FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\ActβGD3157
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General Information
Symbol
Dmel\ActβGD3157
Species
D. melanogaster
Name
FlyBase ID
FBal0209045
Feature type
allele
Associated gene
Dmel\Actβ
Associated Insertion(s)
Carried in Construct
P{GD3157}
Key Links
Genomic Maps

Transgenic product class
RNAi_reagent
(Dickson et al., 2007.7.18)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Dickson et al., 2007.7.18)
Mutagen
in vitro construct
(Dickson et al., 2007.7.18)
Progenitor genotype
Carried in construct
P{GD3157}
Cytology
Description

UASt regulatory sequences drive expression of an inverted repeat.

(Dickson et al., 2007.7.18)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
dsRNA-GD3157
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of ActβGD3157 in the eye under the control of Scer\GAL4GMR.long significantly expands the dendritic field size of Dm8 neurons as compared to wild type. As in wild type the Dm8 neurons are routed to the M6 layer. Expression of ActβGD3157 in photoreceptors also causes abnormal dendritic patterning in about 20% of the Tm20 neurons: that is, Tm20 dendrites fail to remain in their cognate column and, instead, extend into neighboring columns. Expression of ActβGD3157 in rhabdomere R8 under the control of Scer\GAL4sens.F2 causes similar, but somewhat weaker, dendritic patterning defects in Tm20 neurons.

      (Ting et al., 2014)

      Adults expressing ActβGD3157 under the control of Scer\GAL4elav.PLu (in the presence of Dcr-2Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.

      (Neely et al., 2010)
      External Data
      Linkouts
      Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT Enhancer of
      Phenotype Manifest In
      NOT Enhancer of
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression of ActβGD3157 does not significantly enhance the Tm20 dendritic patterning defects seen when rhabdomere R8 terminals are stalled in medulla layer M1 through expression of gogoFL.Scer\UAS.T:Hsap\MYC under the control of Scer\GAL4GMR.long.

      (Ting et al., 2014)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 1 )
      Linkouts
      Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      ActβGD3157
      activin-βGD3157
      Name Synonyms
      Secondary FlyBase IDs
        References (11)