FlyBase Gene Report: Dmel\Bub3

General Information

Symbol

Dmel\Bub3

Species

D. melanogaster

Name

Bub3

Annotation Symbol

CG7581

Feature Type

protein_coding_gene

FlyBase ID

FBgn0025457

Gene Model Status

Current

Stock Availability

8 publicly available

Gene Summary

Bub3 (Bub3) encodes a protein that functions in the spindle assembly checkpoint (SAC) pathway. This mitotic checkpoint pathway inhibits the APC/C complex and hence the transition from metaphase to anaphase, as long as there are free kinetochores that are not yet attached to the mitotic spindle in the cell. The product of Bub3 is localized at the kinetochore during mitosis with maximal levels observed at free kinetochores. Together with other SAC proteins it forms mitotic checkpoint complexes that bind and inhibit the APC/C. [Date last reviewed: 2019-03-07] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Interactive Fly

Key Links

Genomic Location

Cytogenetic map

99B7-99B7

Sequence location

3R:29,674,007..29,675,421 [-]

Recombination map

3-99

RefSeq locus

NT_033777 REGION:29674007..29675421

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

Help me choose

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (7 terms)

Molecular Function (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

enables ubiquitin binding

inferred from biological aspect of ancestor with PANTHER:PTN000103837

(assigned by GO_Central )

(Gaudet et al., 2011)

Biological Process (2 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

involved_in mitotic spindle assembly checkpoint signaling

inferred from direct assay

(Logarinho et al., 2004)

involved_in regulation of chromosome separation

inferred from mutant phenotype

(Clemente-Ruiz et al., 2016)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

involved_in mitotic spindle assembly checkpoint signaling

inferred from biological aspect of ancestor with PANTHER:PTN000103865

(assigned by GO_Central )

(Gaudet et al., 2011)

Cellular Component (4 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

located_in kinetochore

inferred from direct assay

(Schittenhelm et al., 2007, Logarinho et al., 2004, Basu et al., 1998)

located_in nucleoplasm

inferred from direct assay

(Basu et al., 1998)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

part_of bub1-bub3 complex

inferred from biological aspect of ancestor with PANTHER:PTN000103865

(assigned by GO_Central )

(Gaudet et al., 2011)

is_active_in kinetochore

inferred from biological aspect of ancestor with PANTHER:PTN000103865

(assigned by GO_Central )

(Gaudet et al., 2011)

part_of mitotic checkpoint complex

inferred from biological aspect of ancestor with PANTHER:PTN000103865

(assigned by GO_Central )

(Gaudet et al., 2011)

Gene Group (FlyBase)

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Summary (Interactive Fly)

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Bub3 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.49

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Bub3-RA

FBtr0085465

NM_058033

1236

326

Bub3-RB

FBtr0339148

NM_001300658

1362

326

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

Bub3-PA

FBpp0084831

37.4

326

6.51

NP_477381

AAF56914

Bub3-PB

FBpp0308293

37.4

326

6.51

NP_001287587

AHN57586

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

326 aa isoforms: Bub3-PA, Bub3-PB

Additional Polypeptide Data and Comments

Reported size (kDa)

327 (aa); 37 (kD observed); 37 (kD predicted)

(Basu et al., 1998)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Bub3 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Bub3_1

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 7 -- 8

anterior endoderm anlage

(Fisher et al., 2012)

head mesoderm

(Fisher et al., 2012)

hindgut anlage

(Fisher et al., 2012)

organism | ubiquitous

(Fisher et al., 2012)

posterior endoderm

(Fisher et al., 2012)

trunk mesoderm

(Fisher et al., 2012)

ventral ectoderm

(Fisher et al., 2012)

embryonic stage 9 -- 10

anterior endoderm

(Fisher et al., 2012)

inclusive hindgut primordium

(Fisher et al., 2012)

organism | ubiquitous

(Fisher et al., 2012)

posterior endoderm

(Fisher et al., 2012)

trunk mesoderm

(Fisher et al., 2012)

ventral nerve cord primordium

(Fisher et al., 2012)

embryonic stage 13 -- 16

embryonic brain

(Fisher et al., 2012)

embryonic central brain surface glia

(Fisher et al., 2012)

larval ventral nerve cord

(Fisher et al., 2012)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

No Assay Recorded

Stage

Tissue/Position (including subcellular localization)

