FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
Allele: Dmel\gd4
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General Information
Symbol
Dmel\gd4
Species
D. melanogaster
Name
FlyBase ID
FBal0005012
Feature type
allele
Associated gene
Dmel\gd
Associated Insertion(s)
Carried in Construct
Also Known As
13-935
Key Links
Genomic Maps

Allele class

amorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - genetic evidence

(Ponomareff et al., 2001)
Mutagen
ethyl methanesulfonate
(Konrad et al., 1988, Tearle and Nusslein-Volhard, 1987, Mohler, 1977)
Progenitor genotype
Cytology
Description

Nucleotide substitution: G1309A. Mutation results in a splicing error at the intron IV acceptor site, resulting in a 15 amino acid residue deletion (ΔF359-S373).

(Ponomareff et al., 2001)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
X:11,986,297..11,986,297 [-]
Nucleotide change:

G11986297A

Reported nucleotide change:

G1309A

Comment:

Mutation results in a splicing error at the intron IV acceptor site, resulting in a 15 amino acid residue deletion; the next AG is in frame and is 15 amino acids downstream.

(Ponomareff et al., 2001)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      100% of embryos derived from homozygous or gd4/Df(1)KA10 females have a class I phenotype (they are strongly dorsalised, lacking both ventral denticles and filzkorper).

      (Ponomareff et al., 2001)

      Eggs from gd4/Df mothers do not have apparent vitelline membrane defects.

      (LeMosy and Hashimoto, 2000)

      Transheterozygous combinations of gd mutations produce a range of cuticular phenotypes, ranging from cuticle only having dorsal characteristics, to cuticle having some ventral characteristics, such as ventral setal belts, depending on the alleles used. Some combinations of alleles complement each other.

      (Konrad et al., 1988)

      Embryonic defects detectable at gastrulation.

      (Mohler and Carroll, 1984)

      Homozygous females lay eggs that fail to hatch.

      (Mohler, 1977)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      gd6

      (Mohler, 1977)

      gd3

      (Mohler, 1977)

      gd2

      (Mohler, 1977)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Mohler.

      Comments
      Comments

      Approximate order of allelic severity, from weakest to strongest is: gd5 > gd1 > gd3 > gd6 > gd2 > gd4 > gd7 = gd8 = gd9 = gd10 = gd11 = gd12.

      (Konrad et al., 1988)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      13-935
      (Mohler and Carroll, 1984, Mohler, 1977)
      fs(1)M1813-935
      gd13-935
      (Tearle and Nusslein-Volhard, 1987)
      gd4
      Name Synonyms
      Secondary FlyBase IDs
        References (9)