FlyBase Allele Report: Dmel\dl[unspecified]

General Information

Symbol

Dmel\dl^unspecified

Species

D. melanogaster

Name

FlyBase ID

FBal0086656

Feature type

allele

Associated gene

Dmel\dl

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Cytology

Description

FlyBase curator comment: this entry is used to capture phenotypic information when the particular allele (or allele combination) used by the author could not be determined but the context of the experiment suggests that the phenotype being described is some kind of loss of function.

(FlyBase Curators, 2025-)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

embryo

(Drier et al., 2000)

embryo | ventral

(Tearle and Nusslein-Volhard, 1987)

Detailed Description

Statement

Reference

Embryos derived from homozygous females are dorsalised. Embryos show a dominant haplo-insufficient temperature sensitive phenotype of partial dorsalisation.

(Tearle and Nusslein-Volhard, 1987)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Enhanced by

Statement

Reference

dl^unspecified has embryonic epidermis phenotype, enhanceable by Taf1^S-625

(Pham and Sauer, 2000)

dl^unspecified has embryonic/first instar larval cuticle phenotype, enhanceable by Taf1^S-625

(Pham and Sauer, 2000)

dl^unspecified has embryonic epidermis phenotype, enhanceable by Taf1^XS-2232

(Pham and Sauer, 2000)

dl^unspecified has embryonic/first instar larval cuticle phenotype, enhanceable by Taf1^XS-2232

(Pham and Sauer, 2000)

Other

Statement

Reference

dl^unspecified, gd⁸ has embryo phenotype

(Drier et al., 2000)

Additional Comments

Genetic Interactions

Statement

Reference

The addition of dl^S234P in a dl^unspecified, gd⁸ double null background, produces completely lateralised embryos.

(Drier et al., 2000)

When Taf1^XS-2232 or Taf1^S-625 is added to dl^unspecified/+ sensitized embryos they exhibit a dorsalised and twisted body pattern.

(Pham and Sauer, 2000)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

dl^unspecified is rescued by dl^25.Venus

(Reeves et al., 2012)

dl^unspecified is rescued by dl^+mWT

(Drier et al., 2000)

dl^unspecified is rescued by dl^+mWT

(Drier et al., 1999)

dl^unspecified is rescued by dl^S79A

(Drier et al., 1999)

dl^unspecified is rescued by dl^T290V

(Drier et al., 1999)

dl^unspecified is rescued by dl^T85A

(Drier et al., 1999)

dl^unspecified is rescued by dl^Y324F

(Drier et al., 1999)

dl^unspecified is rescued by dl^Hsp83.PG

(Govind, 1996)

Partially rescued by

dl^unspecified is partially rescued by dl^S103A

(Drier et al., 1999)

dl^unspecified is partially rescued by dl^S213A

(Drier et al., 1999)

dl^unspecified is partially rescued by dl^S312A

(Drier et al., 1999)

dl^unspecified is partially rescued by dl^S317A

(Drier et al., 1999)

dl^unspecified is partially rescued by dl^S70A

(Drier et al., 1999)

Not rescued by

dl^unspecified is not rescued by dl^ΔNLS

(Drier et al., 2000)

dl^unspecified is not rescued by dl^6XS-A

(Drier et al., 1999)

dl^unspecified is not rescued by dl^ΔNLS.Hsp83

(Govind et al., 1996)

Comments

Addition of dl^+mWT into a dl^unspecified null background rescue of the dorsalisation phenotype seen in dl^unspecified embryos. Addition of dl^ΔNLS into a homozygous dl^unspecified null background leads to embryos that are strongly, but not completely dorsalised. If a single copy of dl^ΔNLS is inserted into heterozygous dl^unspecified females, they were sterile and produced weakly dorsalised embryos. One copy of dl^S234P in a dl^unspecified null background produces lateralised embryos.

(Drier et al., 2000)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

dl^unspecified

Name Synonyms

Secondary FlyBase IDs

References (10)

Report Sections

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