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General Information
Symbol
Dmel\sdKK108877
Species
D. melanogaster
Name
FlyBase ID
FBal0235890
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
UAS-Sd RNAi, sd RNAi
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UASt regulatory sequences drive expression of an inverted repeat.

Allele components
Product class / Tool use(s)
Encoded product / tool
Associated Sequence Features
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

The expression of sdKK108877 under the control of Scer\GAL4ey-OK107, Scer\GAL4c739 or Scer\GAL4sd-SG29.1 (always in combination with Dicer-2 expression, for efficient RNAi) leads to significant increases in the mushroom body and the Kenyon cell cluster sizes, as compared to controls; the Scer\GAL4sd-SG29.1-driven expression also leads to a significant increase in the proportion of mitotic neuroblasts and ganglion mother cells, despite of no change in neuroblast number, in Kenyon cell clusters and leads to a significant increase in Kenyon cell size, as compared to controls. Clonal expression of sdKK108877 under the control of Scer\GAL4insc-Mz1407 (in combination with Dicer-2 expression, for efficient RNAi) leads to a significant increase in Kenyon cell size and to a significant increase in clone cell number, despite of no changes in apoptosis or in neuroblast number and size, within Kenyon cell clusters, as compared to controls.

Expression of sdKK108877 under the control of Scer\GAL4C587 has no apparent germarium phenotype.

Expression of sdKK108877 under the control of Scer\GAL4Bx-MS1096 results in male flies with almost complete wing loss.

Expression of sdKK108877 under the control of Scer\GAL4Bx-MS1096 results in female flies with almost complete wing loss.

Scer\GAL4tj-NP1624-mediated expression results in an incomplete epithelial monolayer of egg chambers at stage 2.

Expression of sdKK108877 (co-expressed with Dcr-2Scer\UAS.cDa) under the control of Scer\GAL4repo.PU reduces glial cell numbers in the third instar larval eye disc.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

Clones that are both wtsx1 homozygous and express sdKK108877 under the control of Scer\GAL4Tub.PU are lethal in the wing.

The marked delay in pupariation characteristic for larvae expressing Syx7KK101990 under the control of Scer\GAL4rn.PU can be partially suppressed by co-expression of sdKK108877.

sdKK108877 completely suppresses the eye overgrowth phenotype seen in flies co-expressing RtGEFHMS00741 and ykiS168A.Scer\UAS.T:Avic\GFP-YFP under the control of Scer\GAL4GMR.PF.

The female sterility due to tumorous germaria induced by Scer\GAL4C587-driven expression of ykidsRNA.shRNA.Scer\UAS.P\T is rescued by co-expression of sdKK108877 - the double knock-down females are fertile and without significant germaria defects.

The rather moderate tumorous germarium phenotype characteristic for adult female flies expressing cidsRNA.shRNA.Scer\UAS.P\T under the control of Scer\GAL4C587 is significantly improved by co-expression of sdKK108877.

Expression of sdKK108877 suppresses the increase in glial cell number seen in larval eye discs expressing ykiS168A.Scer\UAS.T:SV5\V5 under the control of Scer\GAL4repo.PU.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
sdKK108877
Name Synonyms
Secondary FlyBase IDs
    References (17)