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General Information
Symbol
Dmel\NUAS.icd
Species
D. melanogaster
Name
FlyBase ID
FBal0120742
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
UAS-Nicd, UAS-Nicd
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UAS sequences drive expression of the intracellular domain of N.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 1 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 1 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Expression of NScer\UAS.icd under the control of Scer\GAL4Scer\FRT.Act5C in third instar wing disc clones leads to wing disc hyperplasia, significantly higher levels of extracellular acidification, a decrease in the glycolytic reserve, lower oxygen consumption rate, and lower production of mitochondrial ATP in the wing disc, as compared to controls.

Expression of NScer\UAS.icd under the control of Scer\GAL4ptc.PU leads to wing disc hyperplasia in third instar larvae.

Expression of NScer\UAS.icd in randomly generated clones throughout the wing disc causes hyperplasia.

Scer\GAL4ptc-559.1-mediated expression of NScer\UAS.icd causes overgrowth of the wing disc, primarily along one axis.

Expression of NScer\UAS.icd under the control of Scer\GAL4sca-C253 leads to bristle loss on the notum, following suppression of sensory organ precursor cells.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressed by
Statement
Reference
NOT suppressed by
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

Co-expression of ImpL3KK102330 or Hex-AKK100831 partially rescues the wing disc hyperplasia seen in larvae expressing NScer\UAS.icd under the control of Scer\GAL4ptc.PU.

Coexpression of btl::EgfrScer\UAS.T:λ\cI-DD with NScer\UAS.icd, under the control of Scer\GAL4sca-C253, suppresses the bristle-loss phenotype on the notum seen when NScer\UAS.icd alone is expressed.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
NScer\UAS.icd
NUAS.icd
Name Synonyms
Secondary FlyBase IDs
    References (10)