belongs to a subgroup of serine protease homologues with an inactive catalytic site - functions extracellularly during dorsal closure as an antagonist of the JNK pathway - regulates the polarized localization of laminin A during the development of epithelial polarity
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.47
The CLIP domain consists of 37-55 residues which are 'knitted' together usually by 3 conserved disulfide bonds forming a clip-like compact structure.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\scaf using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\scaf in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
The gene is named "scarface" based on the phenotype of homozygous adult escapers, which have what appears to be "scarring" around the mouthparts.