FlyBase Gene Report: Dmel\teq

General Information

Symbol

Dmel\teq

Species

D. melanogaster

Name

Tequila

Annotation Symbol

CG4821

Feature Type

protein_coding_gene

FlyBase ID

FBgn0023479

Gene Model Status

Current

Stock Availability

11 publicly available

Enzyme Name (EC)

Gene Summary

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Gene Group
Interactive Fly

Also Known As

graal, SP72

Key Links

Genomic Location

Cytogenetic map

66F4-66F5

Sequence location

3L:9,074,643..9,092,131 [+]

Recombination map

3-28

RefSeq locus

NT_037436 REGION:9074643..9092131

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (9 terms)

Molecular Function (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

enables chitin binding

inferred from electronic annotation with InterPro:IPR002557, InterPro:IPR036508

(InterPro Project Members, 2004-)

enables serine-type endopeptidase activity

inferred from electronic annotation with InterPro:IPR001254, InterPro:IPR018114

(InterPro Project Members, 2004-)

inferred from sequence model

(Cao and Jiang, 2018, Ross et al., 2003)

Biological Process (5 terms)

Terms Based on Experimental Evidence (4 terms)

CV Term

Evidence

References

involved_in glucose homeostasis

inferred from mutant phenotype

(Huang et al., 2015)

involved_in long-term memory

inferred from mutant phenotype

(Chen et al., 2012, Didelot et al., 2006)

involved_in positive regulation of insulin secretion

inferred from mutant phenotype

(Huang et al., 2015)

involved_in short-term memory

inferred from direct assay

(Colomb et al., 2009)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

involved_in proteolysis

inferred from sequence model

(Ross et al., 2003)

inferred from electronic annotation with InterPro:IPR001254, InterPro:IPR018114

(InterPro Project Members, 2004-)

Cellular Component (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

located_in extracellular region

inferred from electronic annotation with InterPro:IPR002557

(InterPro Project Members, 2004-)

located_in membrane

inferred from electronic annotation with InterPro:IPR001190, InterPro:IPR036772

(InterPro Project Members, 2004-)

Gene Group (FlyBase)

S1A SERINE PROTEASES - TRYPSIN-LIKE

CHITIN BINDING DOMAIN-CONTAINING PROTEINS

Protein Family (UniProt)

Protein Signatures (InterPro)

Catalytic Activity (EC/Rhea)

serine-type endopeptidase activity

Summaries

Gene Group (FlyBase)

S1A SERINE PROTEASES - TRYPSIN-LIKE -: Trypsin-like serine proteases of the S1A family are endopeptidases that cleave amide substrates following Arginine or Lysine at the P1 position. (Adapted from FBrf0239469).
CHITIN BINDING DOMAIN-CONTAINING PROTEINS -: Chitin binding domains are found in certain classes of chitin binding proteins and chitin-active enzymes. (Adapted from FBrf0108362.)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\teq for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9VSU2)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.48

Gene model reviewed during 5.45

Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.

Gene model reviewed during 5.55

Mutation in sequenced strain: insertion of transposon.

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

teq-RC

FBtr0076527

NM_168315

2263

563

teq-RD

FBtr0076525

NM_168314

4602

1450

teq-RF

FBtr0344980

NM_001169922

7389

2379

teq-RG

FBtr0344981

NM_140031

8628

2792

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

teq-PC

FBpp0076254

62.0

563

7.64

FBpp0076252

160.1

1450

6.42

FBpp0311235

264.0

2379

6.54

FBpp0311236

309.1

2792

6.41

Q9VSU2

NP_648288

AAF50319

Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

MEROPS - An information resource for peptidases (also termed proteases, proteinases and proteolytic enzymes) and the proteins that inhibit them.

S01.950

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\teq using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Tequila_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.96

Transcript Expression

expression microarray

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

eye

(Xu et al., 2004)

Additional Descriptive Data

Eye-enriched transcripts determined by ratio of expression level in wild-type heads. versus expression level in so heads.

