FlyBase Allele Report: Dmel\gd[8]

General Information

Symbol

Dmel\gd⁸

Species

D. melanogaster

Name

FlyBase ID

FBal0005016

Feature type

allele

Associated gene

Dmel\gd

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Konrad et al., 1988)

Progenitor genotype

Cytology

Description

Amino acid replacement: Q450term.

(Ponomareff et al., 2001)

Nucleotide substitution: C1665T.

(Ponomareff et al., 2001)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

X:11,986,022..11,986,022 [-]

Nucleotide change:

C11986022T

Reported nucleotide change:

C1665T

Amino acid change:

Q450term | gd-PC; Q453term | gd-PD; Q450term | gd-PF

Reported amino acid change:

Q450term

(Ponomareff et al., 2001)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

female sterile | recessive

(Konrad et al., 1988)

lethal - all die during embryonic stage | maternal effect

(Konrad et al., 1998)

some die during embryonic stage | maternal effect

(Konrad et al., 1998)

Phenotype Manifest In

embryo

(Drier et al., 2000)

filzkorper

(Ponomareff et al., 2001)

filzkorper (with Df(1)KA10)

(Ponomareff et al., 2001)

ventral denticle belt

(Ponomareff et al., 2001)

ventral denticle belt (with Df(1)KA10)

(Ponomareff et al., 2001)

Detailed Description

Statement

Reference

100% of embryos derived from homozygous or gd⁸/Df(1)KA10 females have a class I phenotype (they are strongly dorsalised, lacking both ventral denticles and filzkorper).

(Ponomareff et al., 2001)

Homozygous gd⁸ embryos are completely dorsalised.

(Drier et al., 2000)

Bacterially challenged mutants exhibit a wild type Drs response. Pattern of response of CecA1 and CecA2 parallels that of Drs. Dpt and Dro remain fully inducible and pattern of expression of AttA and Def in intermediate.

(Lemaitre et al., 1996)

Injection of snk^Δne.T:ea into the central region of homozygous embryos causes a lateralised/ventralised phenotype.

(Smith and DeLotto, 1994)

Transheterozygous combinations of gd mutations produce a range of cuticular phenotypes, ranging from cuticle only having dorsal characteristics, to cuticle having some ventral characteristics, such as ventral setal belts, depending on the alleles used. Some combinations of alleles complement each other.

(Konrad et al., 1988)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Other

Statement

Reference

dl^S234P, gd⁸ has embryo phenotype

(Drier et al., 2000)

dl^unspecified, gd⁸ has embryo phenotype

(Drier et al., 2000)

Additional Comments

Genetic Interactions

Statement

Reference

One copy of dl^S234P in a gd⁸ background produces dorsalised embryos. The addition of dl^S234P in a dl^unspecified, gd⁸ background, produces completely lateralised embryos.

(Drier et al., 2000)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

gd⁸ is rescued by gd^+t9.3

(Konrad et al., 1998)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Approximate order of allelic severity, from weakest to strongest is: gd⁵ > gd¹ > gd³ > gd⁶ > gd² > gd⁴ > gd⁷ = gd⁸ = gd⁹ = gd¹⁰ = gd¹¹ = gd¹².

(Konrad et al., 1988)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

fs(1)gd^MED

(Konrad et al., 1988)

gd⁸

(Minakhina et al., 2003)

gd^MED

Name Synonyms

Secondary FlyBase IDs

FBal0045772

References (11)

Report Sections

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