FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
Allele: Dmel\gd5
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General Information
Symbol
Dmel\gd5
Species
D. melanogaster
Name
FlyBase ID
FBal0005013
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Nature of the Allele
Progenitor genotype
Cytology
Description

No nucleotide change is detected in the protein coding sequence or the introns.

Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

0% of embryos derived from homozygous females have a class I phenotype (they are strongly dorsalised, lacking both ventral denticles and filzkorper), 2% have a class II phenotype (they lack ventral denticles but have filzkorper), 54% have a class III phenotype (they have ventral denticles) and 44% have a class H phenotype (they are phenotypically normal and hatch). 25% of embryos derived from gd5/Df(1)KA10 females have a class I phenotype, 44% have a class II phenotype, 31% have a class III phenotype and 0% have a class H phenotype.

Homozygous females produce less than 2% viable offspring. Transheterozygous combinations of gd mutations produce a range of cuticular phenotypes, ranging from cuticle only having dorsal characteristics, to cuticle having some ventral characteristics, such as ventral setal belts, depending on the alleles used. Some combinations of alleles complement each other. Homozygous gd5 females show temperature sensitivity in the amount of hatching, and the severity of their offspring's dorsalised phenotype.

94% of embryos derived from gd5/gd10 females hatch. 90% of embryos derived from gd1/gd5 females have a class III phenotype; ventral cuticle is reduced, but some ventral abdominal setal belt material is retained, the anterior midgut invagination and ventral furrow are reduced or absent, gut formation is abnormal and the tracheal pits are located closer to the ventral midline than normal. 75% of embryos derived from gd2/gd5 females have a class III phenotype, and 20% have a class II phenotype; embryos lack ventral cuticle, the filzkorper are present and increased amounts of cuticle show dorsal characteristics compared to wild-type.

Embryonic defects detectable at gastrulation.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer

Mohler.

Comments
Comments

Approximate order of allelic severity, from weakest to strongest is: gd5 > gd1 > gd3 > gd6 > gd2 > gd4 > gd7 = gd8 = gd9 = gd10 = gd11 = gd12.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (4)
Reported As
Symbol Synonym
fs(1)M1813-1697
gd5
Name Synonyms
Secondary FlyBase IDs
    References (6)