(Xu et al., 2004)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

neuron | subset of adult brain

(Chen et al., 2012)

neuron of the dorsal anterior lateral group of the protocerebrum

(Chen et al., 2012)

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\teq in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\teq

View exonic expression by tissue for Dmel\teq

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

39048/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0023479

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0023479

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0023479

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG4821

Flygut - An atlas of the Drosophila adult midgut

FBgn0023479

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 6 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 9 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of teq

Transgenic constructs containing regulatory region of teq

Aberrations (Deficiencies and Duplications) ( 3 )

Inferred from experimentation ( 3 )

Gene disrupted in

Df(3L)29A6

(Munier et al., 2004)

Df(3L)Exel6113

(Ryder, 2004.4.26)

Df(3L)Rdl-2

(Munier et al., 2004)

Inferred from location ( 6 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

partially lethal - majority die, with Scer\GAL4^pnr-MD237

teq^GD4757

viable

viable, with Scer\GAL4^da.G32

teq^{UAS.Tag:SS(Drs)}

viable, with Scer\GAL4^Mef2.PR

teq^GD4757

viable, with Scer\GAL4^yolk

teq^{UAS.Tag:SS(Drs)}

Sterility

Allele

fertile

teq^f01792

Other Phenotypes

Allele

abnormal feeding behavior

teq^f01792

abnormal feeding behavior | RU486 conditional, with Scer\GAL4^{Mef2.247.Switch}

teq^RNAi.UAS

abnormal memory

teq^f01792

abnormal memory, with Scer\GAL4^238Y

teq^RNAi.UAS

abnormal memory, with Scer\GAL4⁵¹²²

teq^RNAi.UAS

abnormal memory, with Scer\GAL4^G0431

teq^RNAi.UAS

abnormal memory, with Scer\GAL4^Mef2.247

teq^RNAi.UAS

abnormal memory | adult stage

teq^f01792

abnormal memory | RU486 conditional, with Scer\GAL4^{Mef2.247.Switch}

teq^RNAi.UAS

abnormal oxidative stress response | adult stage | male | chemical conditional

teq^f01792

abnormal starvation stress response | adult stage

teq^f01792

decreased body size | adult stage

teq^f01792

long lived

teq^f01792

long lived, with Scer\GAL4^elav.PU

teq^GD4757

long lived, with Scer\GAL4^Ilp2.PU

teq^GD4757

long lived | RU486 conditional, with Scer\GAL4^{elav.Switch.PO}

teq^GD4757

short lived, with Scer\GAL4^ppl.PU

teq^GD4757

short lived | female, with Scer\GAL4^Ilp2.PU

teq^UAS.D

some die during pupal stage, with Scer\GAL4^pnr-MD237

teq^GD4757

Phenotype manifest in

Allele

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (129)

Hsap\PRSS12

7 of 14

Yes

Hsap\SSC4D

4 of 14

Yes

Hsap\CD5L

3 of 14

Yes

Hsap\CD163

2 of 14

Yes

Hsap\CD163L1

2 of 14

Hsap\DMBT1

2 of 14

Yes

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\CFD

1 of 14

Hsap\CFI

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

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1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

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1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

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1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\RPP25

1 of 14

Hsap\RPP25L

1 of 14

Hsap\SCARA5

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

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Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (89)

Rnor\Prss12

7 of 14

Yes

Rnor\Ssc4d

4 of 14

Yes

Rnor\Cd5l

3 of 14

Yes

Rnor\Cd163

2 of 14

Yes

Rnor\LOC100911413

2 of 14

Yes

Rnor\Olr292

2 of 14

Yes

Rnor\Scart1

2 of 14

Yes

Rnor\Ssc5d

2 of 14

Yes

Rnor\Tmprss11a

2 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

Yes

Rnor\Tmprss11f

2 of 14

Yes

Rnor\Tmprss11g

2 of 14

Rnor\Acr

1 of 14

Rnor\C1r

1 of 14

Yes

Rnor\C1s

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Rnor\Masp2

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

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1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Mus musculus (laboratory mouse) (110)

Mmus\Prss12

6 of 14

Yes

Mmus\Ssc4d

4 of 14

Yes

Mmus\Cd5l

2 of 14

Yes

Mmus\Scart1

2 of 14

Yes

Mmus\Scart2

2 of 14

Yes

Mmus\Ssc5d

2 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mmus\C1rb

1 of 14

Yes

Mmus\C1s1

1 of 14

Yes

Mmus\C1s2

1 of 14

Yes

Mmus\Cd163

1 of 14

Yes

Mmus\Cdcp3

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

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1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mmus\Masp2

1 of 14

Mmus\Msr1

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

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1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (83)

Xtro\prss12

5 of 13

Yes

Xtro\ssc4d

5 of 13

Yes

Xtro\cd163

3 of 13

Yes

Xtro\dmbt1

3 of 13

Yes

Xtro\f12

2 of 13

Yes

Xtro\hgfac

2 of 13

Yes

Xtro\LOC101733428

2 of 13

Yes

Xtro\LOC101733498

2 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\efcab7

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

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1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\XB5723326

1 of 13

Xtro\XB5892359

1 of 13

Danio rerio (Zebrafish) (96)

