mapper tool.
upd3 transcript is expressed in the medullary zone and posterior signalling centre of the lymph gland primary lobe, and in scattered cells in the cortical zone.
upd3 is expressed in the gonad at stage 13 when the gonad has just coalesced and later refines anteriorly in the gonad.
upd3 is also expressed in adult hemocytes in response to bacterial challenge.
GBrowse - Visual display of RNA-Seq signals
View Dmel\upd3 in GBrowse 21-60
1-59.1
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for merge of: upd3 CG5963 CG15062
Annotations CG5963 and CG15062 merged as CG33542 (which corresponds to upd3) in release 4.1 of the genome annotation.
"upd" and "os" can be genetically separated. This raises the possibility that "os" function may reside with an "upd-like" gene ("upd2" or "upd3").
Gene expression is increased in response to the presence of two copies of Scer\GAL4hs.PB.