Reference

larval stage

neuroblast

(Basu et al., 1998)

adult stage | male

spermatocyte

(Basu et al., 1998)

epitope tag

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 4 -- 5

cell

• kinetochore

Comment: Localization observed prometaphase until late anaphase of embryonic cycle 14

(Schittenhelm et al., 2007)

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

Subcellular localization to kinetochores of embryonic mitotic cells assayed using the transgenic allele Bub3^{T:Avic\GFP-EGFP}.

(Schittenhelm et al., 2007, Basu et al., 1998)

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in kinetochore

inferred from direct assay

(Schittenhelm et al., 2007, Logarinho et al., 2004, Basu et al., 1998)

located_in nucleoplasm

inferred from direct assay

(Basu et al., 1998)

Expression Deduced from Reporters

Reporter: P{gEGFP-Bub3}

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 4 -- 5

cell

• kinetochore

Comment: Localization observed prometaphase until late anaphase of embryonic cycle 14

(Schittenhelm et al., 2007)

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Bub3 in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Bub3

View exonic expression by tissue for Dmel\Bub3

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0025457

DRscDB

43490/tissue=All

EMBL-EBI Single Cell Expression Atlas

FBgn0025457

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG7581-RA

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG7581

Flygut - An atlas of the Drosophila adult midgut

FBgn0025457

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\Bub3

Stages(s) 1-3
Stages(s) 4-6
Stages(s) 7-8
Stages(s) 11-12

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 2 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 8 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Bub3

Transgenic constructs containing regulatory region of Bub3

Aberrations (Deficiencies and Duplications) ( 0 )

Inferred from experimentation ( 0 )

Inferred from location ( 0 )

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Bub3^GD9924

viable, with Scer\GAL4^Mef2.PR

Bub3^GD9924

viable, with Scer\GAL4^pnr-MD237

Bub3^GD9924

viable, with Scer\GAL4^tin.CΔ4

Bub3^GD9924

Other Phenotypes

Allele

visible, with Scer\GAL4^pnr-MD237

Bub3^GD9924

Phenotype manifest in

Allele

trichogen cell, with Scer\GAL4^pnr-MD237

Bub3^GD9924

Orthologs

Downloads

Download All DIOPT Orthologs

Download All OrthoDB Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (2)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\BUB3

13 of 15

Yes

Hsap\RAE1

1 of 15

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Bub3

13 of 15

Yes

Rattus norvegicus (Norway rat) (2)

Rnor\Bub3

6 of 13

Yes

Rnor\Rae1

1 of 13

Xenopus tropicalis (Western clawed frog) (2)

Xtro\bub3

7 of 12

Yes

Xtro\rae1

1 of 12

Danio rerio (Zebrafish) (3)

Drer\bub3

13 of 15

Yes

Drer\LOC103910025

1 of 15

Yes

Drer\rae1

1 of 15

Caenorhabditis elegans (Nematode, roundworm) (2)

Cele\bub-3

12 of 15

Yes

Cele\rae-1

1 of 15

Arabidopsis thaliana (thale-cress) (5)

Atha\BUB3.1

8 of 9

Yes

Atha\BUB3.2

8 of 9

Yes

Atha\AT1G69400

2 of 9

Yes

Atha\AT1G15850

1 of 9

Atha\RAE1

1 of 9

Saccharomyces cerevisiae (Brewer's yeast) (1)

Scer\BUB3

5 of 15

Yes

Schizosaccharomyces pombe (Fission yeast) (1)

