Nucleotide substitution: C362T. Amino acid replacement: P104S.
C11987325T
C362T
P104S | gd-PC; P107S | gd-PD; P104S | gd-PE; P104S | gd-PF
P104S
9% of embryos derived from homozygous females have a class I phenotype (they are strongly dorsalised, lacking both ventral denticles and filzkorper), 7% have a class II phenotype (they lack ventral denticles but have filzkorper), 4% have a class III phenotype (they have ventral denticles) and 0% have a class H phenotype (they are phenotypically normal and hatch). 44% of embryos derived from gd3/Df(1)KA10 females have a class I phenotype, 6% have a class II phenotype, 0% have a class III phenotype and 0% have a class H phenotype.
Transheterozygous combinations of gd mutations produce a range of cuticular phenotypes, ranging from cuticle only having dorsal characteristics, to cuticle having some ventral characteristics, such as ventral setal belts, depending on the alleles used. Some combinations of alleles complement each other. Homozygous gd3 females show temperature sensitivity in the amount of hatching, and the severity of their offspring's dorsalised phenotype.
Embryonic defects detectable at gastrulation.
Homozygous females lay eggs that fail to hatch.
Mohler.
Temperature shift experiments show that functional gd is required late in oogenesis and early in embryogenesis.
Approximate order of allelic severity, from weakest to strongest is: gd5 > gd1 > gd3 > gd6 > gd2 > gd4 > gd7 = gd8 = gd9 = gd10 = gd11 = gd12.