FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term intestinal stem cell ID (Ontology) FBbt:00007039 (Fly Anatomy)
Definition Wedge shaped diploid cell found in scattered clusters in the midgut epithelium. The broad end of the wedge lies on the basement membrane and contains the nucleus. The tapering apex of the cell extends up towards the lumen.[ FlyBase:FBrf0007735 FlyBase:FBrf0191251 FlyBase:FBrf0227510 ]
Also Known As"ISC"
CommentCan be identified by expression of Delta (and escargot) (Zeng and Hou, 2015).
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Direct annotations: records annotated with this exact term (child terms are NOT included)
Data ClassFieldDirect annotations
Alleles (FBal)PHENOTYPE_MANIFEST_IN
Insertions (FBti)EXPRESSION_STAGE_TISSUE_POSITION
Insertions (FBti)PHENOTYPE_MANIFEST_IN
Constructs (FBtp)PHENOTYPE_MANIFEST_IN
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 Full annotation statements 
Relevant FlyBase reports
 Alleles Genes  Insertions Constructs
 intestinal stem cell (all annotations which use CV term, excluding "NOT" statements)
     intestinal stem cell | adult stage
      --       --
     intestinal stem cell | adult stage | cell non-autonomous
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     intestinal stem cell | adult stage | cell non-autonomous | increased number
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     intestinal stem cell | adult stage | chemical conditional
      --       --       --
     intestinal stem cell | adult stage | decreased number
      --       --       --
     intestinal stem cell | adult stage | decreased number | somatic clone
      --       --       --
     intestinal stem cell | adult stage | increased number
      --       --
     intestinal stem cell | adult stage | nutrition conditional
      --       --       --
     intestinal stem cell | adult stage | somatic clone
      --       --       --
     intestinal stem cell | chemical conditional
      --       --       --
     intestinal stem cell | decreased number
      --       --       --
     intestinal stem cell | decreased number | conditional
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     intestinal stem cell | decreased number | somatic clone
      --       --       --
     intestinal stem cell | increased number
      --       --
     intestinal stem cell | increased number | heat sensitive
      --       --       --
     intestinal stem cell | increased number | somatic clone
      --       --       --       --
     intestinal stem cell | late third instar larval stage | somatic clone
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     intestinal stem cell | male | progressive
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     intestinal stem cell | P-stage | increased number
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     intestinal stem cell | prepupal stage | somatic clone
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     intestinal stem cell | progressive
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     intestinal stem cell | pupal stage | somatic clone
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     intestinal stem cell | RU486 conditional
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     intestinal stem cell | somatic clone
      --       --
     intestinal stem cell | somatic clone | increased number
      --       --       --
     intestinal stem cell | somatic clone | increased number | heat sensitive
      --       --       --       --
     intestinal stem cell | temperature conditional
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Spanning Tree (Parents/Children)
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adult midgut
 |__adult midgut epithelium__
somatic precursor cell       |
 |__somatic stem cell________|
stem cell                    |
 |__somatic stem cell________|
midgut epithelium            |
 |__adult midgut epithelium__|
                             intestinal stem cell  659 rec.
                              |__intestinal stem cell of posterior adult midgut epithelium 217 rec.
                                  |__intestinal stem cell of the adult midgut-hindgut boundary 14 rec.
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Is a somatic stem cell
Part of adult midgut epithelium
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