Spom\bub3

10 of 12

Yes

Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG09190ARD )

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila suzukii

Spotted wing Drosophila

Dsuz\DS10_00011185

Drosophila suzukii

Spotted wing Drosophila

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA20454

Drosophila persimilis

Dper\GL13583

Drosophila willistoni

Dwil\GK11174

Drosophila virilis

Dvir\GJ10544

Drosophila mojavensis

Dmoj\GI24196

Drosophila grimshawi

Dgri\GH18686

Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091506NM )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Musca domestica

House fly

Mdoa\17011223

Glossina morsitans

Tsetse fly

Gmor\GMOY001233

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_09885

Mayetiola destructor

Hessian fly

Mdes\Mdes004302

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL007469

Anopheles darlingi

American malaria mosquito

Adar\ADAC005826

Anopheles darlingi

American malaria mosquito

Adar\ADAC005907

Anopheles gambiae

Malaria mosquito

Agam\AGAP010544

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ016504

Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W06UK )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Bombyx mori

Silkmoth

Bmor\BGIBMGA004646

Danaus plexippus

Monarch butterfly

Dple\DPOGS212380-PA

Heliconius melpomene

Postman butterfly

Hmel\HMEL003943

Apis florea

Little honeybee

Aflo\2758868500

Apis mellifera

Western honey bee

Amel\Bub3

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP25584

Bombus terrestris

Buff-tailed bumblebee

Bter\15207771

Linepithema humile

Argentine ant

Lhum\LH11994

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:0020da

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG000469

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_00494

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_07086

Tribolium castaneum

Red flour beetle

Tcas\Bub3

Pediculus humanus

Human body louse

Phum\PHUM515720

Rhodnius prolixus

Kissing bug

Rpro\RPRC008211

Cimex lectularius

Bed bug

Clec\CLEC007913

Cimex lectularius

Bed bug

Clec\CLEC001925

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI009048

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_01108

Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X06PT )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strigamia maritima

European centipede

Smar\SMAR000759

Ixodes scapularis

Black-legged tick

Isca\ISCW000999

Stegodyphus mimosarum

African social velvet spider

Smim\KFM75540.1

Tetranychus urticae

Two-spotted spider mite

Turt\tetur11g03390

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_310020

Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0AB8 )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Bub3h

Ciona intestinalis

Vase tunicate

Cint\ENSCING00000009630

Gallus gallus

Domestic chicken

Ggal\BUB3

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (3)

Gene Symbol

Score

Source

Alignment

3 of 10

3 of 10

2 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

cancer, models of chromosomal instability

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

BUB3; BUB3 mitotic checkpoint protein

13 of 15

603719

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

Bub3 - Cenp-C

anti tag coimmunoprecipitation, peptide massfingerprinting

(Przewloka et al., 2011)

Bub3 - ft

anti tag coimmunoprecipitation, peptide massfingerprinting

(Kwon et al., 2013)

Summary of Genetic Interactions

esyN Network Diagram

esyN Network Key:

Suppression

Enhancement

View in Interactions Browser

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Bub3

suppressible

rpr

(Muzzopappa et al., 2017)

Bub3

enhanceable

stg

(Muzzopappa et al., 2017)

Bub3

suppressible

trbl

(Muzzopappa et al., 2017)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

68354

DroID - A comprehensive database of gene and protein interactions.

FBgn0025457

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

43490

MIST (protein-protein) - An integrated Molecular Interaction Database

Bub3

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-99

Cytogenetic map

99B7-99B7

Sequence location

3R:29,674,007..29,675,421 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

99B7-99B7

Limits computationally determined from genome sequence between P{PZ}l(3)06743⁰⁶⁷⁴³ and P{PZ}ncd⁰⁵⁸⁸⁴

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

22F-23A

(Delgrossi, 1998.11.13)

99B2-99B4

(Basu, 1998.8.28, Basu et al., 1998)

99B3-99B5

(determined by in situ hybridisation)

(Andre, 1999.4.14)

Map position is based on hybridisation of a Bub3 cDNA clone to P1 clones DS04127 and DS07294.

