FlyBase Allele Report: Dmel\hop[3]

General Information

Symbol

Dmel\hop³

Species

D. melanogaster

Name

FlyBase ID

FBal0005514

Feature type

allele

Associated gene

Dmel\hop

Associated Insertion(s)

Carried in Construct

Also Known As

hop^GA32

Key Links

Genomic Maps

JBrowse

Allele class

amorphic allele - genetic evidence

Mutagen

X ray

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Perrimon and Mahowald, 1986)

Mutagen

X ray

Progenitor genotype

Cytology

Description

4bp deletion at the C terminal end of the kinase domain (at position 1121).

(Luo et al., 1999)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

X:11,361,985..11,361,988 [-]

Comment:

Approximate endpoints of a 4bp deletion reported to be at residue 1121 at the C-terminal end of the kinase domain.

(Luo et al., 1999)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of hematologic cancer

CEA with hop^Tum

(Hanratty and Dearolf, 1993)

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal immune response

(Ahlers et al., 2019)

abnormal immune response | adult stage (with hop²⁵)

(Shen et al., 2022)

abnormal planar polarity

(Luo et al., 1999)

female semi-fertile (with hop²⁵)

(Baksa et al., 2002)

increased cell number | oogenesis (with hop²⁵)

(McGregor et al., 2002)

increased mortality (with hop²⁵)

(Shen et al., 2022)

increased mortality | conditional

(Ahlers et al., 2019)

lethal | rescuable maternal effect

(Perrimon and Mahowald, 1986)

viable (with hop²⁵)

(Harrison et al., 1998)

visible

(Luo et al., 1999)

Phenotype Manifest In

egg chamber (with hop²⁵)

(Baksa et al., 2002, McGregor et al., 2002)

eye

(Luo et al., 1999)

interommatidial bristle

(Luo et al., 1999)

ommatidium

(Luo et al., 1999)

polar follicle cell | increased number (with hop²⁵)

(McGregor et al., 2002)

stalk follicle cell (with hop²⁵)

(Assa-Kunik et al., 2007)

Detailed Description

Statement

Reference

hop³mutants show increased mortality as a result of WNV-Kun infection when compared to controls.

(Ahlers et al., 2019)

Stalks form in early hop³/hop²⁵ egg chambers and the oocyte moves to the posterior of the egg chamber as in wild type. However, the stalk cells fail to intercalate and the stalk consists of two rows of cells linked by adherens junctions. At later stages, the stalks collapse and fusions between egg chambers are seen.

(Assa-Kunik et al., 2007)

hop²⁵/hop³ mutant females have reduced fertility and fused egg chamber phenotype.

(Baksa et al., 2002)

hop²⁵/hop³ ovaries often have compound egg chambers. The chambers contain multiple germline cysts each with its own oocyte and the chambers contain a multiple of 15 ring canals per chamber, indicating that these compound chambers are due to fusion or improper incapsulation of germline cysts rather than extra rounds of germline proliferation. hop²⁵/hop³ egg chambers have extra polar follicle cells.

(McGregor et al., 2002)

hop²⁵/hop³ females show a mild reduction in eye size and show roughness in the equatorial region, within which ommatidial fusion and duplicated bristles can be seen. In hop²⁵/hop³ females a loss of photoreceptor cells is seen, misrotations and loss of ommatidial chirality is seen.

(Luo et al., 1999)

100% viable in transheterozygous combination with hop²⁵.

(Harrison et al., 1998)

Paternal rescue of the maternal effect. Germline clone analysis demonstrates that embryos have one abdominal segment missing and A4 appears wider than wild type, and partial or complete fusion of T1 and T2.

(Perrimon and Mahowald, 1986)

larval/pupal lethal hop³/hop²⁵: percent viable: 16%

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

hop³/hop²⁵ has partially lethal phenotype, enhanceable by upd1^YM55

(Harrison et al., 1998)

Other

Statement

Reference

Scer\GAL4^en-e16E, Socs44A^UAS.cRa, hop³/hop²⁵ has lethal phenotype

(Rawlings et al., 2004)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Viability of hop³/hop²⁵ flies is reduced if the flies also carry os^upd-4.

(Harrison et al., 1998)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

8495

y¹ w^* hop³/FM7c

Notes on Origin

Discoverer

Lefevre.

Comments

Complement hop²⁵ to 16%.

(Perrimon and Mahowald, 1986)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

hop³

(Shen et al., 2022, Ahlers et al., 2019)

hop^GA32

(Assa-Kunik et al., 2007, Rawlings et al., 2004, Baksa et al., 2002, McGregor et al., 2002, Luo et al., 1999, Harrison et al., 1998, Hanratty and Dearolf, 1993, Watson et al., 1991)

l(1)GA32

l(1)hop^GA32

(Perrimon and Mahowald, 1986)

Name Synonyms

Secondary FlyBase IDs

References (11)

Report Sections

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