FlyBase Gene Report: Dmel\flz

General Information

Symbol

Dmel\flz

Species

D. melanogaster

Name

filzig

Annotation Symbol

CG8213

Feature Type

protein_coding_gene

FlyBase ID

FBgn0286782

Gene Model Status

Current

Stock Availability

12 publicly available

Gene Summary

Probable endopeptidase. In tracheal terminal cells, acts downstream of ich to regulate seamless tube growth and/or maintenance probably by processing lumenal matrix proteins. (UniProt, B7YZU2)

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Gene Group
UniProtKB
Red Book
Interactive Fly

Also Known As

lint, lumens interrupted

Key Links

Genomic Location

Cytogenetic map

44F12-45A1

Sequence location

2R:8,969,346..8,985,900 [-]

Recombination map

2-59

RefSeq locus

NT_033778 REGION:8969346..8985900

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (7 terms)

Molecular Function (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

enables serine-type endopeptidase activity

inferred from sequence model

(Cao and Jiang, 2018, Ross et al., 2003)

inferred from electronic annotation with InterPro:IPR001254, InterPro:IPR018114

(InterPro Project Members, 2004-)

enables serine-type peptidase activity

inferred from biological aspect of ancestor with PANTHER:PTN002543071

(GO Reference Genome Project, 2011-)

Biological Process (4 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

involved_in lumen formation, open tracheal system

inferred from expression pattern

(Rosa et al., 2018)

involved_in trachea morphogenesis

inferred from mutant phenotype

(Rosa et al., 2018)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

involved_in protein processing

inferred from biological aspect of ancestor with PANTHER:PTN002543071

(GO Reference Genome Project, 2011-)

involved_in proteolysis

inferred from electronic annotation with InterPro:IPR001254, InterPro:IPR018114

(InterPro Project Members, 2004-)

inferred from sequence model

(Ross et al., 2003)

Cellular Component (1 term)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

located_in perivitelline space

inferred from high throughput direct assay

(Lye et al., 2014)

Terms Based on Predictions or Assertions (0 terms)

Gene Group (FlyBase)

S1A SERINE PROTEASES - TRYPSIN-LIKE

Protein Family (UniProt)

Belongs to the peptidase S1 family. (B7YZU2)

Protein Signatures (InterPro)

Summaries

Gene Group (FlyBase)

S1A SERINE PROTEASES - TRYPSIN-LIKE -: Trypsin-like serine proteases of the S1A family are endopeptidases that cleave amide substrates following Arginine or Lysine at the P1 position. (Adapted from FBrf0239469).

Protein Function (UniProtKB)

Probable endopeptidase. In tracheal terminal cells, acts downstream of ich to regulate seamless tube growth and/or maintenance probably by processing lumenal matrix proteins.

(UniProt, B7YZU2)

Phenotypic Description (Red Book; Lindsley and Zimm 1992)

flz: filzig

Embryonic lethal; denticles and hairs of larvae have abnormal fuzzy texture. Mouth hooks poorly developed.

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\flz for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry B7YZU2)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.49

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

flz-RB

FBtr0273384

NM_136591

6439

1674

flz-RC

FBtr0273385

NM_001144150

6171

1693

flz-RD

FBtr0339307

NM_001299292

6637

1430

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

flz-PB

FBpp0271892

180.6

1674

6.77

FBpp0271893

182.7

1693

6.80

FBpp0308413

154.3

1430

6.72

A0A0B4LFV3

NP_001286221

AHN56019

Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

B7YZU2

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\flz using the Feature Mapper tool.

External Data

Crossreferences

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

0.01

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 13

posterior spiracle primordium

(Rosa et al., 2018)

foregut primordium

(Rosa et al., 2018)

embryonic stage 15 -- 16

embryonic/larval tracheal section

(Rosa et al., 2018)

embryonic/larval foregut

(Rosa et al., 2018)

embryonic/larval hindgut

(Rosa et al., 2018)

embryonic/larval epidermis

(Rosa et al., 2018)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in perivitelline space

inferred from high throughput direct assay

(Lye et al., 2014)

Expression Deduced from Reporters

Reporter: Mi{Trojan-GAL4.1}flz^{MI04680-TG4.1}

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult tracheal system

(Lee et al., 2018)

Reporter: PBac{681.P.FSVS-1}flz^CPTI001902

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult brain cell body rind

(Knowles-Barley, 2011.8.24)

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\flz in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\flz

View exonic expression by tissue for Dmel\flz

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

35902/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0286782

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0033359

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0286782

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG8213

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 23 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 8 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of flz

Transgenic constructs containing regulatory region of flz

Aberrations (Deficiencies and Duplications) ( 15 )

Inferred from experimentation ( 15 )

