FlyBase Allele Report: Dmel\ci[RNAi.UASp.cLa]

General Information

Symbol

Dmel\ci^{RNAi.UASp.cLa}

Species

D. melanogaster

Name

FlyBase ID

FBal0324765

Feature type

allele

Associated gene

Dmel\ci

Associated Insertion(s)

Carried in Construct

P{UASp-ci.RNAi.L}

Key Links

Transgenic product class

RNAi_reagent

(Li et al., 2015)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Li et al., 2015)

Mutagen

in vitro construct

(Li et al., 2015)

Progenitor genotype

Carried in construct

P{UASp-ci.RNAi.L}

Cytology

Description

UASp regulatory sequences drive expression of an shRNA that targets ci.

(Li et al., 2015)

Allele components

Component

Use(s)

Regulatory region(s)

UASp

binary expression system - regulatory region

Encoded product / tool

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

neoplasia | adult stage | female, with Scer\GAL4^C587

(Li et al., 2015)

Phenotype Manifest In

germarium, with Scer\GAL4^C587

(Li et al., 2015)

Detailed Description

Statement

Reference

Expression of ci^{dsRNA.shRNA.Scer\UAS.P\T} under the control of Scer\GAL4^{nos.UTR.T:Hsim\VP16} has no detectable germarium phenotype, however expression under the Scer\GAL4^C587 driver is moderately tumorigenic.

(Li et al., 2015)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Scer\GAL4^C587, ci^{RNAi.UASp.cLa} has neoplasia | adult stage | female phenotype, enhanceable by Scer\GAL4^C587/hpo^UAS.cWa

(Li et al., 2015)

Scer\GAL4^C587, ci^{RNAi.UASp.cLa} has neoplasia | adult stage | female phenotype, enhanceable by Scer\GAL4^C587/wts^UAS.cYa

(Li et al., 2015)

Suppressed by

Statement

Reference

Scer\GAL4^C587, ci^{RNAi.UASp.cLa} has neoplasia | female | adult stage phenotype, suppressible | partially by Scer\GAL4^C587/hpo^RNAi.UAS.cUa

(Li et al., 2015)

Scer\GAL4^C587, ci^{RNAi.UASp.cLa} has neoplasia | female | adult stage phenotype, suppressible | partially by wts^RNAi.UAS.cUa/Scer\GAL4^C587

(Li et al., 2015)

Scer\GAL4^C587, ci^{RNAi.UASp.cLa} has neoplasia | female | adult stage phenotype, suppressible | partially by yki^UAS.cHa/Scer\GAL4^C587

(Li et al., 2015)

Scer\GAL4^C587, ci^{RNAi.UASp.cLa} has neoplasia | female | adult stage phenotype, suppressible | partially by Scer\GAL4^C587/sd^KK108877

(Li et al., 2015)

Scer\GAL4^C587, ci^{RNAi.UASp.cLa} has neoplasia | female | adult stage phenotype, suppressible | partially by Scer\GAL4^C587/Tgi^HMS00981

(Li et al., 2015)

Scer\GAL4^C587, ci^{RNAi.UASp.cLa} has neoplasia | female | adult stage phenotype, suppressible | partially by Scer\GAL4^C587/vg^RNAi.UAS.cUa

(Li et al., 2015)

Scer\GAL4^C587, ci^{RNAi.UASp.cLa}, hpo^UAS.cWa has neoplasia | female | adult stage phenotype, suppressible | partially by wts^RNAi.UAS.cUa/Scer\GAL4^C587

(Li et al., 2015)

Scer\GAL4^C587, ci^{RNAi.UASp.cLa}, hpo^UAS.cWa has neoplasia | female | adult stage phenotype, suppressible | partially by yki^UAS.cHa/Scer\GAL4^C587

(Li et al., 2015)

Phenotype Manifest In

Enhanced by

Statement

Reference

Scer\GAL4^C587, ci^{RNAi.UASp.cLa} has germarium phenotype, enhanceable by Scer\GAL4^C587/hpo^UAS.cWa

(Li et al., 2015)

Scer\GAL4^C587, ci^{RNAi.UASp.cLa} has germarium phenotype, enhanceable by Scer\GAL4^C587/wts^UAS.cYa

(Li et al., 2015)

Suppressed by

Statement

Reference

Scer\GAL4^C587, ci^{RNAi.UASp.cLa} has germarium phenotype, suppressible | partially by yki^UAS.cHa/Scer\GAL4^C587

(Li et al., 2015)

Scer\GAL4^C587, ci^{RNAi.UASp.cLa} has germarium phenotype, suppressible | partially by Scer\GAL4^C587/sd^KK108877

(Li et al., 2015)

Scer\GAL4^C587, ci^{RNAi.UASp.cLa} has germarium phenotype, suppressible | partially by Scer\GAL4^C587/Tgi^HMS00981

(Li et al., 2015)

Scer\GAL4^C587, ci^{RNAi.UASp.cLa} has germarium phenotype, suppressible | partially by Scer\GAL4^C587/vg^RNAi.UAS.cUa

(Li et al., 2015)

Scer\GAL4^C587, ci^{RNAi.UASp.cLa}, hpo^UAS.cWa has germarium phenotype, suppressible | partially by wts^RNAi.UAS.cUa/Scer\GAL4^C587

(Li et al., 2015)

Scer\GAL4^C587, ci^{RNAi.UASp.cLa}, hpo^UAS.cWa has germarium phenotype, suppressible | partially by yki^UAS.cHa/Scer\GAL4^C587

(Li et al., 2015)

Scer\GAL4^C587, ci^{RNAi.UASp.cLa} has germarium phenotype, suppressible | partially by Scer\GAL4^C587/hpo^RNAi.UAS.cUa

(Li et al., 2015)

Scer\GAL4^C587, ci^{RNAi.UASp.cLa} has germarium phenotype, suppressible | partially by wts^RNAi.UAS.cUa/Scer\GAL4^C587

(Li et al., 2015)

Additional Comments

Genetic Interactions

Statement

Reference

The rather moderate tumorous germarium phenotype characteristic for adult female flies expressing ci^{dsRNA.shRNA.Scer\UAS.P\T} under the control of Scer\GAL4^C587 is strongly aggravated by co-expression of either hpo^Scer\UAS.cWa or wts^Scer\UAS.cYa and significantly improved by co-expression of any of the following: hpo^VDRC.cUa, sd^KK108877, Tgi^HMS00981, vg^{dsRNA.Scer\UAS.cUa}, wts^VDRC.cUa or yki^Scer\UAS.cHa. Co-expression of either wts^VDRC.cUa or yki^Scer\UAS.cHa can also partially rescue the aggravated tumorous phenotype of flies expressing both ci^{dsRNA.shRNA.Scer\UAS.P\T} and hpo^Scer\UAS.cWa simultaneously.

(Li et al., 2015)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

ci^{RNAi.UASp.cLa}

ci^{dsRNA.shRNA.Scer\UAS.P\T}

ci^{dsRNA.shRNA.UASp}

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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