FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term serine-type endopeptidase activity ID (Ontology) GO:0004252 (Gene Ontology)
Definition Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).
Comment
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Annotations
Records annotated with this term OR any of its CHILD TERMS

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Direct annotations: records annotated with this exact term (child terms are NOT included)
Data ClassFieldDirect annotations
Genes (FBgn)GO_MOLECULAR_FUNCTION
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 Full annotation statements 
Relevant FlyBase reports
 Gene Groups Genes
 serine-type endopeptidase activity (all annotations which use CV term, excluding "NOT" statements)
     enables | serine-type endopeptidase activity       --
 NOT | enables | serine-type endopeptidase activity       --
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Vocabulary search 
peptidase activity
 |__endopeptidase activity__________
 |__serine-type peptidase activity__|
serine hydrolase activity           |
 |__serine-type peptidase activity__|
                                    serine-type endopeptidase activity  229 rec.
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Is a endopeptidase activity
serine-type peptidase activity
Part of
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Synonyms
  • "blood coagulation factor activity" RELATED
    "serine elastase activity" RELATED
Secondary IDs
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EC:3.4.21.-
EC:3.4.21.1
EC:3.4.21.10
EC:3.4.21.102
EC:3.4.21.20
EC:3.4.21.21
EC:3.4.21.22
EC:3.4.21.26
EC:3.4.21.27
EC:3.4.21.34
EC:3.4.21.35
EC:3.4.21.36
EC:3.4.21.38
EC:3.4.21.39
EC:3.4.21.4
EC:3.4.21.41
EC:3.4.21.42
EC:3.4.21.43
EC:3.4.21.45
EC:3.4.21.46
EC:3.4.21.47
EC:3.4.21.48
EC:3.4.21.5
EC:3.4.21.53
EC:3.4.21.54
EC:3.4.21.59
EC:3.4.21.6
EC:3.4.21.61
EC:3.4.21.62
EC:3.4.21.68
EC:3.4.21.69
EC:3.4.21.7
EC:3.4.21.71
EC:3.4.21.73
EC:3.4.21.75
EC:3.4.21.78
EC:3.4.21.79
EC:3.4.21.83
EC:3.4.21.88
EC:3.4.21.9
EC:3.4.21.92
EC:3.4.21.93
EC:3.4.21.94
Reactome:R-HSA-114697 "Activated thrombin (factor IIa) cleaves PAR3,4, activating them"
Reactome:R-HSA-1181152 "Cleavage of NODAL proprotein"
Reactome:R-HSA-139893 "Granzyme-B activates BID by cleavage"
Reactome:R-HSA-140599 "factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides"
Reactome:R-HSA-140664 "prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst)"
Reactome:R-HSA-140696 "factor V -> factor Va + factor V activation peptide (thrombin catalyst)"
Reactome:R-HSA-140700 "prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst)"
Reactome:R-HSA-140736 "factor X -> factor Xa + factor X activation peptide (TF:F7a catalyst)"
Reactome:R-HSA-140769 "factor VII -> factor VIIa"
Reactome:R-HSA-140777 "factor X -> factor Xa + factor X activation peptide (TF:F7 catalyst)"
Reactome:R-HSA-140823 "factor IX -> factor IXa + factor IX activation peptide (TF:F7a catalyst)"
Reactome:R-HSA-140840 "fibrinogen -> fibrin monomer + 2 fibrinopeptide A + 2 fibrinopeptide B"
Reactome:R-HSA-140870 "thrombin:antithrombin III:heparin -> thrombin:cleaved antithrombin III:heparin"
Reactome:R-HSA-141026 "Activated protein C cleaves factor Va to factor Vi intermediate form"
