FlyBase Allele Report: Scer\GAL4[Hand.Δ]

General Information

Symbol

Scer\GAL4^Hand.Δ

Species

S. cerevisiae

Name

FlyBase ID

FBal0366188

Feature type

allele

Associated gene

Scer\GAL4

Associated Insertion(s)

Carried in Construct

P{Hand-GAL4.Δ}

Also Known As

handΔ-gal4

Transgenic product class

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

Mutagen

in vitro construct

(Destalminil-Letourneau et al., 2021)

Progenitor genotype

Carried in construct

P{Hand-GAL4.Δ}

Cytology

Description

Hand regulatory sequences (the third intron with the visceral mesoderm enhancer deleted) drives expression of GAL4.

(Destalminil-Letourneau et al., 2021)

Allele components

Component

Use(s)

Encoded product / tool

GAL4

binary expression system - driver

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal cell number | larval stage, with ds^JF02842

(Destalminil-Letourneau et al., 2021)

abnormal immune response | larval stage, with 5-HT1B^HMS00300

(Liu et al., 2025)

abnormal immune response | larval stage, with 5-HT1B^JF01851

(Liu et al., 2025)

abnormal immune response | larval stage, with 5-HT1B^RNAi.UAS.cUa

(Liu et al., 2025)

abnormal immune response | larval stage, with hop^HMS00761

(Liu et al., 2025)

abnormal immune response | larval stage, with hop^Tum.UAS

(Liu et al., 2025)

decreased cell number | larval stage, with bnl^UAS.cSa

(Destalminil-Letourneau et al., 2021)

increased cell number | larval stage, with Actβ^GD3157

(Destalminil-Letourneau et al., 2021)

increased cell number | larval stage, with bnl^GD3070

(Destalminil-Letourneau et al., 2021)

increased cell number | larval stage, with bnl^HMS01046

(Destalminil-Letourneau et al., 2021)

increased cell number | larval stage, with boss^GD292

(Destalminil-Letourneau et al., 2021)

increased cell number | larval stage, with daw^KK110248

(Destalminil-Letourneau et al., 2021)

increased cell number | larval stage, with egr^KK103432

(Destalminil-Letourneau et al., 2021)

increased cell number | larval stage, with hh^GD193

(Destalminil-Letourneau et al., 2021)

increased cell number | larval stage, with Ilp6^GD3987

(Destalminil-Letourneau et al., 2021)

increased cell number | larval stage, with Pvf3^KK112796

(Destalminil-Letourneau et al., 2021)

increased cell number | larval stage, with Sar1^HMS00355

(Destalminil-Letourneau et al., 2021)

increased cell number | larval stage, with Ser^GD14453

(Destalminil-Letourneau et al., 2021)

increased cell number | larval stage, with spz4^GD1087

(Destalminil-Letourneau et al., 2021)

increased cell number | larval stage, with tsl^GD6215

(Destalminil-Letourneau et al., 2021)

increased cell number | larval stage, with upd1^GD1158

(Destalminil-Letourneau et al., 2021)

increased cell number | larval stage, with upd1^JF03149

(Destalminil-Letourneau et al., 2021)

increased cell number | larval stage, with upd2^HMS00901

(Destalminil-Letourneau et al., 2021)

increased cell number | larval stage, with upd2^HMS00948

(Destalminil-Letourneau et al., 2021)

increased cell number | larval stage, with upd3^RNAi.UAS

(Destalminil-Letourneau et al., 2021)

increased cell number | larval stage, with Wnt6^KK107855

(Destalminil-Letourneau et al., 2021)

increased cell number | larval stage, with Wnt10^JF03423

(Destalminil-Letourneau et al., 2021)

Phenotype Manifest In

embryonic/larval crystal cell | decreased number | larval stage, with bnl^UAS.cSa

(Destalminil-Letourneau et al., 2021)

embryonic/larval crystal cell | increased number | larval stage, with Actβ^GD3157

(Destalminil-Letourneau et al., 2021)

embryonic/larval crystal cell | increased number | larval stage, with bnl^GD3070

(Destalminil-Letourneau et al., 2021)

embryonic/larval crystal cell | increased number | larval stage, with bnl^HMS01046