Drer\si:ch73-127m5.1

7 of 14

Yes

Drer\si:ch211-51a6.2

7 of 14

Yes

Drer\prss12

6 of 14

Yes

Drer\LOC560447

4 of 14

Yes

Drer\si:dkey-21h14.9

3 of 14

Yes

Drer\si:ch211-161n3.3

2 of 14

Yes

Drer\si:dkey-14d8.20

2 of 14

Yes

Drer\si:dkey-21h14.8

2 of 14

Yes

Drer\cela1.1

1 of 14

Drer\cela1.6

1 of 14

Drer\cfi

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\LOC100331291

1 of 14

Drer\LOC100331436

1 of 14

Yes

Drer\LOC100536376

1 of 14

Yes

Drer\LOC101885301

1 of 14

Yes

Drer\LOC108183287

1 of 14

Yes

Drer\LOC108183379

1 of 14

Yes

Drer\LOC108183380

1 of 14

Yes

Drer\LOC108183587

1 of 14

Yes

Drer\LOC110437838

1 of 14

Yes

Drer\LOC110437843

1 of 14

Yes

Drer\LOC110438623

1 of 14

Yes

Drer\LOC110438628

1 of 14

Yes

Drer\LOC110438629

1 of 14

Yes

Drer\LOC110439311

1 of 14

Yes

Drer\LOC110439348

1 of 14

Yes

Drer\LOC110439349

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Drer\si:dkey-238d18.3

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

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1 of 14

1 of 14

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1 of 14

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1 of 14

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (23)

Cele\svh-1

6 of 14

Yes

Cele\try-1

2 of 14

Cele\C31G12.4

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Cele\F15H9.1

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Cele\Y116A8A.6

1 of 14

Yes

Anopheles gambiae (African malaria mosquito) (329)

Agam\SCRASP1

9 of 12

Yes

Agam\AgaP_AGAP011615

2 of 12

Yes

2 of 12

2 of 12

1 of 12

1 of 12

1 of 12

1 of 12

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1 of 12

1 of 12

1 of 12

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

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1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

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1 of 12

1 of 12

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1 of 12

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1 of 12

1 of 12

1 of 12

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1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

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1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (3)

Atha\AT1G20220

1 of 13

Yes

Atha\AT1G76010

1 of 13

Yes

Atha\AT3G07030

1 of 13

Yes

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:teq. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (279)

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

mas

2 of 13

ndl

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

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1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

flz

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

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1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

MP1

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

psh

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

snk

1 of 13

Sp7

1 of 13

SPE

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

tpr

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 1 )

Human Ortholog

Disease

Evidence

References

PRSS12; serine protease 12

model of autosomal recessive intellectual developmental disorder 1

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

PRSS12; serine protease 12

7 of 14

606709

INTELLECTUAL DEVELOPMENTAL DISORDER, AUTOSOMAL RECESSIVE 1; MRT1

autosomal recessive intellectual developmental disorder 1

SSC4D; scavenger receptor cysteine rich family member with 4 domains

4 of 14

607639

CD5L; CD5 molecule like

3 of 14

602592

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

RNA-protein

Physical Interaction

Assay

References

teq - orb2

pull down, western blot

(Khan et al., 2015, Majumdar et al., 2012, Mastushita-Sakai et al., 2010)

protein-protein

Physical Interaction

Assay

References

teq - Drep2

anti tag coimmunoprecipitation, peptide massfingerprinting

(Andlauer et al., 2014)

Summary of Genetic Interactions

Interaction Browsers

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

64448

DroID - A comprehensive database of gene and protein interactions.

FBgn0023479

MIST (protein-protein) - An integrated Molecular Interaction Database

39048

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-28

Cytogenetic map

66F4-66F5

Sequence location

3L:9,074,643..9,092,131 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

66F4-66F5

Limits computationally determined from genome sequence between P{PZ}l(3)01629⁰¹⁶²⁹&P{PZ}mRpL12¹⁰⁵³⁴ and P{EP}Hsp26^EP3336&P{EP}Hsp26^EP3315

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

66F-67A

(determined by in situ hybridisation)

(Munier et al., 2004)

Experimentally Determined Recombination Data

Location

3-28

(FlyBase, 2016)

3-21.4

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (11)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

18473

w¹¹¹⁸; PBac{WH}teq^f01792

41896

y¹ v¹; P{TRiP.GL01328}attP40

22832

y¹ w^67c23; Mi{ET1}teq^MB00537

42650

y¹ sc^* v¹ sev²¹; P{TRiP.HMS02486}attP2

4821R-1

4821R-3

4948R-1

HMJ21264

y¹ v¹; P{TRiP.HMJ21264}attP40

HMS02486

y¹ sc^* v¹ sev²¹; P{TRiP.HMS02486}attP2

VDRC

v15362

w¹¹¹⁸ P{GD4757}v15362

v45232

w¹¹¹⁸; P{GD4757}v45232

Genomic Clones (12)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (52)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0023479

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0023479

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

One of 42 Drosophila genes identified as being most likely to reveal molecular and cellular mechanisms of nervous system development or plasticity relevant to human Mental Retardation disorders.

