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Citation
Luo, H., Asha, H., Kockel, L., Parke, T., Mlodzik, M., Dearolf, C.R. (1999). The Drosophila JAK kinase hopscotch is required for multiple developmental processes in the eye.  Dev. Biol. 213(2): 432--441.
FlyBase ID
FBrf0111419
Publication Type
Research paper
Abstract

Jak kinases are critical signaling components in hematopoiesis. While a large number of studies have been conducted on the roles of Jak kinases in the hematopoietic cells, much less is known about the requirements for these tyrosine kinases in other tissues. We have used loss of function mutations in the Drosophila Jak kinase Hopscotch (Hop) to determine the role of Hop in eye development. We find that Hop is required for cell proliferation/survival in the eye imaginal disc, for the differentiation of photoreceptor cells, and for the establishment of the equator and of ommatidial polarity. These results indicate that hop activity is required for multiple developmental processes in the eye, both cell-autonomously and nonautonomously.

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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Dev. Biol.
    Title
    Developmental Biology
    Publication Year
    1959-
    ISBN/ISSN
    0012-1606
    Data From Reference
    Aberrations (1)
    Alleles (19)
    Genes (4)
    Transgenic Constructs (1)