FB2026_03 , released September 17, 2026
FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term proteolysis ID (Ontology) GO:0006508 (Gene Ontology)
Definition The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
Also Known As "peptidolysis"
Comment
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Records annotated with this term OR any of its CHILD TERMS

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Direct annotations: records annotated with this exact term (child terms are NOT included)
Data ClassFieldDirect annotations
Genes (FBgn)GO_BIOLOGICAL_PROCESS
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 Gene Groups Genes
 proteolysis (all annotations which use CV term, excluding "NOT" statements)
     involved_in | proteolysis       --
 NOT | involved_in | proteolysis       --
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Vocabulary search
macromolecule metabolic process__
primary metabolic process________|
                                 protein metabolic process
                                  |__proteolysis  624 rec.
                                      |__membrane protein proteolysis 15 rec.
                                      |   |__membrane protein ectodomain proteolysis(+) 11 rec.
                                      |   |__membrane protein intracellular domain proteolysis(+) 5 rec.
                                      |__protein processing 91 rec.
                                      |   |__activation of plasma proteins involved in acute inflammatory response
                                      |   |__CAAX-box protein processing 7 rec.
                                      |   |__dibasic protein processing(+)
                                      |   |__mitochondrial protein processing 5 rec.
                                      |   |__Notch receptor processing, ligand-independent
                                      |   |__protein autoprocessing 6 rec.
                                      |   |__protein processing in phagocytic vesicle(+)
                                      |   |__protein splicing(+) 1 rec.
                                      |   |__regulation of protein processing(+) 4 rec.
                                      |   |__signaling receptor ligand precursor processing(+) 20 rec.
                                      |   |__vacuolar protein processing
                                      |   |__zymogen activation(+) 8 rec.
                                      |__proteolysis associated with antigen processing and presentation
                                      |   |__proteasomal proteolysis associated with antigen processing and presentation
                                      |   |__proteolysis by cytosolic proteases associated with antigen processing and presentation
                                      |   |__proteolysis within endoplasmic reticulum associated with antigen processing and presentation
                                      |   |__proteolysis within endosome associated with antigen processing and presentation
                                      |   |__proteolysis within lysosome associated with antigen processing and presentation
                                      |   |__regulation of proteolysis associated with antigen processing and presentation(+)
                                      |__regulation of proteolysis 41 rec.
                                      |   |__negative regulation of proteolysis(+) 24 rec.
                                      |   |__positive regulation of proteolysis(+) 5 rec.
                                      |   |__regulation of membrane protein ectodomain proteolysis(+) 1 rec.
                                      |   |__regulation of peptidase activity(+) 2 rec.
                                      |   |__regulation of protein processing(+) 4 rec.
                                      |   |__regulation of proteolysis associated with antigen processing and presentation(+)
                                      |__self proteolysis
                                          |__calcium-dependent self proteolysis
                                          |__sodium-dependent self proteolysis
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Is a protein metabolic process
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Synonyms
  • "ATP-dependent proteolysis" NARROW
    "peptidolysis" EXACT
Secondary IDs
hide External Crossreferences & Linkouts
Wikipedia:Proteolysis