Reactome:R-HSA-141040 "Activated thrombin:thrombomodulin cleaves PROCR:Protein C to PROCR:Activated protein C"
Reactome:R-HSA-1454843 "E-cadherin degradation by MMP3, MMP7 and plasmin"
Reactome:R-HSA-1474197 "Collagen type II degradation by MMP1,3,8,13,PRSS2"
Reactome:R-HSA-1566962 "Elastin degradation by elastin-degrading extracellular proteinases"
Reactome:R-HSA-1566979 "Laminin-332 degradation by laminin-322 degrading extracellular proteinases"
Reactome:R-HSA-1566981 "Fibronectin degradation by MMP1, 3, 7, 12, 13, 19, CTSS"
Reactome:R-HSA-158137 "factor VIII:von Willibrand factor multimer -> factor VIIIa + factor VIIIa B A3 acidic polypeptide + von Willibrand factor multimer"
Reactome:R-HSA-158164 "factor X -> factor Xa + factor X activation peptide (VIIIa:IXa catalyst)"
Reactome:R-HSA-158300 "factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (XIIa catalyst)"
Reactome:R-HSA-158311 "kallikrein:kininogen:C1q binding protein tetramer -> kallikrein + activated kininogen:C1q binding protein tetramer + bradykinin"
Reactome:R-HSA-158313 "factor XII -> factor XIIa"
Reactome:R-HSA-158333 "factor IX -> factor IXa + factor IX activation peptide (factor XIa catalyst)"
Reactome:R-HSA-158419 "factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (thrombin catalyst)"
Reactome:R-HSA-158744 "crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasmin"
Reactome:R-HSA-158747 "crosslinked fibrin multimer:tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain)"
Reactome:R-HSA-158750 "crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasmin"
Reactome:R-HSA-158766 "fibrin multimer, crosslinked -> fibrin digestion products (plasmin)"
Reactome:R-HSA-158925 "plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [two-chain] catalyst)"
Reactome:R-HSA-158942 "urokinase plasminogen activator (one-chain):uPAR -> urokinase plasminogen activator (two-chain):uPAR"
Reactome:R-HSA-158982 "plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [one-chain] catalyst)"
Reactome:R-HSA-1592270 "NID1 degradation by MMP1, 9, 12, ELANE"
Reactome:R-HSA-1592278 "Autocatalytic activation of proMMP2"
Reactome:R-HSA-1592297 "Full activation of MMP1"
Reactome:R-HSA-1592314 "HSPG2 (perlecan) degradation by MMP3, plasmin, (MMP12)"
Reactome:R-HSA-1592316 "Initial activation of proMMP1"
Reactome:R-HSA-1592362 "Activation of proMMP7 by MMP3"
Reactome:R-HSA-1592371 "Initial activation of proMMP3"
Reactome:R-HSA-1592398 "Activation of proMMP8"
Reactome:R-HSA-1592436 "Initial activation of proMMP9 by MMPs"
Reactome:R-HSA-159728 "Furin cleaves pro-prothrombin to prothrombin"
Reactome:R-HSA-159733 "Furin cleaves pro-factor X to factor X"
Reactome:R-HSA-159771 "Furin cleaves pro-protein C to protein C"
Reactome:R-HSA-159773 "Furin cleaves pro-protein S to protein S"
Reactome:R-HSA-159796 "Furin cleaves pro-factor IX to factor IX"
Reactome:R-HSA-159868 "Furin cleaves pro-factor VII to factor VII"
Reactome:R-HSA-1602458 "Activation of proMMP10"
Reactome:R-HSA-1602466 "Activation of MT-MMPs by FURIN"
Reactome:R-HSA-1602473 "Autocatalytic activation of MMP1"
Reactome:R-HSA-1602484 "Activation of proMMP11 by FURIN"
Reactome:R-HSA-1602488 "Initial activation of proMMP13 by plasmin and trypsin"
