FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
CV Term Report
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General Information
Term mitotic spindle assembly checkpoint signaling ID (Ontology) GO:0007094 (Gene Ontology)
Definition A mitotic cell cycle checkpoint that delays mitotic sister chromatid separation and consequently the mitotic metaphase/anaphase transition until the spindle is correctly assembled and chromosomes are attached to the spindle. Spindle assembly checkpoint signaling begins with the activated Mph family kinase, and results in the inhibition of the Anaphase Promoting Complex and its activator Sleepy/Cdc20 by the mitotic checkpoint complex (MCC).[ PubMed:12360190 ]
Also Known As "mitotic cell cycle spindle assembly checkpoint" ; "mitotic checkpoint" ; "mitotic spindle assembly checkpoint" (for all, see Synonyms field below)
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Annotations
Records annotated with this term OR any of its CHILD TERMS
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Records annotated with this exact term (annotations to child terms are NOT included)
Data Class Field Records
Genes (FBgn)  GO_BIOLOGICAL_PROCESS      11
show Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
 Full annotation statements 
Relevant FlyBase reports
 Genes
 mitotic spindle assembly checkpoint signaling (all annotations which use CV term, excluding "NOT" statements)      11
     involved_in | mitotic spindle assembly checkpoint signaling      11
 NOT | involved_in | mitotic spindle assembly checkpoint signaling       1
Spanning Tree (Parents/Children)
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mitotic cell cycle checkpoint signaling
 |__mitotic spindle checkpoint signaling____________________________
regulation of mitotic metaphase/anaphase transition                 |
 |__negative regulation of mitotic metaphase/anaphase transition____|
spindle checkpoint signaling                                        |
 |__spindle assembly checkpoint signaling___________________________|
 |__mitotic spindle checkpoint signaling____________________________|
negative regulation of mitotic nuclear division                     |
 |__negative regulation of mitotic metaphase/anaphase transition____|
negative regulation of mitotic cell cycle phase transition          |
 |__negative regulation of mitotic metaphase/anaphase transition____|
negative regulation of metaphase/anaphase transition of cell cycle  |
 |__negative regulation of mitotic metaphase/anaphase transition____|
negative regulation of mitotic sister chromatid separation          |
 |__negative regulation of mitotic metaphase/anaphase transition____|
                                                                    mitotic spindle assembly checkpoint signaling  13 rec.
                                                                     |__regulation of mitotic cell cycle spindle assembly checkpoint 4 rec.
                                                                         |__negative regulation of mitotic spindle assembly checkpoint signaling(+)
                                                                         |__positive regulation of mitotic cell cycle spindle assembly checkpoint(+) 1 rec.
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Is a negative regulation of mitotic metaphase/anaphase transition
spindle assembly checkpoint signaling
mitotic spindle checkpoint signaling
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Synonyms
  • "Dma1-dependent checkpoint" NARROW
    "Mad2-dependent checkpoint" NARROW
    "mitotic cell cycle spindle assembly checkpoint" EXACT
    "mitotic checkpoint" EXACT
    "mitotic spindle assembly checkpoint" EXACT
    "mitotic spindle assembly checkpoint signalling" EXACT
    "SAC-independent checkpoint" NARROW
    "signal transduction involved in Dma1-dependent checkpoint" NARROW
    "signal transduction involved in mitotic cell cycle spindle assembly checkpoint" EXACT
    "signal transduction involved in mitotic spindle assembly checkpoint" EXACT
    "signal transduction involved in SAC-independent checkpoint" NARROW
    "signaling cascade involved in Dma1-dependent checkpoint" NARROW
    "signaling cascade involved in SAC-independent checkpoint" NARROW
    "signaling pathway involved in Dma1-dependent checkpoint" RELATED
    "signaling pathway involved in SAC-independent checkpoint" RELATED
    "signalling cascade involved in Dma1-dependent checkpoint" NARROW
    "signalling cascade involved in SAC-independent checkpoint" NARROW
    "signalling pathway involved in Dma1-dependent checkpoint" RELATED
    "signalling pathway involved in SAC-independent checkpoint" RELATED
Secondary IDs
hide External Crossreferences & Linkouts
Reactome:R-HSA-69618 "Mitotic Spindle Checkpoint"