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Citation
Konrad, K.D., Goralski, T.J., Mahowald, A.P., Marsh, J.L. (1998). The gastrulation defective gene of Drosophila melanogaster is a member of the serine protease superfamily.  Proc. Natl. Acad. Sci. U.S.A. 95(12): 6819--6824.
FlyBase ID
FBrf0102954
Publication Type
Research paper
Abstract

The establishment of dorsal-ventral polarity in the oocyte involves two sets of genes. One set belongs to the gurken-torpedo signaling pathway and affects the development of the egg chorion as well as the polarity of the embryo. The second set of genes affects only the dorsal-ventral polarity of the embryo but not the eggshell. gastrulation defective is one of the earliest acting of this second set of maternally required genes. We have cloned and characterized the gastrulation defective gene and determined that it encodes a protein structurally related to the serine protease superfamily, which also includes the Snake, Easter, and Nudel proteins. These data provide additional support for the involvement of a protease cascade in generating an asymmetric signal (i.e., asymmetric SpƤtzle activity) during establishment of dorsal-ventral polarity in the Drosophila embryo.

PubMed ID
PubMed Central ID
PMC22648 (PMC) (EuropePMC)
Related Publication(s)
Review

Paper alert.
Jones, 1998, Curr. Opin. Genet. Dev. 8(4): 377 [FBrf0104614]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Proc. Natl. Acad. Sci. U.S.A.
    Title
    Proceedings of the National Academy of Sciences of the United States of America
    Publication Year
    1915-
    ISBN/ISSN
    0027-8424
    Data From Reference
    Aberrations (6)
    Alleles (12)
    Genes (9)
    Transgenic Constructs (2)