Reactome:R-HSA-1604359 "Initial activation of proMMP2 by MMP1, 7"
Reactome:R-HSA-1604360 "Initial activation of proMMP2 by MMP14"
Reactome:R-HSA-1604368 "Autocatalytic activation of bound proMMP2"
Reactome:R-HSA-1604690 "Activation of MMP9 intermediate form by MMPs"
Reactome:R-HSA-1604712 "Initial activation of proMMP7 by trypsin"
Reactome:R-HSA-1604722 "Activation of proMMP9 by proteases"
Reactome:R-HSA-1604731 "Autocatalytic activation of MMP3"
Reactome:R-HSA-1604732 "Autocatalytic activation of proMMP13"
Reactome:R-HSA-1604741 "Initial activation of proMMP13 by MMP14 (MT1-MMP)"
Reactome:R-HSA-1604752 "Initial activation of proMMP13 by MMP3"
Reactome:R-HSA-1604763 "Autocatalytic activation of MMP7"
Reactome:R-HSA-163798 "Furin cleaves pro-protein Z to protein Z"
Reactome:R-HSA-163843 "Furin cleaves pro-GAS6 to GAS6"
Reactome:R-HSA-1655842 "S1P hydrolyzes SREBP1A,1C,2"
Reactome:R-HSA-166753 "Conversion of C4 into C4a and C4b"
Reactome:R-HSA-166792 "Conversion of C2 into C2a and C2b"
Reactome:R-HSA-166817 "Cleavage of C3 by C3 convertases"
Reactome:R-HSA-170844 "Latent TGF-beta-1 is cleaved by FURIN"
Reactome:R-HSA-171288 "Cleavage of the viral Env gp160 precursor polyprotein"
Reactome:R-HSA-173626 "Activation of C1r"
Reactome:R-HSA-173631 "Activation of C1s"
Reactome:R-HSA-173680 "Activation of C5"
Reactome:R-HSA-173745 "Factor D cleaves C3(H2O)-bound Factor B"
Reactome:R-HSA-174551 "Formation of alternative pathway C5 convertase"
Reactome:R-HSA-1799329 "Signal peptidase hydrolyzes signal peptide from ribosome-associated nascent protein"
Reactome:R-HSA-183122 "Factor D cleaves C3b-bound Factor B"
Reactome:R-HSA-183130 "C3(H2O):Factor Bb cleaves C3 to C3b and C3a"
Reactome:R-HSA-186785 "PDGF-AA clevage by Furin"
Reactome:R-HSA-187020 "Part of pro-beta-NGF is processed to mature beta-NGF"
Reactome:R-HSA-1912369 "NOTCH precursor cleaved to form mature NOTCH"
Reactome:R-HSA-1912372 "Fringe-modified Pre-NOTCH is cleaved by FURIN"
Reactome:R-HSA-2022411 "Cathepsin G hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-32) (Angiotensin-(1-8))"
Reactome:R-HSA-2129357 "Fibrillin C-terminal processing"
Reactome:R-HSA-2168923 "Collagen type XVIII endostatin release"
Reactome:R-HSA-2168960 "Collagen type XVII ectodomain shedding"
Reactome:R-HSA-2172405 "Collagen type XXIII ectodomain shedding"
Reactome:R-HSA-2214330 "Cleavage of collagen VII NC2 region by BMP1"
Reactome:R-HSA-2471621 "Endostatin degradation by cathepsins"
Reactome:R-HSA-2471842 "Collagen type XXV ectomain shedding"
Reactome:R-HSA-2482180 "Collagen type VIII degradation by ELANE"
Reactome:R-HSA-2514772 "Fibrillin-1 degradation by MMP3, CTSK, CTSL2"
Reactome:R-HSA-2514823 "Fibrillin-1 degradation by ELANE"
Reactome:R-HSA-2534160 "HSPG2 (perlecan) degradation by MMP13, CTSS"
Reactome:R-HSA-2534206 "E-cadherin degradation by PS1:NCSTN (Gamma-secretase)"
Reactome:R-HSA-2534260 "E-cadherin degradation by caspase-3 and calpain-1"
Reactome:R-HSA-265301 "Corticotropin cleavage from POMC"
Reactome:R-HSA-3244626 "DENV protease NS2B3 cleaves STING"
Reactome:R-HSA-3266557 "Factor I cleaves iC3b"
Reactome:R-HSA-3785684 "Fibronectin degradation by CTSG"
Reactome:R-HSA-3788061 "Fibronectin degradation by ADAM8"
Reactome:R-HSA-381135 "MBTPS1 (S1P) cleaves ATF6 (ATF6-alpha)"
