FlyBase Allele Report: Dmel\gd[VM90]

General Information

Symbol

Dmel\gd^VM90

Species

D. melanogaster

Name

FlyBase ID

FBal0130271

Feature type

allele

Associated gene

Dmel\gd

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

amorphic allele - genetic evidence

Mutagen

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Ponomareff et al., 2001)

Mutagen

Progenitor genotype

Cytology

Description

717bp deletion overlapping the 5' end of gd.

(Ponomareff et al., 2001)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

X:11,987,324..11,988,041 [-]

Comment:

A deletion of 717bp, whose 3 prime endpoint lies between amino acids 104 and 122 (Figure 1, FBrf0139682). The annotated endpoints of the deletion are approximate. Position of mutation on reference sequence inferred by FlyBase curator based on author statement.

(Ponomareff et al., 2001)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

filzkorper

(Ponomareff et al., 2001)

filzkorper (with Df(1)KA10)

(Ponomareff et al., 2001)

filzkorper (with gd¹)

(Ponomareff et al., 2001)

filzkorper (with gd²)

(Ponomareff et al., 2001)

filzkorper (with gd⁶)

(Ponomareff et al., 2001)

filzkorper (with gd⁹)

(Ponomareff et al., 2001)

filzkorper (with gd¹⁰)

(Ponomareff et al., 2001)

ventral denticle belt

(Ponomareff et al., 2001)

ventral denticle belt (with Df(1)KA10)

(Ponomareff et al., 2001)

ventral denticle belt (with gd¹)

(Ponomareff et al., 2001)

ventral denticle belt (with gd²)

(Ponomareff et al., 2001)

ventral denticle belt (with gd⁶)

(Ponomareff et al., 2001)

ventral denticle belt (with gd⁹)

(Ponomareff et al., 2001)

ventral denticle belt (with gd¹⁰)

(Ponomareff et al., 2001)

Detailed Description

Statement

Reference

100% of embryos derived from homozygous or gd^VM90/Df(1)KA10 females have a class I phenotype (they are strongly dorsalised, lacking both ventral denticles and filzkorper).

(Ponomareff et al., 2001)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Enhancer of

Statement

Reference

gd^VM90/gd[+] is an enhancer | maternal effect of embryonic/first instar larval cuticle | maternal effect phenotype of pip⁷/pip²

(Zhang et al., 2009)

Additional Comments

Genetic Interactions

Statement

Reference

The severity of the dorsalisation phenotype seen in embryos derived from pip²/pip⁷ females is increased if the females are also carrying gd^VM90/+; 78.8% of embryos derived from the double mutant females are completely dorsalised, and none are only weakly dorsalised.

(Zhang et al., 2009)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

gd⁶

(Ponomareff et al., 2001)

gd²

(Ponomareff et al., 2001)

gd¹

(Ponomareff et al., 2001)