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General Information
Symbol
Dmel\hthB2
Species
D. melanogaster
Name
FlyBase ID
FBal0065836
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Nucleotide change:

G10562033A

Comment:

Nucleotide substitution of G to A at the splice acceptor site.

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Nucleotide substitution: G?A. Mutation is at the 3' splice site of intron 6.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 1 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Large hthB2 mutant clones generated in a Minute background result in ectopic ventral photoreceptor differentiation but do not cause outgrowths.

Ommatidia located in homozygous clones that are touching the dorsal rim area (DRA) of the eye lose the enlarged inner photoreceptor rhabdomeres that are typical of DRA ommatidia.

Mutant embryos show a relatively mild phenotype in the PNS, which consists mainly of dorsal localisation of LCh5 neurons in some of the abdominal segments.

Somatic clones in the head, induced during larval stages, lead to ectopic eye structures in the head. the ventral head region (gena and rostral membrane) is reduced as a consequence of the production of ectopic eyes, and the maxillary palps are frequently absent or abnormal in these clones. Occasionally incomplete ommatidia with missing photoreceptors and fewer bristles are seen, most of the times at the interface between clonal and wild-type tissue. Clones within the eye also show ommatidial polarity defects - the induction of ectopic equators is seen occurring parallel to the endogenous equatorial axis and accompanied by frequent inversion of ommatidia polarity along the anterior posterior axis. These defects are both cell- and non-cell-autonomous.

The normal pattern of the cuticle is disrupted in homozygous embryos and hthB2/Df(3R)hth embryos, with hthB2/Df(3R)hth embryos having a stronger phenotype than homozygous embryos.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Fails to complement
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (7)