Reactome:R-HSA-381446 "Thrombin proteolyzes IGF:IGFBP3:ALS"
Reactome:R-HSA-381461 "Plasmin proteolyzes IGF:IGFBP-3:ALS"
Reactome:R-HSA-381466 "Prostate-specific Antigen proteolyzes IGF:IGFBP3:ALS"
Reactome:R-HSA-3814820 "HSPG2 (perlecan) is cleaved by BMP1, TLL1, TLL2, Cathepsin L1"
Reactome:R-HSA-381500 "Cathepsin G proteolyzes IGF:IGFBP3:ALS"
Reactome:R-HSA-381798 "PCSK1 hydrolyzes Proglucagon to Glucagon-like Peptide-1"
Reactome:R-HSA-382061 "Extracellular processing of novel PDGFs"
Reactome:R-HSA-3928657 "MMP2,9 cleave EPHB"
Reactome:R-HSA-400459 "Signal peptidase hydrolyzes preproGLP-1 to proGLP-1"
Reactome:R-HSA-400492 "PCSK1 hydrolyzes proGIP to GIP"
Reactome:R-HSA-400496 "Signal peptidase hydrolyzes preproGIP to proGIP"
Reactome:R-HSA-422021 "PCSK1 hydrolyzes acyl Proghrelin to acyl Ghrelin"
Reactome:R-HSA-422051 "Cleavage of the signal peptide of Preproghrelin"
Reactome:R-HSA-5210912 "Furin cleaves ANTXR2-bound pagA to yield pagA(197-794)"
Reactome:R-HSA-5210935 "Furin cleaves ANTXR1-bound pagA to yield pagA(197-794)"
Reactome:R-HSA-5578783 "CORIN(802-1042) hydrolyses NPPA to form NPPA(124-151)"
Reactome:R-HSA-5591040 "Activated protein C cleaves Factor Va intermediate form for Factor Va"
Reactome:R-HSA-5607002 "Activated protein C cleaves factor VIIIa"
Reactome:R-HSA-5691512 "APEH hydrolyses NAc-Ser-protein"
Reactome:R-HSA-6800198 "HPN heterodimer cleaves pro-MST1 to form MST1 dimer"
Reactome:R-HSA-6800200 "HPN heterodimer cleaves pro-HGF to form HGF dimer"
Reactome:R-HSA-6800299 "HGFAC cleaves pro-HGF to form HGF dimer"
Reactome:R-HSA-6801687 "PRTN3 cleaves CAMP(31-170) to generate CAMP(134-170)"
Reactome:R-HSA-6807224 "Furin cleaves pro-BGLAP to BGLAP"
Reactome:R-HSA-8849826 "ST14 hydrolyzes and activates KLK5"
Reactome:R-HSA-8849857 "KLK5 cleaves and activates CELA2"
Reactome:R-HSA-8850831 "KLK5 cleaves and activates KLK8"
Reactome:R-HSA-8852716 "Thrombin, ELANE cleave C5"
Reactome:R-HSA-8855825 "HTRA1 hydrolyzes ACAN (Aggrecan)"
Reactome:R-HSA-8865275 "PDGF-BB clevage by Furin"
Reactome:R-HSA-8865276 "PDGF-AB clevage by Furin"
Reactome:R-HSA-8874145 "MBTPS1 (S1P) cleaves ATF6B (ATF6-beta)"
Reactome:R-HSA-8874186 "MBTPS1 (S1P) cleaves CREB3L4"
Reactome:R-HSA-8874204 "MBTPS1 (S1P) cleaves CREB3"
Reactome:R-HSA-8874205 "MBTPS1 (S1P) cleaves CREB3L2"
Reactome:R-HSA-8874206 "MBTPS1 (S1P) cleaves CREB3L3"
Reactome:R-HSA-8874212 "MBTPS1 (S1P) cleaves CREB3L1"
Reactome:R-HSA-9023178 "PCSK2 cleaves Insulin(57-110) to yield Insulin(90-110) and C-peptide (Insulin(57-89))"
Reactome:R-HSA-9023196 "PCSK1 cleaves proinsulin to yield Insulin(25-56) and Insulin(57-110)"
Reactome:R-HSA-9023626 "DPP4(39-766) hydrolyzes Glucose-dependent Insulinotropic Polypeptide (GIP)"
Reactome:R-HSA-9023627 "DPP4(1-766) hydrolyzes Glucose-dependent Insulinotropic Polypeptide (GIP)"
Reactome:R-HSA-9023632 "DPP4(39-766) hydrolyzes Glucagon-like Peptide-1 (GLP-1)"
Reactome:R-HSA-9023633 "DPP4(1-766) hydrolyzes Glucagon-like Peptide-1 (GLP-1)"
Reactome:R-HSA-9033490 "TYSND1 cleaves PHYH"
Reactome:R-HSA-9033506 "TYSND1 cleaves AGPS"
Reactome:R-HSA-9033515 "TYSND1 cleaves ACOX1"
Reactome:R-HSA-9033520 "TYSND1 cleaves TYSND1"
Reactome:R-HSA-9033524 "TYSND1 cleaves SCP2"
Reactome:R-HSA-9033529 "TYSND1 cleaves ACAA1"
