Gene model reviewed during 5.53
Gene model reviewed during 6.23
There is only one protein coding transcript and one polypeptide associated with this gene
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\upd2 using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\upd2 in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for identity of: CG5988 upd2
"upd" and "os" can be genetically separated. This raises the possibility that "os" function may reside with an "upd-like" gene ("upd2" or "upd3").
upd2 is a secreted factor produced by the fat body in response to dietary fat and sugars. upd2 activates JAK/STAT signaling in a population of GABAergic neurons, relieving their inhibitory effect on the insulin-producing cells and in turn resulting in the secretion of insulin-like peptides into the hemolymph to promote systemic growth and fat storage.
Gene expression is increased in response to the presence of two copies of Scer\GAL4hs.PB.