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FB2026_01
,
released March 12, 2026
hrt, l(3)84Eh, hearty, vco
dual specificity phosphatase KH-1 subfamily JNK specific phosphatase - mediates a feedback loop that regulates the Jun-N-terminal kinase pathway - functions in dorsal closure
Please see the JBrowse view of Dmel\puc for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.49
2.9 (northern blot)
None of the polypeptides share 100% sequence identity.
476 (aa); 58 (kD predicted)
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\puc using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
JBrowse - Visual display of RNA-Seq signals
View Dmel\puc in JBrowsePlease Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
dsRNA directed against puc inhibits protein secretion in S2 cells, but has no apparent effect on Golgi organisation.
dsRNA directed against this gene has been used in a screen for genes required for constitutive protein secretion.
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a phenotype when assayed in Kc167 cells: change from round to spindle-shaped, with the formation of F-actin puncta and microtubule extensions. Alterations of cell shape are also evident in S2R+ cells.
Proper levels of puc activity in the follicle cells are critical for the production of a normal egg.
Either reduced or increased puc activity results in incomplete nurse cell dumping and aberrant dorsal appendages.
Loss of function and gain of function mutants in puc cause planar polarity phenotypes in the eye.
Candidate gene for quantitative trait (QTL) locus determining bristle number.
puc has a negative regulatory role in thorax closure during metamorphosis.
puc is both a repressor and a target of hep function in the leading edge. The combined and antagonistic functions of hep and puc maintain appropriate levels of puc and dpp activities in migrating epithelia during dorsal closure. These results indicate a leading edge cell identity and dorsal closure depend on a balance between bsk activation and puc repression.
The General Council of the Velcro Group Corporation prohibited the use of the name 'velcro' for this gene, as that would constitute an infringement of trademark.
Mutation in puc affects neuronal connections, affecting fasciculation.
puc is required for PNS development in the embryo.
Source for merge of: puc hrt
Source for merge of: puc l(3)j4E1
Source for identity of: puc CG7850
