- Tools
- Downloads
- Links
- Community
- About
- Help
FB2025_05
,
released December 11, 2025
fs(1)M18, fs(1)gd, fs(1)573, SP186
a maternally supplied protease involved in establishment of dorsal/ventral polarity - targets Snake
Please see the JBrowse view of Dmel\gd for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.51
Gene model reviewed during 5.45
Gene model reviewed during 5.41
Gene model reviewed during 5.39
Gene model reviewed during 6.03
Alternative translation stop created by use of multiphasic reading frames within coding region.
2.1 (northern blot)
528 (aa); 34, 30, 28 (kD observed); 59 (kD predicted)
Proteolytically activated by the protease ndl.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\gd using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
gd protein is detected in ovaries and early embryos on western blots. Levels are highest in ovaries and it is essentially gone by 4 hours of embryogenesis.
JBrowse - Visual display of RNA-Seq signals
View Dmel\gd in JBrowse1-38
1-37.1
1-36.78
1-
1-36.8
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
polyclonal
Interallelic complementation data suggests that there are two discrete functional domains of gd.
Some of the proteins of apico-lateral junctions are required both for apico-basal cell polarity and for the signalling mechanisms controlling cell proliferation, whereas others are required more specifically in cell-cell signalling.
Mutuants cause maternal-effect lethality. Embryos produced by homozygous females exhibit hyperplasia of dorsal cuticular elements and aplasia of ventral elements. Polarity of the egg shell unaffected. Temperature-sensitive period of temperature-sensitive alleles begins several hours prior to oviposition and persists until 1.5 h after fertilization. Five of eight mutants classed as weak on the basis of filzkorper development; these five tend to be more dorsalized in posterior than in anterior parts of the embryo, as the setal bands become progressively narrowed posteriorly.
Flies heterozygous for RpII215Ubl and a gd mutation show no reduction in fertility. gd therefore shows no dominant effects.
Mutations at gd causes dorsalised embryonic phenotypes.
Gastrula exhibits excessive furrowing both dorsally and ventrally.
Source for identity of: gd CG1505
