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Agaisse, H., Petersen, U.M., Boutros, M., Mathey-Prevot, B., Perrimon, N. (2003). Signaling role of hemocytes in Drosophila JAK/STAT-dependent response to septic injury.  Dev. Cell 5(3): 441--450.
FlyBase ID
FBrf0162064
Publication Type
Research paper
Abstract

To characterize the features of JAK/STAT signaling in Drosophila immune response, we have identified totA as a gene that is regulated by the JAK/STAT pathway in response to septic injury. We show that septic injury triggers the hemocyte-specific expression of upd3, a gene encoding a novel Upd-like cytokine that is necessary for the JAK/STAT-dependent activation of totA in the Drosophila counterpart of the mammalian liver, the fat body. In addition, we demonstrate that totA activation also requires the NF-KB-like Relish pathway, indicating that fat body cells integrate the activity of NF-KB and JAK/STAT signaling pathways upon immune response. This study reveals that, in addition to the pattern recognition receptor-mediated NF-KB-dependent immune response, Drosophila undergoes a complex systemic response that is mediated by the production of cytokines in blood cells, a process that is similar to the acute phase response in mammals.

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Related Publication(s)
Review

A cytokine in the Drosophila stress response.
Hultmark and Ekengren, 2003, Dev. Cell 5(3): 360--361 [FBrf0162059]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Dev. Cell
    Title
    Developmental Cell
    Publication Year
    2001-
    ISBN/ISSN
    1534-5807 1878-1551
    Data From Reference
    Aberrations (2)
    Alleles (15)
    Genes (15)
    Sequence Features (1)
    Insertions (1)
    Experimental Tools (2)
    Transgenic Constructs (8)
    Transcripts (1)