(Inlow and Restifo, 2004)

Identification: cDNA screen for secreted and transmembrane proteins expressed during embryogenesis.

(Kopczynski et al., 1998)

Relationship to Other Genes

Source for database merge of

Source for merge of: Tequila graal CG18403 CG4948

(Bayraktaroglu, 2000.8.7)

Source for merge of: Tequila anon- EST:ParkEST161

(Bayraktaroglu, 2000.11.2)

Source for merge of: Tequila BEST:CK00198 BEST:GH18038

(Rana, 2004.7.8)

Additional comments

Annotations CG4821, CG4948 and CG18153 merged as CG4821 (which corresponds to Tequila) in release 3 of the genome annotation.

(FlyBase Genome Annotators, 2002-2003)

Release 1 annotation CG18403 corresponds to part of the r3.2 annotation for Tequila (CG4821).

(FlyBase, 1996-)

Nomenclature History

Source for database identify of

Source for identity of: teq Tequila

(Didelot et al., 2006)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (14)

Reported As

Symbol Synonym

BEST:CK00198

BEST:GH18038

CG18153

(Luschnig, 2003.12.17)

CG18403

(Munier et al., 2004)

CG4821

(Andlauer et al., 2014, Christis and Munro, 2012, Ni et al., 2010.12.1, Zhang et al., 2010, Shah et al., 2008, Hollien and Weissman, 2006, Wertheim et al., 2005)

CG4948

(Yang et al., 2005, Munier et al., 2004, Xu et al., 2004)

CK00198

(Kopczynski et al., 1998)

SP72

(Cao and Jiang, 2018, Ross et al., 2003)

Teq

(Zatsepina et al., 2022, Araki et al., 2020, Staats et al., 2018, Huang et al., 2015, Ashton-Beaucage et al., 2010, Preat et al., 2007, Sonderegger and Patthy, 2007, Didelot, 2006, Didelot et al., 2006)

anon-EST:ParkEST161

graal

(Munier et al., 2004, Lagueux, 2001.3.24, Lagueux, 1999.12.30)

teq

(Knop et al., 2025, Gatti et al., 2024, Deolankar et al., 2022, Kumar et al., 2021, Etges, 2019, Mathew et al., 2017, Zhang et al., 2015, Zhang et al., 2014, Plaçais and Preat, 2013, Colomb et al., 2009, Didelot et al., 2006)

Name Synonyms

CG4948

(Yang et al., 2005)

Tequila

(Nakano et al., 2023, Cao and Jiang, 2018, Mathew et al., 2017, Andlauer et al., 2014, Pankotai et al., 2013, Guan et al., 2011, Ashton-Beaucage et al., 2010, Allen and Spradling, 2008, Shah et al., 2008, Lai et al., 2007, Preat et al., 2007, Sonderegger and Patthy, 2007, Didelot et al., 2006, Rollmann et al., 2006, Lipatov et al., 2005)

tequila

(Mohr et al., 2017, Zhang et al., 2015, Plaçais and Preat, 2013, Winbush et al., 2012, Colomb et al., 2009, Krashes and Waddell, 2008)

Secondary FlyBase IDs

FBgn0025714
FBgn0026292
FBgn0029083
FBgn0035961
FBgn0035962
FBgn0035963
FBgn0043819

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 84 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

39048

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9VSU2

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9VSU2

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

39048/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0023479

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0023479

FlyMine - An integrated database for Drosophila genomics

FBgn0023479

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG4821

MARRVEL_MODEL - MARRVEL (model organism gene)

39048

MEROPS - An information resource for peptidases (also termed proteases, proteinases and proteolytic enzymes) and the proteins that inhibit them.

S01.950

Linkouts

BioGRID - A database of protein and genetic interactions.

64448

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0023479

DroID - A comprehensive database of gene and protein interactions.

FBgn0023479

DRSC - Results frm RNAi screens

FBgn0023479

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Tequila_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0023479

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0023479

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG4821

Flygut - An atlas of the Drosophila adult midgut

FBgn0023479

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC015110

MIST (protein-protein) - An integrated Molecular Interaction Database

39048

References (108)

The following external sites may use different assemblies or annotations than FlyBase.

-0.96

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