FB2026_03 , released September 17, 2026
CV Term Report
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Term cell surface receptor signaling pathway via JAK-STAT ID (Ontology) GO:0007259 (Gene Ontology)
Definition A cell surface receptor signaling pathway in which ligand binding causes the receptor to dimerize, bringing the receptor-associated JAKs into close proximity. The JAKs then phosphorylate and activate each other on tyrosine residues.This leads to the activation of associated STAT protein, causing the STATs to dissociate from the receptor, translocate to the nucleus. The pathway ends with regulation of target gene expression by STAT proteins.[ PubMed:12039028 ]
Also Known As"JAK-STAT signal transduction" ; "receptor signaling pathway via JAK-STAT"
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 cell surface receptor signaling pathway via JAK-STAT (all annotations which use CV term, excluding "NOT" statements)
     involved_in | cell surface receptor signaling pathway via JAK-STAT       --
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  cell surface receptor signaling pathway
   |__cell surface receptor signaling pathway via STAT
       |__cell surface receptor signaling pathway via JAK-STAT  46 rec.
           |__regulation of receptor signaling pathway via JAK-STAT 38 rec.
           |   |__negative regulation of receptor signaling pathway via JAK-STAT(+) 21 rec.
           |   |__positive regulation of receptor signaling pathway via JAK-STAT(+) 17 rec.
           |   |__serine phosphorylation of STAT protein(+)
           |__tyrosine phosphorylation of STAT protein
               |__regulation of tyrosine phosphorylation of STAT protein(+)
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Is a cell surface receptor signaling pathway via STAT
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  • "JAK-STAT cascade" NARROW
    "JAK-STAT signal transduction" EXACT
    "receptor signaling pathway via JAK-STAT" EXACT
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Wikipedia:JAK-STAT_signaling_pathway