FB2026_02 , released June 18, 2026
Allele: Dmel\eaΔN
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General Information
Symbol
Dmel\eaΔN
Species
D. melanogaster
Name
FlyBase ID
FBal0031155
Feature type
allele
Associated gene
Dmel\ea
Associated Insertion(s)
Carried in Construct
P{eaΔN}
Key Links
Transgenic product class
inframe_deletion
(Chasan et al., 1992)
Mutagen
Nature of the Allele
Transgenic product class
inframe_deletion
(Chasan et al., 1992)
Mutagen
in vitro construct
(Smith and DeLotto, 1994, Chasan et al., 1992)
Progenitor genotype
Carried in construct
P{eaΔN}
Cytology
Description

Construct: Deletion of the N terminal domain between the end of the predicted signal sequence and the Ile residue that is the first amino acid of the catalytic domain.

(Chasan et al., 1992)
Allele components
Component
Use(s)
Encoded product / tool
ea
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Embryos laid by eaΔN females are weakly ventralised.

      (Chang and Morisato, 2002)

      Injection of eaΔN RNA into embryos lacking ea causes a lateralised phenotype.

      (Smith and DeLotto, 1994)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Other
      Statement
      Reference

      eaΔN, gd7 has embryo phenotype

      (Misra et al., 1998)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression in gd7 females (lack wild type ea activity) produces lateralised embryos. Further injection of eaΔN RNA transcripts into these embryos causes cells at all dorsal-ventral positions near the injection site to develop like the most ventral cell type - the mesoderm.

      (Misra et al., 1998)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Also synthetic RNA transcripts are generated by in vitro transcription and injected into the centre of 0-1 hour embryos.

      (Misra et al., 1998)

      Active ea proteolytically cleaves spz when coexpressed in conditioned cell culture fluid, a 12kD carboxy-terminal fragment is generated.

      (DeLotto and DeLotto, 1998)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      eaΔN
      eaΔN
      (Anderson et al., 1992)
      Name Synonyms
      Secondary FlyBase IDs
        References (9)