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General Information
Symbol
Dmel\upd1JF03149
Species
D. melanogaster
Name
FlyBase ID
FBal0239648
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
UAS-upd1RNAi
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UAS regulatory sequences drive expression of an inverted repeat.

Allele components
Product class / Tool use(s)
Encoded product / tool
Associated Sequence Features
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 1 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Expression of upd1JF03149 under the control of Scer\GAL4Cg.PA has no effect on either body weight or attraction to food cues in adult flies, whereas expression driven in the neural tissue by Scer\GAL4elav.PU heightens the attraction to food in fed flies so that it is comparable to the response observed in their starved counterparts as well as starved control flies (and higher than in fed controls). Scer\GAL4elav.PU>upd1JF03149 flies also consume more food and weigh more than controls (but their relative fat storage levels are not significantly increased).

Limiting the Scer\GAL4elav.PU-driven expression of upd1JF03149 only to the developmental stage (by using tub-Gal80[ts] in conjunction with temperature manipulations to control the temporal expression profile) does not lead to any significant changes in response to food odor, food intake or average body weight in adult flies, whereas adult-onset upd1 knock-down results in a marked increase in all three, as compared to controls.

Scer\GAL4en-e16E-mediated expression results in a modest reduction in size of the posterior compartment of the adult wing.

Expression of upd1JF03149 under the control of Scer\GAL4ppl.PP does not result in a reduction in body size.

Expression of upd1JF03149 under the control of Scer\GAL4Cg.PA has no effect on triacylglycerol levels in adults.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

The increased attraction to food cues, increased food consumption and higher body weight of adult flies expressing upd1JF03149 under the control of Scer\GAL4elav.PU can be rescued by co-expression of upd2Scer\UAS.T:Avic\GFP-EGFP.

Xenogenetic Interactions
Statement
Reference

The increased attraction to food cues, increased food consumption and higher body weight of adult flies expressing upd1JF03149 under the control of Scer\GAL4elav.PU can be rescued by co-expression of Hsap\LEPScer\UAS.cRa.

Complementation and Rescue Data
Comments

The increased attraction to food cues, increased food consumption and higher body weight of adult flies expressing upd1JF03149 under the control of Scer\GAL4elav.PU can be rescued by expression of upd1Scer\UAS.cUa.

Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Symbol Synonym
Upd1RNAi
osJF03149
upd1JF03149
Name Synonyms
Secondary FlyBase IDs
    References (10)