(Destalminil-Letourneau et al., 2021)

embryonic/larval crystal cell | increased number | larval stage, with boss^GD292

(Destalminil-Letourneau et al., 2021)

embryonic/larval crystal cell | increased number | larval stage, with daw^KK110248

(Destalminil-Letourneau et al., 2021)

embryonic/larval crystal cell | increased number | larval stage, with ds^JF02842

(Destalminil-Letourneau et al., 2021)

embryonic/larval crystal cell | increased number | larval stage, with egr^KK103432

(Destalminil-Letourneau et al., 2021)

embryonic/larval crystal cell | increased number | larval stage, with hh^GD193

(Destalminil-Letourneau et al., 2021)

embryonic/larval crystal cell | increased number | larval stage, with Pvf3^KK112796

(Destalminil-Letourneau et al., 2021)

embryonic/larval crystal cell | increased number | larval stage, with Sar1^HMS00355

(Destalminil-Letourneau et al., 2021)

embryonic/larval crystal cell | increased number | larval stage, with Ser^GD14453

(Destalminil-Letourneau et al., 2021)

embryonic/larval crystal cell | increased number | larval stage, with tsl^GD6215

(Destalminil-Letourneau et al., 2021)

embryonic/larval crystal cell | increased number | larval stage, with upd1^GD1158

(Destalminil-Letourneau et al., 2021)

embryonic/larval crystal cell | increased number | larval stage, with upd1^JF03149

(Destalminil-Letourneau et al., 2021)

embryonic/larval crystal cell | increased number | larval stage, with upd2^HMS00901

(Destalminil-Letourneau et al., 2021)

embryonic/larval crystal cell | increased number | larval stage, with upd2^HMS00948

(Destalminil-Letourneau et al., 2021)

embryonic/larval crystal cell | increased number | larval stage, with upd3^RNAi.UAS

(Destalminil-Letourneau et al., 2021)

embryonic/larval crystal cell | increased number | larval stage, with Wnt6^KK107855

(Destalminil-Letourneau et al., 2021)

embryonic/larval crystal cell | increased number | larval stage, with Wnt10^JF03423

(Destalminil-Letourneau et al., 2021)

embryonic/larval lymph gland | larval stage, with 5-HT1B^HMS00300

(Liu et al., 2025)

embryonic/larval lymph gland | larval stage, with 5-HT1B^JF01851

(Liu et al., 2025)

embryonic/larval lymph gland | larval stage, with 5-HT1B^RNAi.UAS.cUa

(Liu et al., 2025)

embryonic/larval lymph gland | larval stage, with hop^HMS00761

(Liu et al., 2025)

embryonic/larval lymph gland | larval stage, with Timp^UAS.cPa

(Liu et al., 2025)

embryonic/larval plasmatocyte | larval stage, with bnl^GD3070

(Destalminil-Letourneau et al., 2021)

extracellular matrix | larval stage, with hop^HMS00761

(Liu et al., 2025)

extracellular matrix | larval stage | conditional, with 5-HT1B^RNAi.UAS.cUa

(Liu et al., 2025)

lamellocyte | decreased number, with 5-HT1B^RNAi.UAS.cUa

(Liu et al., 2025)

lymph gland posterior signaling center cell | decreased number | larval stage, with ds^JF02842

(Destalminil-Letourneau et al., 2021)

lymph gland posterior signaling center cell | increased number | larval stage, with Ilp6^GD3987

(Destalminil-Letourneau et al., 2021)

lymph gland posterior signaling center cell | increased number | larval stage, with Sar1^HMS00355

(Destalminil-Letourneau et al., 2021)

lymph gland posterior signaling center cell | increased number | larval stage, with spz4^GD1087

(Destalminil-Letourneau et al., 2021)

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

5-HT1B^RNAi.UAS.cUa, Scer\GAL4^Hand.Δ has abnormal immune response | larval stage phenotype, suppressible | partially by hop^Tum.UAS, Scer\GAL4^Hand.Δ

(Liu et al., 2025)

Sar1^HMS00355, Scer\GAL4^Hand.Δ has increased cell number | larval stage phenotype, suppressible by bnl^UAS.HA-GFP-3, Scer\GAL4^Hand.Δ

(Destalminil-Letourneau et al., 2021)

