FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Pathway: JAK-STAT SIGNALING PATHWAY
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General Information
Name
JAK-STAT SIGNALING PATHWAY
Species
D. melanogaster
Symbol
JAKSTAT
FlyBase ID
FBgg0000883
Date last reviewed
2025-12-04
Number of members
41
Description
Description
The JAK-STAT signaling pathway is initiated by the binding of an extracellular ligand to a cell surface receptor leading to receptor dimerization and the intracellular activation of a Janus kinase (JAK) family member. JAK phosphorylates cytoplasmic STAT family members which dimerize, translocate into the nucleus and regulate target gene expression. In Drosophila, the core pathway is limited to three ligands (the Unpaired family of cytokines), a single receptor (dome), JAK kinase (hop) and STAT (Stat92E). (Adapted from FBrf0225259).
Notes and selected reviews

Selected publications for background information: The Drosophila JAK-STAT pathway (FBrf0222849), Tools and methods for studying the Drosophila JAK/STAT pathway (FBrf0225259), JAK/STAT pathway dysregulation in tumors: a Drosophila perspective (FBrf0225146), JAK/STAT Pathway in Drosophila Immunity (FBrf0225141).

Biological Process Gene Ontology (GO) term(s)
cell surface receptor signaling pathway via JAK-STAT
Related Gene Groups
Component group(s)
JAK-STAT SIGNALING PATHWAY CORE COMPONENTS
NEGATIVE REGULATORS OF JAK-STAT SIGNALING PATHWAY
POSITIVE REGULATORS OF JAK-STAT SIGNALING PATHWAY
Physical Interaction Network
Members (41)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
External Data
Other resource(s)

[Summary Text - Cytokine signaling: the JAK/STAT pathway (The Interactive Fly)](http://www.sdbonline.org/sites/fly/aignfam/jakstat.htm)

[Illustration - Model of the Drosophila JAK/STAT pathway (The Interactive Fly)](http://www.sdbonline.org/sites/fly/pathway/jakstat_text.htm)

[Wikipathways - Toll, IMD, JAK/STAT Pathways for Immune Response to Pathogens (Drosophila melanogaster)](https://www.wikipathways.org/index.php/ Pathway:WP3830 )

[Wikipathways - Humoral Immune Response to Fungal and Bacterial Pathogens (Drosophila melanogaster)](https://www.wikipathways.org/index.php/ Pathway:WP3660 )

[Reactome Pathway - JAK/STAT pathway](https://reactome.org/PathwayBrowser/#/R-DME-209405&PATH=R-DME-5252538)

Synonyms and Secondary IDs
Synonym(s)
JAKSTAT
Janus kinase/signal transducers and activators of transcription pathway
JAK-STAT cascade
JAK/STAT pathway
JAK-STAT SIGNALING PATHWAY
JAK-STAT Signaling Pathway
Secondary FlyBase ID(s)
References (72)