FlyBase Allele Report: Dmel\upd2[Δ]

General Information

Symbol

Dmel\upd2^Δ

Species

D. melanogaster

Name

FlyBase ID

FBal0283676

Feature type

allele

Associated gene

Dmel\upd2

Associated Insertion(s)

P+PBac{XP5.WH5}upd2^Δ

Carried in Construct

Also Known As

upd2Δ

Key Links

Genomic Maps

JBrowse

Allele class

amorphic allele - molecular evidence

Mutagen

FLPase

Nature of the Allele

Allele class

amorphic allele - molecular evidence

(Osman et al., 2012)

Mutagen

FLPase

(Osman et al., 2012)

Progenitor genotype

PBac{WH}f04435

(Osman et al., 2012)

P{XP}d03621

(Osman et al., 2012)

Associated Insertion(s)

P+PBac{XP5.WH5}upd2^Δ

Cytology

Description

Scer\FLP1-mediated recombination between the two progenitor insertions has resulted in a 4.7kb deletion that removes the upd2 transcription unit.

(Osman et al., 2012)

Allele components

Component

Use(s)

Inserted element

P+PBac{XP5.WH5}

misexpression element

Regulatory region(s)

UAS

binary expression system - regulatory region

Also carries

FRT

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

X:18,238,988..18,243,732 [-]

Comment:

4.7 kb deletion generated by FLP-mediated recombination between PBac{WH}f04435 and P{XP}d03621.

(Osman et al., 2012)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal immune response | adult stage

(Osman et al., 2012)

decreased occurrence of cell division | adult stage

(Osman et al., 2012)

fertile

(Osman et al., 2012)

viable

(Osman et al., 2012)

Phenotype Manifest In

Detailed Description

Statement

Reference

Mutants do not show any major developmental defects.

The response of increased proliferation of intestinal stem cells which is seen in wild-type flies after oral infection with Erwinia carotovora carotovora 15 is reduced in mutant flies compared to wild type.

(Osman et al., 2012)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

upd2^Δ is an enhancer of abnormal immune response | adult stage phenotype of upd3^Δ

(Osman et al., 2012)

NOT Enhancer of

Statement

Reference

upd2^Δ, upd2[+], upd3^Δ, upd3[+] is a non-enhancer of visible | adult stage phenotype of CtBP^334Δ4, Scer\GAL4^rn-GAL4-5, egr^UAS.cUa, upd1^UAS.cUa

(Worley et al., 2018)

Suppressor of

Statement

Reference

upd3^Δ/upd2^Δ is a suppressor | partially of increased occurrence of cell division | recessive | adult stage phenotype of SH3PX1^d1

(Zhang et al., 2019)

upd3^Δ/upd2^Δ is a suppressor | partially of visible | adult stage phenotype of Delta^UAS.cDa, Scer\GAL4^ey.PH, twin^KK108897

(Vicente et al., 2018)

upd3^Δ/upd2^Δ is a suppressor | partially of neoplasia | adult stage phenotype of Delta^UAS.cDa, Scer\GAL4^ey.PH, twin^KK108897

(Vicente et al., 2018)

upd2[+]/upd2^Δ is a suppressor of visible | adult stage phenotype of CtBP^334Δ4, Scer\GAL4^rn-GAL4-5, egr^UAS.cUa

(Worley et al., 2018)

upd3^Δ, upd2[+], upd3[+], upd2^Δ is a suppressor of visible | adult stage phenotype of CtBP^334Δ4, Scer\GAL4^rn-GAL4-5, egr^UAS.cUa

(Worley et al., 2018)

upd2^Δ/upd2^Δ is a suppressor | partially of neoplasia phenotype of Sox21a⁶

(Zhai et al., 2015)

NOT Suppressor of

Statement

Reference

upd2^Δ, upd2[+], upd3^Δ, upd3[+] is a non-suppressor of visible | adult stage phenotype of CtBP^334Δ4, Scer\GAL4^rn-GAL4-5, egr^UAS.cUa, upd1^UAS.cUa

(Worley et al., 2018)

Other

Statement

Reference

upd2^Δ, upd3^Δ has decreased occurrence of cell division | adult stage phenotype

(Geng et al., 2025)

upd2^Δ, upd3^Δ has abnormal immune response phenotype

(Ahlers et al., 2019)

upd2^Δ, upd3^Δ has increased mortality | conditional phenotype

(Ahlers et al., 2019)

upd2^Δ, upd3^Δ has viable phenotype

(Osman et al., 2012)

upd2^Δ, upd3^Δ has fertile phenotype

(Osman et al., 2012)

