FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
Allele: Dmel\upd1GD1158
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General Information
Symbol
Dmel\upd1GD1158
Species
D. melanogaster
Name
FlyBase ID
FBal0210263
Feature type
allele
Associated gene
Dmel\upd1
Associated Insertion(s)
Carried in Construct
P{GD1158}
Also Known As
UAS-updRNAi
Key Links
Genomic Maps

Transgenic product class
RNAi_reagent
(Dickson et al., 2007.7.18)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Dickson et al., 2007.7.18)
Mutagen
in vitro construct
(Dickson et al., 2007.7.18)
Progenitor genotype
Carried in construct
P{GD1158}
Cytology
Description

UASt regulatory sequences drive expression of an inverted repeat.

(Dickson et al., 2007.7.18)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
dsRNA-GD1158
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Epithelium turnover in the midgut is blocked in flies expressing upd1GD1158 under the control of Scer\GAL4tub.PU and Scer\GAL4esg-NP7397 in the intestinal stem cells (ISCs) and their subsequent lineage (using the "esg[F/O]" flip-out lineage system to mark ISC progenitors and their subsequent lineage). ISC division is also strongly inhibited.

      The response of increased proliferation of intestinal stem cells which is seen in wild-type flies after oral infection with Erwinia carotovora carotovora 15 is blocked in animals expressing upd1GD1158 under the control of Scer\GAL4esg-NP5130.

      (Osman et al., 2012)

      Expression of upd1GD1158 under the control of Scer\GAL4upd1.PU results in a reduction in the number of outer border follicle cells compared to wild type and also results in defects in border follicle cell migration. Expression under the control of Scer\GAL4slbo.2.6 does not cause these phenotypes.

      (Van De Bor et al., 2011)

      Adults expressing upd1GD1158 under the control of Scer\GAL4elav.PLu (in the presence of Dcr-2Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.

      (Neely et al., 2010)

      Scer\GAL4Myo31DF-NP0001-mediated expression of upd1GD1158 results in significantly increased survival following infection with S. marcescens compared to controls.

      (Cronin et al., 2009)
      External Data
      Linkouts
      Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      NOT Suppressor of
      Statement
      Reference

      upd1GD1158/Scer\GAL4Su(H).GBE is a non-suppressor of neoplasia phenotype of Sox21a6

      (Zhai et al., 2015)
      Phenotype Manifest In
      Suppressed by
      Suppressor of
      NOT Suppressor of
      Statement
      Reference

      upd1GD1158/Scer\GAL4Su(H).GBE is a non-suppressor of adult anterior midgut epithelium phenotype of Sox21a6

      (Zhai et al., 2015)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression of upd1GD1158 in enteroblasts under the control of Scer\GAL4Su(H).GBE does not reduce tumor formation in the anterior midgut of Sox21a6 mutant flies.

      (Zhai et al., 2015)

      The melanotic tumour phenotype see in animals carrying gcmDN.Scer\UAS.T:Rep-en, Scer\GAL4srp.D.cCa and Scer\GAL80ts.αTub84B which have been raised at 18[o]C and then shifted to 29[o]C during the first larval instar stage is completely suppressed if they are also co-expressing upd1GD1158.

      (Jacques et al., 2009)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 1 )
      Linkouts
      Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      osGD1158
      upd1GD1158
      updi-2
      (Cao et al., 2022)
      Name Synonyms
      Secondary FlyBase IDs
        References (23)