Gene not disrupted in

Df(2R)44CE

(Mohr and Boswell, 2002)

Df(2R)Np5

(Mohr and Boswell, 2002)

Df(2R)w45-30n

(Mohr and Boswell, 2002)

Df(2R)w73-2

(Mohr and Boswell, 2002)

Inferred from location ( 7 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal | recessive

lethal - all die before end of larval stage, with Scer\GAL4^btl.PU

lethal - all die before end of pupal stage, with Scer\GAL4^pnr-MD237

flz^GD1886

lethal - all die during embryonic stage

lethal - all die during embryonic stage | recessive

flz^unspecified

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

flz^GD1886

viable, with Scer\GAL4^Mef2.PR

flz^GD1886

viable, with Scer\GAL4^tin.CΔ4

flz^GD1886

Other Phenotypes

Allele

abnormal feeding behavior | third instar larval stage, with Scer\GAL4^Ilp2.PR

flz^GD1886

abnormal starvation stress response | adult stage, with Scer\GAL4^Ilp2.PR

flz^GD1886

decreased body size | adult stage, with Scer\GAL4^Ilp2.PR

decreased body size | larval stage, with Scer\GAL4^btl.PU

decreased body size | pupal stage, with Scer\GAL4^Ilp2.PR

decreased cell size | third instar larval stage, with Scer\GAL4^Ilp2.PR

flz^GD1886

some die during embryonic stage

some die during embryonic stage | recessive

flz^unspecified

some die during pupal stage, with Scer\GAL4^pnr-MD237

flz^GD1886

Phenotype manifest in

Allele

cephalopharyngeal skeleton

flz¹

denticle

flz¹

microchaeta

flz¹

mouth hook

flz^unspecified

terminal tracheal cell, with Scer\GAL4^bs.PM

terminal tracheal cell | somatic clone

terminal tracheal cell | third instar larval stage, with Scer\GAL4^drm.7.1

flz^UAS.cRa

terminal tracheal cell | third instar larval stage, with Scer\GAL4^Ilp2.PR

flz^GD1886

tracheal branch | decreased number | third instar larval stage, with Scer\GAL4^btl.PU

flz^GD1886

tracheal branch | third instar larval stage, with Scer\GAL4^btl.PU

flz^GD1886

tracheal branch | third instar larval stage, with Scer\GAL4^Ilp2.PR

flz^GD1886

trichome | embryonic stage

flz^unspecified

ventral denticle belt

flz^unspecified

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (92)

Hsap\F11

2 of 14

Yes

Hsap\KLKB1

2 of 14

Yes

Hsap\PRSS8

2 of 14

Yes

Hsap\TMPRSS11D

2 of 14

Yes

Hsap\TPSAB1

2 of 14

Yes

Hsap\TPSB2

2 of 14

Yes

Hsap\TPSD1

2 of 14

Yes

Hsap\TPSG1

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\GZMB

1 of 14

Hsap\GZMH

1 of 14

Hsap\GZMM

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\PROZ

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (76)

Rnor\F11

2 of 14

Yes

Rnor\Klkb1

2 of 14

Yes

Rnor\Prss29

2 of 14

Yes

Rnor\Tmprss9

2 of 14

Yes

Rnor\Tpsg1

2 of 14

Yes

Rnor\Acr

1 of 14

Rnor\C2

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Rnor\Masp2

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Mus musculus (laboratory mouse) (87)

Mmus\Prss8

2 of 14

Yes

Mmus\Prss21

2 of 14

Yes

Mmus\Prss22

2 of 14

Yes

Mmus\Prss27

2 of 14

Yes

Mmus\Prss28

2 of 14

Yes

Mmus\Prss29

2 of 14

Yes

Mmus\Prss30

2 of 14

Yes

Mmus\Prss32

2 of 14

Yes

Mmus\Prss36

2 of 14

Yes

Mmus\Prss48

2 of 14

Yes

Mmus\Tmprss11d

2 of 14

Yes

Mmus\Tpsab1

2 of 14

Yes

Mmus\Tpsb2

2 of 14

Yes

Mmus\Tpsg1

2 of 14

Yes

Mmus\2210010C04Rik

1 of 14

Mmus\Acr

1 of 14

Mmus\C1s1

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

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1 of 14

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1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

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1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (68)

Xtro\hoxc4

2 of 13

Yes

Xtro\LOC101732100

2 of 13

Yes

Xtro\LOC108648818

2 of 13

Yes

Xtro\LOC116407662

2 of 13

Yes

Xtro\tmprss9

2 of 13

Yes

Xtro\tpsg1

2 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

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1 of 13

1 of 13

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1 of 13

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1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Danio rerio (Zebrafish) (62)

