FB2026_02 , released June 18, 2026
Allele: Dmel\gd7
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General Information
Symbol
Dmel\gd7
Species
D. melanogaster
Name
FlyBase ID
FBal0005015
Feature type
allele
Associated gene
Dmel\gd
Associated Insertion(s)
Carried in Construct
Also Known As
14-743
Key Links
Genomic Maps

Allele class

amorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - genetic evidence

(Ponomareff et al., 2001)
Mutagen
ethyl methanesulfonate
(Konrad et al., 1988, Tearle and Nusslein-Volhard, 1987, Mohler, 1977)
Progenitor genotype
Cytology
Description

Nucleotide substitution: G1768A. Amino acid replacement: G484D.

(Ponomareff et al., 2001)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
X:11,985,919..11,985,919 [-]
Nucleotide change:

G11985919A

Reported nucleotide change:

G1768A

Amino acid change:

G484D | gd-PC; G487D | gd-PD; G484D | gd-PF

Reported amino acid change:

G484D

(Ponomareff et al., 2001)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      100% of embryos derived from homozygous or gd7/Df(1)KA10 females have a class I phenotype (they are strongly dorsalised, lacking both ventral denticles and filzkorper).

      (Ponomareff et al., 2001)

      Embryos derived from homozygous females lack ventral structures such as the mesoderm and neurogenic ectoderm.

      (Ashe et al., 2000)

      Embryos laid by homozygous gd7 mothers, fail to undergo ventral and lateral development, therefore developing the dorsalized phenotype evident during gastrulation and in the cuticle pattern.

      (Han et al., 2000)

      Embryos derived from homozygous females have very few amnioserosa cells.

      (Ashe and Levine, 1999)

      Bacterially challenged mutants exhibit a wild type Drs response. Pattern of response of CecA1 and CecA2 parallels that of Drs. Dpt and Dro remain fully inducible and pattern of expression of AttA and Def in intermediate.

      (Lemaitre et al., 1996)

      Mutant embryos respond to injected purified polarizing activity (spz).

      (Schneider et al., 1994)

      Phenotype of strong alleles indistinguishable from that of dl.

      (Lindsley and Zimm, 1992)

      Embryos were not rescued by injection of perivitelline fluid from dl donors but were rescued by Tl donors.

      (Stein and Nusslein-Volhard, 1992)

      Transheterozygous combinations of gd mutations produce a range of cuticular phenotypes, ranging from cuticle only having dorsal characteristics, to cuticle having some ventral characteristics, such as ventral setal belts, depending on the alleles used. Some combinations of alleles complement each other.

      (Konrad et al., 1988)

      Embryos derived from homozygous females are dorsalised.

      (Carroll et al., 1987)

      Embryonic defects detectable at gastrulation.

      (Mohler and Carroll, 1984)

      Pattern of ftz protein stripes in homozygous females identical to that of other maternal dorsalizing mutants (Carroll, Winslow, Twombly and Scott, 1987).

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Enhanced by
      Statement
      Reference

      Tl3, gd7 has embryonic epidermis phenotype, enhanceable by Dp(2;1)G146

      (Araujo and Bier, 2000)
      Other
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      13% of embryos from mutant mothers show weakly ventralised, as opposed to strongly ventralised, mutant phenotype. The penetrance of this suppression is increased to 50-80% when dpp dosage in increased with dppBP.hs.

      Embryos from gd7/gd7;Tl3/+ mothers are lateralized. When the mothers are also duplicated for dpp, embryos show a more strongly lateralized phenotype with a more dorsal character - fewer, finer or absent denticles and a lateralized gastrulation pattern where the germband does not extend dorsally and no polarity is visible.

      Cuticles of embryos collected from gd7/gd7;grkunspecified;Tl3 mothers have a more ventral character than those derived from gd7/gd7;Tl3 mothers.

      Embryos from gd7/gd7;Tl3/+ mothers are lateralized. When the mothers are also duplicated for dpp, embryos show a more strongly lateralized phenotype with a more dorsal character - fewer, finer or absent denticles and a lateralized gastrulation pattern where the germband does not extend dorsally and no polarity is visible. Cuticles of embryos collected from gd7/gd7;grkunspecified;Tl3 have a more ventral character than those derived from gd7/gd7;Tl3 mothers.

      (Araujo and Bier, 2000)

      Expression of eaΔN in gd7 females (lack wild type ea activity) produces lateralised embryos. Further injection of eaΔN RNA transcripts into these embryos causes cells at all dorsal-ventral positions near the injection site to develop like the most ventral cell type - the mesoderm.

      (Misra et al., 1998)

      Double mutant combinations with eaD1 are strongly dorsalized.

      (Chasan et al., 1992)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer

      Mohler.

      Induced with: fs(1)M861.

      (Mohler, 1977)
      Comments
      Comments

      Approximate order of allelic severity, from weakest to strongest is: gd5 > gd1 > gd3 > gd6 > gd2 > gd4 > gd7 = gd8 = gd9 = gd10 = gd11 = gd12.

      (Konrad et al., 1988)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      References (48)