Phenotype Manifest In

NOT Enhancer of

Statement

Reference

upd2^Δ, upd2[+], upd3^Δ, upd3[+] is a non-enhancer of wing | ectopic phenotype of CtBP^334Δ4, Scer\GAL4^rn-GAL4-5, egr^UAS.cUa, upd1^UAS.cUa

(Worley et al., 2018)

Suppressor of

Statement

Reference

upd3^Δ/upd2^Δ is a suppressor of central nervous system phenotype of PGRP-LE^UAS.Tag:FLAG, Scer\GAL4^repo

(Winkler et al., 2025)

upd3^Δ/upd2^Δ is a suppressor of plasmatocyte phenotype of PGRP-LE^UAS.Tag:FLAG, Scer\GAL4^repo

(Winkler et al., 2025)

upd3^Δ/upd2^Δ is a suppressor | partially of adult midgut epithelium phenotype of SH3PX1^d1

(Zhang et al., 2019)

upd3^Δ/upd2^Δ is a suppressor | partially of eye phenotype of Delta^UAS.cDa, Scer\GAL4^ey.PH, twin^KK108897

(Vicente et al., 2018)

upd2[+]/upd2^Δ is a suppressor of wing | ectopic phenotype of CtBP^334Δ4, Scer\GAL4^rn-GAL4-5, egr^UAS.cUa

(Worley et al., 2018)

upd3^Δ, upd2[+], upd3[+], upd2^Δ is a suppressor of wing | ectopic phenotype of CtBP^334Δ4, Scer\GAL4^rn-GAL4-5, egr^UAS.cUa

(Worley et al., 2018)

upd2^Δ/upd2^Δ is a suppressor | partially of adult anterior midgut epithelium phenotype of Sox21a⁶

(Zhai et al., 2015)

NOT Suppressor of

Statement

Reference

upd2^Δ, upd2[+], upd3^Δ, upd3[+] is a non-suppressor of wing | ectopic phenotype of CtBP^334Δ4, Scer\GAL4^rn-GAL4-5, egr^UAS.cUa, upd1^UAS.cUa

(Worley et al., 2018)

Other

Statement

Reference

upd2^Δ, upd3^Δ has adult midgut phenotype

(Geng et al., 2025)

Additional Comments

Genetic Interactions

Statement

Reference

upd2^Δ upd3^Δ double mutants show increased mortality as a result of WNV-Kun infection when compared to controls.

(Ahlers et al., 2019)

Expression of egr^UAS.cUa under the control of Scer\GAL4^rn-GAL4-5 (with tub-Gal80[ts] restricting expression to third instar larvae) in upd2^Δ/+ or upd2^Δ/+ upd3^Δ/+ background does not lead to ectopic wings compared to controls.

(Worley et al., 2018)

Homozygous upd2^Δ reduces tumor formation in the anterior midgut of Sox21a⁶ mutant flies.

(Zhai et al., 2015)

upd2^Δ further reduces the survival of upd3^Δ flies compared to controls after oral infection with Erwinia carotovora carotovora 15.

(Osman et al., 2012)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (3)

Bloomington

55727

w^* upd2^Δ

55729

w^* upd2^Δ upd3^Δ

604936

w^* upd2^Δ; Df(4)CORL, PBac{WHr}CORL

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

UPD2^Δ

(Kim et al., 2025)

upd2^Delta

(Houtz et al., 2019)

upd2^Δ

(Geng et al., 2025, Malita et al., 2025, Winkler et al., 2025, Wang et al., 2024, Cao et al., 2022, Kim et al., 2021, Shin et al., 2020, Ahlers et al., 2019, Bailetti et al., 2019, Zhang et al., 2019, Vicente et al., 2018, Worley et al., 2018, Kenmoku et al., 2017, Terriente-Félix et al., 2017, Zhai et al., 2015, Osman et al., 2012, Osman et al., 2012)

upd2Δ

(Cho et al., 2020, Cho et al., 2018, Patel et al., 2015)

updΔ2

(Vincow et al., 2024)

Name Synonyms

Secondary FlyBase IDs

References (24)

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