FlyBase Allele Report: Dmel\hop[32]

General Information

Symbol

Dmel\hop³²

Species

D. melanogaster

Name

FlyBase ID

FBal0005543

Feature type

allele

Associated gene

Dmel\hop

Associated Insertion(s)

Carried in Construct

Also Known As

hop^M38

Key Links

Genomic Maps

JBrowse

Allele class

amorphic allele - genetic evidence

Mutagen

ethyl nitrosourea

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Perrimon and Mahowald, 1986)

Mutagen

ethyl nitrosourea

Progenitor genotype

Cytology

Description

Mutation is within the C-terminal end of the kinase domain.

(Luo et al., 1999)

Amino acid replacement: W1134term.

(Luo et al., 1999)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

X:11,361,948..11,361,948 [-]

Nucleotide change:

G11361948A

Amino acid change:

W1134term | hop-PA

Reported amino acid change:

W1134term

Comment:

G to A nucleotide change at the second or third position of the wild type Trp codon leads to a nonsense mutation (exact site of mutation unspecified). The mutation was annotated at the second base of the codon.

(Luo et al., 1999)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal cell number | oogenesis (with hop²⁵)

(McGregor et al., 2002)

abnormal immune response (with hop²⁵)

(Kemp et al., 2013, Dostert et al., 2005, Agaisse et al., 2003)

lethal | rescuable maternal effect

(Perrimon and Mahowald, 1986)

partially lethal (with hop²⁵)

(Harrison et al., 1998)

visible (with hop²⁵)

(Rawlings et al., 2004)

Phenotype Manifest In

egg chamber (with hop²⁵)

(McGregor et al., 2002)

eye

(Luo et al., 1999)

interommatidial bristle

(Luo et al., 1999)

ommatidium

(Luo et al., 1999)

stalk follicle cell (with hop²⁵)

(McGregor et al., 2002)

wing vein | ectopic (with hop²⁵)

(Rawlings et al., 2004)

Detailed Description

Statement

Reference

hop³²/hop²⁵ mutant flies die more rapidly than do wild-type controls following Drosophila C virus (DCV) infection, and contain about 10-fold more virus.

Compared with wild-type, hop³²/hop²⁵ mutant flies show decreased survival and contain significantly more virus particles when injected with Cricket Paralysis Virus (CrPV).

(Kemp et al., 2013)

hop³²/hop²⁵ flies infected with Drosophila C virus have increased levels of viral RNA and viral capsid proteins than infected wild-type flies. hop³²/hop²⁵ flies show reduced survival compared to wild-type flies when injected with a low dose (1 x 10² LD₅₀) of Drosophila C virus.

(Dostert et al., 2005)

hop²⁵/hop³² animals have an ectopic vein near the posterior crossvein of the wing.

(Rawlings et al., 2004)

There is no nuclear translocation of Stat92E protein into the nuclei of cells in the fat body in response to challenge with bacteria in hop²⁵/hop³² mutant adult flies.

(Agaisse et al., 2003)

hop²⁵/hop³² females show extensive fusion of egg chambers and stalk cells are rare or absent.

(McGregor et al., 2002)

The concentration of circulating hemocytes in mutant larvae and the distribution of the different blood cell types is not different from that of controls.

(Remillieux-Leschelle et al., 2002)

hop²⁵/hop³² females can have eyes that are smaller in the dorso-ventral axis with significantly fewer ommatidia compared to wild-type. Ommatidia are arranged irregularly and duplicated bristles are seen. hop²⁵/hop³² females with an eyeless phenotype with a concomitant duplication of the antenna can also be seen.

(Luo et al., 1999)

50% viable in transheterozygous combination with hop²⁵.

(Harrison et al., 1998)

Paternal rescue of the maternal effect. Germline clone analysis demonstrates that embryos have one abdominal segment missing and A4 appears wider than wild type, and partial or complete fusion of T1 and T2.

(Perrimon and Mahowald, 1986)

larval/pupal lethal hop³²/hop²⁵ 100% viable

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

hop³²/hop²⁵ has partially lethal phenotype, enhanceable by upd1^YM55

(Harrison et al., 1998)

Other

Statement

Reference

Scer\GAL4^en-e16E, Socs44A^UAS.cRa, hop³²/hop²⁵ has lethal phenotype

(Rawlings et al., 2004)

Phenotype Manifest In

Suppressed by

Statement

Reference

hop³²/hop²⁵ has wing vein | ectopic phenotype, suppressible | partially by +/Df(2R)CA53

(Rawlings et al., 2004)

hop³²/hop²⁵ has wing vein | ectopic phenotype, suppressible | partially by Df(2R)NCX10/+

(Rawlings et al., 2004)

NOT suppressed by

Statement

Reference

hop³²/hop²⁵ has wing vein | ectopic phenotype, non-suppressible by Df(2R)Drl^rv18/+

(Rawlings et al., 2004)

Additional Comments

Genetic Interactions

Statement

Reference

The penetrance of the ectopic wing vein phenotype seen in hop²⁵/hop³² animals (98%) is decreased by Df(2R)CA53/+ (46%) or Df(2R)NCX10/+ (58%), but is not significantly decreased by Df(2R)Drl^rv18/+ (87%).

(Rawlings et al., 2004)

Viability of hop²⁵/hop³² flies is reduced if the flies also carry os^upd-4.

(Harrison et al., 1998)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Voelker.

Comments

Fully complement hop²⁵.

(Perrimon and Mahowald, 1986)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

hop³²

hop^M38

(Lamiable et al., 2016, Kemp et al., 2013, Dostert et al., 2005, Agaisse and Perrimon, 2004, Rawlings et al., 2004, Agaisse et al., 2003, Boutros et al., 2002, McGregor et al., 2002, Remillieux-Leschelle et al., 2002, Lagueux et al., 2000, Luo et al., 1999, Harrison et al., 1998)

l(1)M38

l(1)hop^M38

(Perrimon and Mahowald, 1986)

Name Synonyms

Secondary FlyBase IDs

References (13)

Report Sections

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