FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
CV Term Report
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General Information
Term proteolysis ID (Ontology) GO:0006508 (Gene Ontology)
Definition The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
Also Known As "peptidolysis"
Comment
Links to External Ontologies
  QuickGO data     AmiGO data
Annotations
Records annotated with this term OR any of its CHILD TERMS
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Records annotated with this exact term (annotations to child terms are NOT included)
Data Class Field Records
Genes (FBgn)  GO_BIOLOGICAL_PROCESS     497
show Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
 Full annotation statements 
Relevant FlyBase reports
 Gene Groups Genes
 proteolysis (all annotations which use CV term, excluding "NOT" statements)      56    497
     involved_in | proteolysis       --     489
 NOT | involved_in | proteolysis       --       7
Spanning Tree (Parents/Children)
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macromolecule metabolic process__
primary metabolic process________|
                                 protein metabolic process
                                  |__proteolysis  628 rec.
                                      |__membrane protein proteolysis 15 rec.
                                      |   |__membrane protein ectodomain proteolysis(+) 11 rec.
                                      |   |__membrane protein intracellular domain proteolysis(+) 5 rec.
                                      |   |__membrane protein proteolysis involved in retrograde protein transport, ER to cytosol
                                      |__protein processing 93 rec.
                                      |   |__activation of plasma proteins involved in acute inflammatory response
                                      |   |__CAAX-box protein processing 7 rec.
                                      |   |__dibasic protein processing(+)
                                      |   |__mitochondrial protein processing 5 rec.
                                      |   |__Notch receptor processing, ligand-independent
                                      |   |__protein autoprocessing 6 rec.
                                      |   |__protein processing in phagocytic vesicle(+)
                                      |   |__protein splicing(+) 1 rec.
                                      |   |__regulation of protein processing(+) 5 rec.
                                      |   |__signaling receptor ligand precursor processing(+) 20 rec.
                                      |   |__vacuolar protein processing 1 rec.
                                      |   |__zymogen activation(+) 9 rec.
                                      |__proteolysis associated with antigen processing and presentation
                                      |   |__proteasomal proteolysis associated with antigen processing and presentation
                                      |   |__proteolysis by cytosolic proteases associated with antigen processing and presentation
                                      |   |__proteolysis within endoplasmic reticulum associated with antigen processing and presentation
                                      |   |__proteolysis within endosome associated with antigen processing and presentation
                                      |   |__proteolysis within lysosome associated with antigen processing and presentation
                                      |   |__regulation of proteolysis associated with antigen processing and presentation(+)
                                      |__regulation of proteolysis 42 rec.
                                      |   |__negative regulation of proteolysis(+) 24 rec.
                                      |   |__positive regulation of proteolysis(+) 6 rec.
                                      |   |__regulation of membrane protein ectodomain proteolysis(+) 1 rec.
                                      |   |__regulation of peptidase activity(+) 2 rec.
                                      |   |__regulation of protein processing(+) 5 rec.
                                      |   |__regulation of proteolysis associated with antigen processing and presentation(+)
                                      |__self proteolysis
                                          |__calcium-dependent self proteolysis
                                          |__sodium-dependent self proteolysis
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Is a protein metabolic process
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Synonyms
  • "ATP-dependent proteolysis" NARROW
    "peptidolysis" EXACT
Secondary IDs
hide External Crossreferences & Linkouts
Wikipedia:Proteolysis