Reactome:R-HSA-9033530 "TYSND1 cleaves HSD17B4"
Reactome:R-HSA-9653249 "Cleavage of factor XII variant by activated thrombin"
Reactome:R-HSA-9655046 "Cleavage of FXII variant by KLKB1"
Reactome:R-HSA-9662786 "FURIN cleaves ADAM17"
Reactome:R-HSA-9666383 "F8 variant is not cleaved by thrombin"
Reactome:R-HSA-9668253 "Hyperactivation of factor X by FVIIIa:FIXa R384L"
Reactome:R-HSA-9668365 "FVIIIa variant:FIXa does not convert FX to the active FXa"
Reactome:R-HSA-9670874 "FIXa variant:FVIIIa does not convert FX to the active FXa"
Reactome:R-HSA-9673223 "FIX(29-461) variant is not activated (factor XIa catalyst)"
Reactome:R-HSA-9686710 "Cleavage of S protein into S1:S2"
Reactome:R-HSA-9686731 "TMPRSS2 Mediated SARS-CoV-1 Spike Protein Cleavage and Endocytosis"
Reactome:R-HSA-9694287 "Cleavage of S protein into S1:S2"
Reactome:R-HSA-9694661 "TMPRSS2 Mediated SARS-CoV-2 Spike Protein Cleavage and Endocytosis"
Reactome:R-HSA-9698988 "Direct Host Cell Membrane Membrane Fusion and Release of SARS-CoV-2 Nucleocapsid"
Reactome:R-HSA-9699007 "FURIN Mediated SARS-CoV-2 Spike Protein Cleavage and Endocytosis"
Reactome:R-HSA-9708859 "Activated thrombin (factor IIa) cleaves F2R (PAR1), activating it"
Reactome:R-HSA-9710106 "ELANE cleaves GSDMD"
Reactome:R-HSA-9710263 "GZMB cleaves GSDME"
Reactome:R-HSA-976743 "Factor I inactivates plasma Factor H-bound C3b"
Reactome:R-HSA-9769949 "FURIN Mediated SARS-CoV-2 Spike Protein Cleavage"
Reactome:R-HSA-9770187 "S2 Cleavage by TMPRSS2 Exposes S2' Initiating Cell-Cell Fusion"
Reactome:R-HSA-977371 "Factor I inactivates Factor H-boundC3b"
Reactome:R-HSA-977615 "Factor I inactivates MCP/CR1-bound C4b/C3b"
Reactome:R-HSA-9816275 "CDH1 is proteolytically cleaved in Golgi"
Reactome:R-HSA-9829030 "Nascent F signal peptide is cleaved at ER membrane"
Reactome:R-HSA-9829200 "F0 is cleaved, releasing F1, F2, F(110-136)"
Reactome:R-HSA-9830805 "Nascent sG localizes to ER lumen, gets glycosylated"
Reactome:R-HSA-9830882 "Nascent G signal peptide is cleaved at ER membrane"
Reactome:R-HSA-9839367 "TGFBR3_mem cleavage by MMPs"
Reactome:R-HSA-9911236 "ELANE cleaves NOTCH2NLA"
Reactome:R-HSA-9911383 "LepB cleaves prepro-STa"
Reactome:R-HSA-9912368 "LepB cleaves pre-EltA"
Reactome:R-HSA-9912371 "LepB cleaves pre-EltB"
Reactome:R-HSA-9913329 "Autoproteolysis of DAG1 to alpha and beta chains"
Reactome:R-HSA-9918772 "Dengue polyprotein cis-auto-cleaves"
Reactome:R-HSA-9918780 "Unknown peptidase cleaves NS1-NS2A"
Reactome:R-HSA-9918787 "NS2B3 cleaves C-prM-E-NS1-NS2A"
Reactome:R-HSA-9918795 "Signalase cleaves prM-E-NS1-NS2A"
Reactome:R-HSA-9918813 "NS2B3 cleaves NS4AB"
Reactome:R-HSA-9918817 "NS2B3 cleaves polyprotein"
Reactome:R-HSA-9918823 "NS345:NS2B cleaves NS345"
Reactome:R-HSA-9918871 "Signalase cleaves prepro-NS4B"
Reactome:R-HSA-9918876 "NS2B3 cleaves prepro-C at the C-prM junction"
Reactome:R-HSA-9919050 "Furin cleaves prM:E"
Reactome:R-HSA-9921595 "NS2B3 cleaves FAM134B"
Reactome:R-HSA-9921689 "NS3 cleaves GrpEL1"
Reactome:R-HSA-9926936 "EspC(54-1018) cleaves hemoglobin"
Reactome:R-HSA-9926963 "Hbp cis-autocleaves"
Reactome:R-HSA-9927009 "Hbp(53-1100) cleaves hemoglobin"
Reactome:R-HSA-9932162 "Removal of CDH1 signal peptide"
Reactome:R-HSA-9947496 "ACOT2 cleaves NS345"