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General Information
Symbol
Dmel\hop3
Species
D. melanogaster
Name
FlyBase ID
FBal0005514
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
hopGA32
Key Links
Mutagen
Nature of the Allele
Mutagen
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Comment:

Approximate endpoints of a 4bp deletion reported to be at residue 1121 at the C-terminal end of the kinase domain.

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

4bp deletion at the C terminal end of the kinase domain (at position 1121).

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

hop3mutants show increased mortality as a result of WNV-Kun infection when compared to controls.

Stalks form in early hop3/hop25 egg chambers and the oocyte moves to the posterior of the egg chamber as in wild type. However, the stalk cells fail to intercalate and the stalk consists of two rows of cells linked by adherens junctions. At later stages, the stalks collapse and fusions between egg chambers are seen.

hop25/hop3 mutant females have reduced fertility and fused egg chamber phenotype.

hop25/hop3 ovaries often have compound egg chambers. The chambers contain multiple germline cysts each with its own oocyte and the chambers contain a multiple of 15 ring canals per chamber, indicating that these compound chambers are due to fusion or improper incapsulation of germline cysts rather than extra rounds of germline proliferation. hop25/hop3 egg chambers have extra polar follicle cells.

hop25/hop3 females show a mild reduction in eye size and show roughness in the equatorial region, within which ommatidial fusion and duplicated bristles can be seen. In hop25/hop3 females a loss of photoreceptor cells is seen, misrotations and loss of ommatidial chirality is seen.

100% viable in transheterozygous combination with hop25.

Paternal rescue of the maternal effect. Germline clone analysis demonstrates that embryos have one abdominal segment missing and A4 appears wider than wild type, and partial or complete fusion of T1 and T2.

larval/pupal lethal hop3/hop25: percent viable: 16%

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement
Reference
Other
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

Viability of hop3/hop25 flies is reduced if the flies also carry osupd-4.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer

Lefevre.

Comments
Comments
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (4)
References (10)