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General Information
Name
JAK-STAT Signaling Pathway Core Components
Species
D. melanogaster
Symbol
JAKSTAT-C
FlyBase ID
FBgg0000881
Date last reviewed
2019-11-14
Number of members
6
Description
Description

The JAK-STAT signaling pathway is initiated by the binding of an extracellular ligand to a cell surface receptor leading to receptor dimerization and the intracellular activation of a Janus kinase (JAK) family member. JAK phosphorylates cytoplasmic STAT family members which dimerize, translocate into the nucleus and regulate target gene expression. In Drosophila, the core pathway is limited to three ligands (the Unpaired family of cytokines), a single receptor (dome), JAK kinase (hop) and STAT (Stat92E). (Adapted from FBrf0225259).

Notes and selected reviews
Biological Process Gene Ontology (GO) term(s)
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Other related group(s)
Physical Interaction Network
Members (6)
For all members:
External Data
Other resource(s)
Synonyms and Secondary IDs
Synonym(s)
JAKSTAT-C
JAK-STAT Signaling Pathway Core Components
Secondary FlyBase ID(s)
References (22)