Suppressor of

Statement

Reference

hop^Tum.UAS, Scer\GAL4^Hand.Δ is a suppressor | partially of abnormal immune response | larval stage phenotype of 5-HT1B^RNAi.UAS.cUa, Scer\GAL4^Hand.Δ

(Liu et al., 2025)

bnl^UAS.HA-GFP-3, Scer\GAL4^Hand.Δ is a suppressor of increased cell number | larval stage phenotype of Sar1^HMS00355, Scer\GAL4^Hand.Δ

(Destalminil-Letourneau et al., 2021)

Phenotype Manifest In

NOT Enhanced by

Statement

Reference

5-HT1B^RNAi.UAS.cUa, Scer\GAL4^Hand.Δ has extracellular matrix | larval stage | conditional phenotype, non-enhanceable by Timp^UAS.cPa, Scer\GAL4^Hand.Δ

(Liu et al., 2025)

Suppressed by

Statement

Reference

5-HT1B^RNAi.UAS.cUa, Scer\GAL4^Hand.Δ has embryonic/larval lymph gland | larval stage phenotype, suppressible | partially by hop^Tum.UAS, Scer\GAL4^Hand.Δ

(Liu et al., 2025)

5-HT1B^RNAi.UAS.cUa, Scer\GAL4^Hand.Δ has extracellular matrix | larval stage | conditional phenotype, suppressible | partially by hop^Tum.UAS, Scer\GAL4^Hand.Δ

(Liu et al., 2025)

5-HT1B^RNAi.UAS.cUa, Scer\GAL4^Hand.Δ has embryonic/larval lymph gland | larval stage phenotype, suppressible | partially by Timp^UAS.cPa, Scer\GAL4^Hand.Δ

(Liu et al., 2025)

Sar1^HMS00355, Scer\GAL4^Hand.Δ has embryonic/larval crystal cell | increased number | larval stage phenotype, suppressible by bnl^UAS.HA-GFP-3, Scer\GAL4^Hand.Δ

(Destalminil-Letourneau et al., 2021)

NOT suppressed by

Statement

Reference

5-HT1B^RNAi.UAS.cUa, Scer\GAL4^Hand.Δ has extracellular matrix | larval stage | conditional phenotype, non-suppressible by Timp^UAS.cPa, Scer\GAL4^Hand.Δ

(Liu et al., 2025)

NOT Enhancer of

Statement

Reference

Timp^UAS.cPa, Scer\GAL4^Hand.Δ is a non-enhancer of extracellular matrix | larval stage | conditional phenotype of 5-HT1B^RNAi.UAS.cUa, Scer\GAL4^Hand.Δ

(Liu et al., 2025)

Suppressor of

Statement

Reference

hop^Tum.UAS, Scer\GAL4^Hand.Δ is a suppressor | partially of embryonic/larval lymph gland | larval stage phenotype of 5-HT1B^RNAi.UAS.cUa, Scer\GAL4^Hand.Δ

(Liu et al., 2025)

hop^Tum.UAS, Scer\GAL4^Hand.Δ is a suppressor | partially of extracellular matrix | larval stage | conditional phenotype of 5-HT1B^RNAi.UAS.cUa, Scer\GAL4^Hand.Δ

(Liu et al., 2025)

Timp^UAS.cPa, Scer\GAL4^Hand.Δ is a suppressor | partially of embryonic/larval lymph gland | larval stage phenotype of 5-HT1B^RNAi.UAS.cUa, Scer\GAL4^Hand.Δ

(Liu et al., 2025)

bnl^UAS.HA-GFP-3, Scer\GAL4^Hand.Δ is a suppressor of embryonic/larval crystal cell | increased number | larval stage phenotype of Sar1^HMS00355, Scer\GAL4^Hand.Δ

(Destalminil-Letourneau et al., 2021)

NOT Suppressor of

Statement

Reference

Timp^UAS.cPa, Scer\GAL4^Hand.Δ is a non-suppressor of extracellular matrix | larval stage | conditional phenotype of 5-HT1B^RNAi.UAS.cUa, Scer\GAL4^Hand.Δ

(Liu et al., 2025)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescues

bnl^UAS.cSa/Scer\GAL4^Hand.Δ rescues bnl^GD3070

(Destalminil-Letourneau et al., 2021)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Scer\GAL4^Hand.Δ

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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