(Basu et al., 1998)

Experimentally Determined Recombination Data

Location

3-99

(FlyBase, 2016)

3-96.7

(Comeron et al., 2012)

(Horn et al., 2003)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (8)

Bloomington

91699

w^*; P{gEGFP-Bub3}II.1

91700

w^*; P{gEGFP-Bub3}III.3

40910

y¹ v¹; P{TRiP.HMS02158}attP40

32989

y¹ sc^* v¹ sev²¹; P{TRiP.HMS00789}attP2

91698

w^*; PBac{3xP3-EYFP,p-tTA-K10}Bub3²³³/TM3, P{Ubx-lacZ.w⁺}TM3, Sb¹

FlyORF

F000892

M{UAS-Bub3.ORF.3xHA}ZH-86Fb

VDRC

v330152

P{VSH330152}attP40

v21037

w¹¹¹⁸; P{GD9924}v21037

Genomic Clones (9)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (106)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

LD23540

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0025457

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0025457

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

43490

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Morais da Silva et al., 2013, Logarinho et al., 2004, Basu et al., 1998)

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for database merge of

Additional comments

FlyBase curator comment: the insertion in the "f03381" Exelixis line (PBac{WH}CAP-D2^f03381) was originally assigned to the Bub3 gene in FBrf0179797, resulting in the "Bub3^f03381" (FBal0162743) allele. However, FBrf0184340 shows that the insertion is actually within CAP-D2.

(Bloomington Drosophila Stock Center, 2004.11.6)

Other Comments

RNAi screen using dsRNA made from templates generated with primers directed against this gene results in chromosome misalignment on the metaphase spindle when assayed in S2 cells. This phenotype can be observed when the screen is performed with or without Cdc27 dsRNA.

(Goshima et al., 2007)

dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R⁺ cell morphology.

(Kiger et al., 2003)

Origin and Etymology

Discoverer

Etymology

Identification

External Crossreferences and Linkouts ( 55 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

43490

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0025457

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0025457

DRscDB

43490/tissue=All

EMBL-EBI Single Cell Expression Atlas

FBgn0025457

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Bub3_1

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG7581

Flygut - An atlas of the Drosophila adult midgut

FBgn0025457

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

43490

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC011049

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG7581

MARRVEL_MODEL

43490

modMine - A data warehouse for the modENCODE project

FBgn0025457

SignaLink - A signaling pathway resource with multi-layered regulatory networks.

O76523

Linkouts

BioGRID - A database of protein and genetic interactions.

68354

DroID - A comprehensive database of gene and protein interactions.

FBgn0025457

DRSC - Results frm RNAi screens

FBgn0025457

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG7581-RA

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0025457

FlyMine - An integrated database for Drosophila genomics

FBgn0025457

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

43490

MIST (protein-protein) - An integrated Molecular Interaction Database

Bub3

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Synonyms and Secondary IDs (6)

Reported As

Symbol Synonym

BUB3

(Reddy et al., 2008)

CG7581

(Meadows, 2017.1.11, Çiçek et al., 2016, Schertel et al., 2013, Ni et al., 2010.12.1, Chen et al., 2008, Haussmann et al., 2008, Hughes et al., 2008, Goshima et al., 2007)

Dmbub3

(Lopes et al., 2000)

bub3

(Rahmatika et al., 2019, Muzzopappa et al., 2017, Gogendeau et al., 2015, Sabino et al., 2015, Martins et al., 2009, Wainman et al., 2009, Castellanos et al., 2008, Martins et al., 2008, Somma et al., 2008, Martins et al., 2007, Williams et al., 2007, Basu, 1998.6.30)

dBUB3

(Dobie et al., 1999)

Name Synonyms

Bub3

bub3

(Somma et al., 2008)

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