FlyBase Allele Report: Dmel\Ser[GD14453]

General Information

Symbol

Dmel\Ser^GD14453

Species

D. melanogaster

Name

FlyBase ID

FBal0208512

Feature type

allele

Associated gene

Dmel\Ser

Associated Insertion(s)

Carried in Construct

P{GD14453}

Also Known As

UAS-Ser^RNAi

Key Links

Genomic Maps

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Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

in vitro construct - RNAi

(Dickson et al., 2007.7.18)

in vitro construct - regulatory fusion

(Dickson et al., 2007.7.18)

Mutations Mapped to the Genome

Type

Location

Additional Notes

References

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Progenitor genotype

Carried in construct

P{GD14453}

Cytology

Nature of the lesion

Statement

Reference

UASt regulatory sequences drive expression of an inverted repeat.

(Dickson et al., 2007.7.18)

Allele components

Product class / Tool use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

Ser

Associated Sequence Features

dsRNA-GD14453

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal body color, with Scer\GAL4^pnr-MD237

(Mummery-Widmer et al., 2009)

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

(Neely et al., 2010)

viable, with Scer\GAL4^Mef2.PR

(Schnorrer et al., 2010)

viable, with Scer\GAL4^pnr-MD237

(Mummery-Widmer et al., 2009)

viable, with Scer\GAL4^tin.CΔ4

(Neely et al., 2010)

visible, with Scer\GAL4^pnr-MD237

(Mummery-Widmer et al., 2009)

Phenotype Manifest In

mesothoracic tergum, with Scer\GAL4^pnr-MD237

(Mummery-Widmer et al., 2009)

trichogen cell, with Scer\GAL4^pnr-MD237

(Mummery-Widmer et al., 2009)

Detailed Description

Statement

Reference

Expression of Ser^GD14453 under the control of either Scer\GAL4^Mef2.PR or Scer\GAL4^elav-C155 has no significant effect on the number of abdominal lateral adult muscle precursor cells in mid-third instar larvae, as compared to controls.

(Aradhya et al., 2015)

Expression of Ser^GD14453 under the control of Scer\GAL4^bab1-Gal4 (limited to the adult stages using Scer\GAL80^ts.αTub84B) has no effect on the number of germline stem cell and cap cells in one week old female flies compared to controls.

(Yang et al., 2013)

Adults expressing Ser^GD14453 under the control of Scer\GAL4^elav.PLu (in the presence of Dcr-2^Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.

(Neely et al., 2010)

Expression under the control of Scer\GAL4^pnr-MD237 results in a colour difference between the central Scer\GAL4^pnr-MD237 expression domain of the notum and the surrounding lateral region in 30-40% or 40-50% of the Scer\GAL4^pnr-MD237 expression domain, depending on the insertion line used.

Expression under the control of Scer\GAL4^pnr-MD237 results in bristle morphology defects on the notum in 0% or 60-70% of the Scer\GAL4^pnr-MD237 expression domain, depending on the insertion line used.

(Mummery-Widmer et al., 2009)

External Data

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development

14453

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhancer of

Statement

Reference

Ser^GD14453, Scer\GAL4^bab1-Gal4 is a non-enhancer of decreased cell number phenotype of Dl^GD2642, Scer\GAL4^bab1-Gal4, Scer\GAL80^ts.αTub84B

(Yang et al., 2013)

Phenotype Manifest In

NOT Enhancer of

Statement

Reference

Ser^GD14453, Scer\GAL4^bab1-Gal4 is a non-enhancer of germline stem cell phenotype of Dl^GD2642, Scer\GAL4^bab1-Gal4, Scer\GAL80^ts.αTub84B

(Yang et al., 2013)

Ser^GD14453, Scer\GAL4^bab1-Gal4 is a non-enhancer of germarium cap cell phenotype of Dl^GD2642, Scer\GAL4^bab1-Gal4, Scer\GAL80^ts.αTub84B

(Yang et al., 2013)

Additional Comments

Genetic Interactions

Statement

Reference

Expression of Ser^GD14453 does not enhance the germline stem cell and cap cell loss seen when Dl^GD2642 is expressed under the control of Scer\GAL4^bab1-Gal4 (limited to the adult stages using Scer\GAL80^ts.αTub84B).

(Yang et al., 2013)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

VDRC

v27174