FlyBase Allele Report: Dmel\gd[10]

General Information

Symbol

Dmel\gd¹⁰

Species

D. melanogaster

Name

FlyBase ID

FBal0045768

Feature type

allele

Associated gene

Dmel\gd

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

amorphic allele - genetic evidence

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Ponomareff et al., 2001)

Mutagen

ethyl methanesulfonate

(Konrad et al., 1988)

Progenitor genotype

Cytology

Description

Nucleotide substitution: G1723A. Amino acid replacement: G469E.

(Ponomareff et al., 2001)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

X:11,985,964..11,985,964 [-]

Nucleotide change:

G11985964A

Reported nucleotide change:

G1723A

Amino acid change:

G469E | gd-PC; G472E | gd-PD; G469E | gd-PF

Reported amino acid change:

G469E

(Ponomareff et al., 2001)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

female sterile | recessive

(Konrad et al., 1988)

Phenotype Manifest In

filzkorper

(Ponomareff et al., 2001)

filzkorper (with Df(1)KA10)

(Ponomareff et al., 2001)

filzkorper (with gd^LF12)

(Ponomareff et al., 2001)

filzkorper (with gd^Li115)

(Ponomareff et al., 2001)

filzkorper (with gdⁿ²⁷)

(Ponomareff et al., 2001)

filzkorper (with gd^VM90)

(Ponomareff et al., 2001)

filzkorper (with gd^VO27)

(Ponomareff et al., 2001)

ventral denticle belt

(Ponomareff et al., 2001)

ventral denticle belt (with Df(1)KA10)

(Ponomareff et al., 2001)

ventral denticle belt (with gd^LF12)

(Ponomareff et al., 2001)

ventral denticle belt (with gd^Li115)

(Ponomareff et al., 2001)

ventral denticle belt (with gd^LQ4)

(Ponomareff et al., 2001)

ventral denticle belt (with gdⁿ²⁷)

(Ponomareff et al., 2001)

ventral denticle belt (with gd^VM90)

(Ponomareff et al., 2001)

ventral denticle belt (with gd^VO27)

(Ponomareff et al., 2001)

Detailed Description

Statement

Reference

100% of embryos derived from homozygous or gd¹⁰/Df(1)KA10 females have a class I phenotype (they are strongly dorsalised, lacking both ventral denticles and filzkorper).

(Ponomareff et al., 2001)

Transheterozygous combinations of gd mutations produce a range of cuticular phenotypes, ranging from cuticle only having dorsal characteristics, to cuticle having some ventral characteristics, such as ventral setal belts, depending on the alleles used. Some combinations of alleles complement each other.

(Konrad et al., 1988)

94% of embryos derived from gd⁵/gd¹⁰ females hatch.

(Konrad et al., 1988)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Injection of snk^Xa RNA partially rescues the dorsalised phenotype of embryos derived from gd¹⁰/gd¹⁰ females; 54% of cuticles show restoration of ventral structures and the gastrulation pattern is polarised.

(Ponomareff et al., 2001)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Complements

gd¹⁹⁰

(Ponomareff et al., 2001)

gd^LQ4

(Ponomareff et al., 2001)

gd^Lu119

(Ponomareff et al., 2001)

gd^TN124

(Ponomareff et al., 2001)

gd^p18

(Ponomareff et al., 2001)

Fails to complement

gd^LF12

(Ponomareff et al., 2001)

gd^Li115

(Ponomareff et al., 2001)

gd^VM90

(Ponomareff et al., 2001)

gd^VO27

(Ponomareff et al., 2001)

gdⁿ²⁷

(Ponomareff et al., 2001)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

The addition of wild-type gd from the paternal genome does not alter the frequency of hatching in embryos derived from gd¹/gd¹⁰ transheterozygotes, indicating that the requirement for gd is strictly maternal.

(Konrad et al., 1988)

Approximate order of allelic severity, from weakest to strongest is: gd⁵ > gd¹ > gd³ > gd⁶ > gd² > gd⁴ > gd⁷ = gd⁸ = gd⁹ = gd¹⁰ = gd¹¹ = gd¹².

(Konrad et al., 1988)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

fs(1)2090

(Konrad et al., 1988)

gd¹⁰

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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