FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\l(2)glunspecified
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General Information
Symbol
Dmel\l(2)glunspecified
Species
D. melanogaster
Name
FlyBase ID
FBal0057098
Feature type
allele
Associated gene
Dmel\l(2)gl
Associated Insertion(s)
Carried in Construct
Also Known As
unspecified
Key Links
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description

    FlyBase curator comment: this entry is used to capture phenotypic information when the particular allele (or allele combination) used by the author could not be determined but the context of the experiment suggests that the phenotype being described is some kind of loss of function.

    (FlyBase Curators, 2025-)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 1 )
        Disease
        Evidence
        References
        model of  cancer
        CEA with Ras85DV12.UAS
        (Xu et al., 2023)
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Neuroblasts in homozygous stage 15 embryos (lacking zygotic l(2)gl function) show defects in division; 57% undergo normal division, 31% undergo a symmetrical division and 12% undergo an inverted asymmetrical division.

        (Albertson and Doe, 2003)

        An ultrastructurally normal junctional complex composed of a zonula adherens and a septate junction is seen in stage 17 embryos which lack maternal and zygotic l(2)gl function.

        (Tanentzapf and Tepass, 2003)

        Embryos lacking maternal and zygotic l(2)gl function show defects in apicobasal polarity during mid-embryogenesis and disruption of adherens junctions.

        (Bilder et al., 2000)

        Larvae homozygous for a l(2)glunspecified allele that is lethal during the larval stage have underdeveloped prothoracal glands, although the corpora allata are normal. Salivary glands are 50% of normal size and polyteny is reduced. Larvae homozygous for a l(2)glunspecified allele that is lethal during the prepupal stage have underdeveloped prothoracal glands and reduced corpora allata. Salivary glands are 80% of normal size and polyteny is reduced.

        (Korochkina et al., 1975)

        The prothoracic gland cells of homozygous 140 hour old third instar larvae are smaller than normal. Glycogen deposits, secretory droplets and lysosomes, which are normally seen in wild-type cells, are absent. The volume of smooth endoplasmic reticulum (ER) is reduced to approximately 1% of that seen in wild-type, and the volume of rough ER is reduced to about 20% of the normal value. The corpus allatum appears fairly normal, although secretory deposits are not seen.

        (Aggarwal and King, 1969)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Suppressed by
        NOT suppressed by
        Enhancer of
        Statement
        Reference

        l(2)gl[+]/l(2)glunspecified is an enhancer of imaginal disc phenotype of scribunspecified

        (Bilder et al., 2000)
        Other
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        Eye-antennal disc clones that express Ras85DV12.Scer\UAS under the control of Scer\GAL4Act.PU, and in which adjacent cells are mutant for l(2)glunspecified, develop into large tumors capable of invading the ventral nerve cord.

        l(2)glunspecified mutant eye-antennal disc clones that simultaneously express Ras85DV12.Scer\UAS under the control of Scer\GAL4Act.PU grow into large metastatic tumors.

        Expression of upd1dsRNA.Scer\UAS.cUa partially suppresses the overgrowth and invasion of the nerve cord seen in l(2)glunspecified mutant eye-antennal disc clones that simultaneously express Ras85DV12.Scer\UAS under the control of Scer\GAL4Act.PU. The phenotype is further suppressed when the clones are generated in a upd2Δ3-62 mutant background.

        upd2Δ3-62 does not suppress the overgrowth and invasion of the nerve cord seen in l(2)glunspecified mutant eye-antennal disc clones that simultaneously express Ras85DV12.Scer\UAS under the control of Scer\GAL4Act.PU.

        (Wu et al., 2010)

        dlg114 ; l(2)glunspecified/+ neuroblasts show defects in division; 59% undergo normal division, 26% undergo a symmetrical division and 15% undergo an inverted asymmetrical division. dlg114 ; l(2)glunspecified/+ ; scrib1/+ neuroblasts show defects in division; 56% undergo normal division, 22% undergo a symmetrical division and 22% undergo an inverted asymmetrical division.

        (Albertson and Doe, 2003)

        When l(2)glunspecified clones are made in Nl1N-ts1/Df pupae that are moved to the restrictive temperature, loss of external cell are seen within and outside l(2)glunspecified clones.

        (Justice et al., 2003)

        Embryos lacking zygotic scrib and l(2)gl function die exhibiting phenotypes that are similar to the absence of maternal and zygotic scrib or l(2)gl function. The imaginal disc phenotype of scribunspecified hypomorphic larvae is enhanced by heterozygosity for l(2)glunspecified.

        (Bilder et al., 2000)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (3)
        Reported As
        Symbol Synonym
        l(2)glunspecified
        lgl-
        (Portela et al., 2010)
        unspecified
        (Korochkina et al., 1975, Aggarwal and King, 1969)
        Name Synonyms
        Secondary FlyBase IDs
          References (12)