FlyBase Allele Report: Dmel\gd[TN124]

General Information

Symbol

Dmel\gd^TN124

Species

D. melanogaster

Name

FlyBase ID

FBal0130272

Feature type

allele

Associated gene

Dmel\gd

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

hypomorphic allele - genetic evidence

Mutagen

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Ponomareff et al., 2001)

Mutagen

Progenitor genotype

Cytology

Description

Nucleotide substitution: C73T. Amino acid replacement: P25S.

(Ponomareff et al., 2001)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

X:11,987,614..11,987,614 [-]

Nucleotide change:

C11987614T

Reported nucleotide change:

C73T

Amino acid change:

P25S | gd-PC; P25S | gd-PD; P25S | gd-PE; P25S | gd-PF

Reported amino acid change:

P25S

(Ponomareff et al., 2001)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

filzkorper

(Ponomareff et al., 2001)

filzkorper (with Df(1)KA10)

(Ponomareff et al., 2001)

filzkorper (with gd¹)

(Ponomareff et al., 2001)

filzkorper (with gd²)

(Ponomareff et al., 2001)

filzkorper (with gd⁹)

(Ponomareff et al., 2001)

ventral denticle belt

(Ponomareff et al., 2001)

ventral denticle belt (with Df(1)KA10)

(Ponomareff et al., 2001)

ventral denticle belt (with gd¹)

(Ponomareff et al., 2001)

ventral denticle belt (with gd²)

(Ponomareff et al., 2001)

ventral denticle belt (with gd⁹)

(Ponomareff et al., 2001)

Detailed Description

Statement

Reference

22% of embryos derived from homozygous females have a class I phenotype (they are strongly dorsalised, lacking both ventral denticles and filzkorper), 49% have a class II phenotype (they lack ventral denticles but have filzkorper) and 29% have a class III phenotype (they have ventral denticles). 91% of embryos derived from gd^TN124/Df(1)KA10 females have a class I phenotype and 9% have a class II phenotype.

(Ponomareff et al., 2001)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions