FlyBase Allele Report: Dmel\gd[9]

General Information

Symbol

Dmel\gd⁹

Species

D. melanogaster

Name

FlyBase ID

FBal0045771

Feature type

allele

Associated gene

Dmel\gd

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Konrad et al., 1988)

Progenitor genotype

Cytology

Description

Amino acid replacement: Q399term.

(Ponomareff et al., 2001)

Nucleotide substitution: C1512T.

(Ponomareff et al., 2001)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

X:11,986,175..11,986,175 [-]

Nucleotide change:

C11986175T

Reported nucleotide change:

C1512T

Amino acid change:

Q399term | gd-PC; Q402term | gd-PD; Q399term | gd-PF

Reported amino acid change:

Q399term

(Ponomareff et al., 2001)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

female sterile | recessive

(Konrad et al., 1988)

lethal - all die during embryonic stage | maternal effect

(DeLotto, 2001)

some die during embryonic stage | maternal effect

(DeLotto, 2001)

Phenotype Manifest In

filzkorper

(Ponomareff et al., 2001)

filzkorper (with Df(1)KA10)

(Ponomareff et al., 2001)

filzkorper (with gd¹⁹⁰)

(Ponomareff et al., 2001)

filzkorper (with gd^LF12)

(Ponomareff et al., 2001)

filzkorper (with gd^Li115)

(Ponomareff et al., 2001)

filzkorper (with gd^LQ4)

(Ponomareff et al., 2001)

filzkorper (with gd^Lu119)

(Ponomareff et al., 2001)

filzkorper (with gdⁿ²⁷)

(Ponomareff et al., 2001)

filzkorper (with gd^p18)

(Ponomareff et al., 2001)

filzkorper (with gd^TN124)

(Ponomareff et al., 2001)

filzkorper (with gd^VM90)

(Ponomareff et al., 2001)

filzkorper (with gd^VO27)

(Ponomareff et al., 2001)

ventral denticle belt

(Ponomareff et al., 2001)

ventral denticle belt (with Df(1)KA10)

(Ponomareff et al., 2001)

ventral denticle belt (with gd¹⁹⁰)

(Ponomareff et al., 2001)

ventral denticle belt (with gd^LF12)

(Ponomareff et al., 2001)

ventral denticle belt (with gd^Li115)

(Ponomareff et al., 2001)

ventral denticle belt (with gd^LQ4)

(Ponomareff et al., 2001)

ventral denticle belt (with gd^Lu119)

(Ponomareff et al., 2001)

ventral denticle belt (with gdⁿ²⁷)

(Ponomareff et al., 2001)

ventral denticle belt (with gd^p18)

(Ponomareff et al., 2001)

ventral denticle belt (with gd^TN124)

(Ponomareff et al., 2001)

ventral denticle belt (with gd^VM90)

(Ponomareff et al., 2001)

ventral denticle belt (with gd^VO27)

(Ponomareff et al., 2001)

Detailed Description

Statement

Reference

97% of embryos derived from homozygous females are dorsalised.

(DeLotto, 2001)

100% of embryos derived from homozygous or gd⁹/Df(1)KA10 females have a class I phenotype (they are strongly dorsalised, lacking both ventral denticles and filzkorper).

(Ponomareff et al., 2001)

Transheterozygous combinations of gd mutations produce a range of cuticular phenotypes, ranging from cuticle only having dorsal characteristics, to cuticle having some ventral characteristics, such as ventral setal belts, depending on the alleles used. Some combinations of alleles complement each other.

(Konrad et al., 1988)

70% of embryos derived from gd⁶/gd⁹ females have a class II phenotype; embryos lack ventral cuticle, the filzkorper are present and increased amounts of cuticle show dorsal characteristics compared to wild-type, embryos are more twisted than class III embryos and are often tube-like, the ventral furrow is absent, there is no sign of mesoderm development and midgut and hindgut is poorly organised. 30% have a class I phenotype; embryos lack ventral cuticle and filzkorper, producing only dorsal cuticle. Embryos derived from gd⁹/Df(1)KA10 females have a class I phenotype.

(Konrad et al., 1988)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Embryos derived from gd⁹/gd⁹ ; Spn27A^ex32/Df(2L)BSC7 females express either a dorsolateral or ventrolateral fate around their circumference.

(Ligoxygakis et al., 2003)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Approximate order of allelic severity, from weakest to strongest is: gd⁵ > gd¹ > gd³ > gd⁶ > gd² > gd⁴ > gd⁷ = gd⁸ = gd⁹ = gd¹⁰ = gd¹¹ = gd¹².

(Konrad et al., 1988)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

fs(1)1971

(Konrad et al., 1988)

fs(1)E1971

gd⁹

(Gomez et al., 2024, DeLotto, 2001)

Name Synonyms

Secondary FlyBase IDs

References (7)

Report Sections

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