Drer\LOC100331291

3 of 14

Yes

Drer\tmprss9

3 of 14

Yes

Drer\zmp:0000001114

3 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

Yes

Drer\cela1.2

1 of 14

Drer\cfd

1 of 14

Drer\cfi

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (13)

Cele\try-1

2 of 14

Yes

Cele\D1081.3

1 of 14

Yes

Cele\D1081.19

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (251)

Agam\AgaP_AGAP008995

9 of 12

Yes

Agam\AgaP_AGAP008994

5 of 12

Yes

2 of 12

2 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

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1 of 12

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1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

Agam\AgaP_AGAP004639

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

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1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

1 of 12

1 of 12

1 of 12

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1 of 12

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1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

1 of 12

1 of 12

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1 of 12

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1 of 12

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1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (0)

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:flz. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (229)

CG8172

6 of 13

5 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

tpr

3 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

Sp7

2 of 13

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

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1 of 13

1 of 13

1 of 13

1 of 13

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Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

ich

suppressible

flz

(Rosa et al., 2018)

External Data

Linkouts

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Regulation of Complement cascade

Class of Gene

gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-59

Cytogenetic map

44F12-45A1

Sequence location

2R:8,969,346..8,985,900 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

44F12-45A1

Limits computationally determined from genome sequence between P{lacW}babo^k16912 and P{lacW}l(2)k16529^k16529

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

The flz complementation group maps to the genomic interval 2R:8976399..9031045 , release 6 genome (left limit from complementation mapping against Df(2R)BSC271, right limit from complementation mapping against Df(2R)BSC268).

(Kahsai and Cook, 2018)

Experimentally Determined Recombination Data

Location

2-59

(FlyBase, 2016, Tearle and Nusslein-Volhard, 1987)

2-58.0

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (12)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

58277

y¹ v¹; P{TRiP.HMJ22360}attP40

38387

y¹ w^*; Mi{MIC}flz^MI04680/SM6a

3271

cn¹ flz¹ bw¹ speck¹/CyO

34045

cn¹ flz² bw¹ speck¹/CyO

67456

y¹ w^*; Mi{Trojan-GAL4.1}flz^{MI04680-TG4.1}/SM6a

55350

y¹ sc^* v¹ sev²¹; P{TRiP.HMC04037}attP40

Kyoto

115246

w¹¹¹⁸; PBac{681.P.FSVS-1}flz^CPTI001902

106950

cn¹ flz¹ bw¹ speck¹/CyO

NIG-Fly

HMJ22360

y¹ v¹; P{TRiP.HMJ22360}attP40/CyO

2RG-0265

y² VhaAC39-1^cho-1 v¹; P{U6-flz.NIG.sgRNA}attP40/CyO

VDRC

v107288

P{KK105169}VIE-260B

v7372

w¹¹¹⁸; P{GD1886}v7372/TM3

Genomic Clones (18)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (17)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

LD43328

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Relationship to Other Genes

Source for database merge of

Source for merge of: flz lint

(Kahsai and Cook, 2018)

Additional comments

Nomenclature History

Source for database identify of

Source for identity of: lint CG8213

(Rosa et al., 2018)

Nomenclature comments

Etymology

Named 'lumens interrupted' because terminal cell-specific knockdown induces numerous apical membrane discontinuities along each tracheal branch, as well as seamless tube cysts.

(Rosa et al., 2018)

Synonyms and Secondary IDs (8)

Reported As

Symbol Synonym

CG8213

(National Institute of Genetics Fly Stocks, 2022-, Kahsai and Cook, 2018, Lee et al., 2018, Rosa et al., 2018, Gene Disruption Project members, 2016-, Veillard et al., 2016, Hosono et al., 2015, Nam et al., 2012, Cook et al., 2010.2.12, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Haussmann et al., 2008, Shah et al., 2008, Buszczak et al., 2007, Christophides et al., 2002)

SP44

(Ross et al., 2003)

c-SP44

(Ross et al., 2003)

cSP44

(Cao and Jiang, 2018)

flz

(Drees et al., 2023, Kumar et al., 2021, Kahsai and Cook, 2018)

lint

(Pathak et al., 2021, Drees et al., 2019, Rosa et al., 2018)

Name Synonyms

filzig

(Wieschaus and Nüsslein-Volhard, 2016)

lumens interrupted

(Rosa et al., 2018)

Secondary FlyBase IDs

FBgn0000712
FBgn0033359

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 35 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

35902

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

B7YZU2

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

B7YZU2

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

B7YZU2

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

35902/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0286782

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0286782

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG8213

MARRVEL_MODEL - MARRVEL (model organism gene)

35902

Linkouts

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0033359

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0286782

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG8213

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC033856

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Regulation of Complement cascade

References (60)

The following external sites may use different assemblies or annotations than FlyBase.

0.01

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