FB2026_02 , released June 18, 2026
Allele: Dmel\gd3
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General Information
Symbol
Dmel\gd3
Species
D. melanogaster
Name
FlyBase ID
FBal0005011
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
12-4955
Key Links
Genomic Maps

Nature of the Allele
Progenitor genotype
Cytology
Description

Nucleotide substitution: C362T. Amino acid replacement: P104S.

Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Nucleotide change:

C11987325T

Reported nucleotide change:

C362T

Amino acid change:

P104S | gd-PC; P107S | gd-PD; P104S | gd-PE; P104S | gd-PF

Reported amino acid change:

P104S

Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

9% of embryos derived from homozygous females have a class I phenotype (they are strongly dorsalised, lacking both ventral denticles and filzkorper), 7% have a class II phenotype (they lack ventral denticles but have filzkorper), 4% have a class III phenotype (they have ventral denticles) and 0% have a class H phenotype (they are phenotypically normal and hatch). 44% of embryos derived from gd3/Df(1)KA10 females have a class I phenotype, 6% have a class II phenotype, 0% have a class III phenotype and 0% have a class H phenotype.

Transheterozygous combinations of gd mutations produce a range of cuticular phenotypes, ranging from cuticle only having dorsal characteristics, to cuticle having some ventral characteristics, such as ventral setal belts, depending on the alleles used. Some combinations of alleles complement each other. Homozygous gd3 females show temperature sensitivity in the amount of hatching, and the severity of their offspring's dorsalised phenotype.

Embryonic defects detectable at gastrulation.

Homozygous females lay eggs that fail to hatch.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer

Mohler.

Comments
Comments

Temperature shift experiments show that functional gd is required late in oogenesis and early in embryogenesis.

Approximate order of allelic severity, from weakest to strongest is: gd5 > gd1 > gd3 > gd6 > gd2 > gd4 > gd7 = gd8 = gd9 = gd10 = gd11 = gd12.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (4)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (6)