FlyBase Gene Report: Dmel\Jon25Bi

General Information

Symbol

Dmel\Jon25Bi

Species

D. melanogaster

Name

Jonah 25Bi

Annotation Symbol

CG8867

Feature Type

protein_coding_gene

FlyBase ID

FBgn0020906

Gene Model Status

Current

Stock Availability

37 publicly available

Enzyme Name (EC)

Gene Summary

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Gene Group
Interactive Fly

Also Known As

Ser4, Jon25B, SP137

Key Links

Genomic Location

Cytogenetic map

25B4-25B4

Sequence location

2L:4,954,279..4,955,144 [-]

Recombination map

2-14

RefSeq locus

NT_033779 REGION:4954279..4955144

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (6 terms)

Molecular Function (3 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

enables serine hydrolase activity

inferred from high throughput direct assay

(Kumar et al., 2021)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

enables endopeptidase activity

inferred from sequence model

(Ross et al., 2003)

enables serine-type endopeptidase activity

inferred from electronic annotation with InterPro:IPR001254

(InterPro Project Members, 2004-)

inferred from electronic annotation with InterPro:IPR001254, InterPro:IPR018114

(InterPro Project Members, 2004-)

inferred from sequence model

(Cao and Jiang, 2018)

Biological Process (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

involved_in innate immune response

inferred from biological aspect of ancestor with PANTHER:PTN000667087

(GO Reference Genome Project, 2011-)

involved_in proteolysis

inferred from electronic annotation with InterPro:IPR001254

(InterPro Project Members, 2004-)

inferred from electronic annotation with InterPro:IPR001254, InterPro:IPR018114

(InterPro Project Members, 2004-)

inferred from sequence model

(Ross et al., 2003)

Cellular Component (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

is_active_in extracellular space

inferred from biological aspect of ancestor with PANTHER:PTN000667087

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

S1A SERINE PROTEASES - ELASTASE-LIKE

Protein Family (UniProt)

Protein Signatures (InterPro)

Catalytic Activity (EC/Rhea)

serine-type endopeptidase activity

Summaries

Gene Group (FlyBase)

S1A SERINE PROTEASES - ELASTASE-LIKE -: Elastase-like serine proteases cleave substrates following an alanine at the P1 position. (Adapted from FBrf0239469). Elastase-like serine proteases of the S1A family are endopeptidases that cleave substrates following an alanine at the P1 position. (Adapted from FBrf0239469).

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Jon25Bi for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9VMX7)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.44

Gene model reviewed during 5.45

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Jon25Bi-RB

FBtr0100432

NM_001038784

866

266

Additional Transcript Data and Comments

Reported size (kB)

0.8 (northern blot)

(Ahrens and Mahoney, 1998)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Jon25Bi-PB

FBpp0099851

28.7

266

6.29

Q9VMX7

NP_001033873

ABC65872

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

265 (aa); 29 (kD predicted)

(Ahrens and Mahoney, 1998)

Comments

The putative signal sequence and mRNA expression in the gut suggest

the Jon25Bi protein may be secreted into the larval gut and may have a digestive role.

(Ahrens and Mahoney, 1998)

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

MEROPS - An information resource for peptidases (also termed proteases, proteinases and proteolytic enzymes) and the proteins that inhibit them.

S01.950

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Jon25Bi using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Jon25Bi_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.38

Transcript Expression

northern blot

Stage

Tissue/Position (including subcellular localization)

Reference

third instar larval stage

larval digestive system | restricted

(Ahrens and Mahoney, 1998)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Jon25Bi in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Jon25Bi

View exonic expression by tissue for Dmel\Jon25Bi

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0020906

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

33708/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0020906

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0020906

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0020906

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG8867

Flygut - An atlas of the Drosophila adult midgut

FBgn0020906

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 1 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 7 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Jon25Bi

Transgenic constructs containing regulatory region of Jon25Bi

Aberrations (Deficiencies and Duplications) ( 2 )

Inferred from experimentation ( 2 )

Gene disrupted in

Df(2L)Exel7021

(Ryder, 2004.4.26)

Df(2L)Exel8012

(Ryder, 2004.4.26)

Inferred from location ( 8 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Jon25Bi^GD5245

viable, with Scer\GAL4^Mef2.PR

Jon25Bi^GD5245

viable, with Scer\GAL4^pnr-MD237

Jon25Bi^GD5245

Other Phenotypes

Allele

visible, with Scer\GAL4^pnr-MD237

Jon25Bi^GD5245

Phenotype manifest in

Allele

trichogen cell, with Scer\GAL4^pnr-MD237

Jon25Bi^GD5245

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (76)

Hsap\CTRB1

3 of 14

Yes

Hsap\CTRB2

3 of 14

Yes

Hsap\CTRC

3 of 14

Yes

Hsap\CTRL

3 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (63)

Rnor\Ctrc

3 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Mus musculus (laboratory mouse) (74)

Mmus\Ctrl

3 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (85)

Xtro\cela1.2

2 of 13

Yes

Xtro\cfd

2 of 13

Yes

Xtro\f7

2 of 13

Yes

Xtro\gzma

2 of 13

Yes

Xtro\LOC548809

2 of 13

Yes

Xtro\LOC100491119

2 of 13

Yes

Xtro\LOC100495541

2 of 13

Yes

Xtro\LOC101731336

2 of 13

Yes

Xtro\LOC101734670

2 of 13

Yes

Xtro\LOC108647852

2 of 13

Yes

Xtro\LOC108648818

2 of 13

Yes

Xtro\LOC116407662

2 of 13

Yes

Xtro\LOC116411715

2 of 13

Yes

Xtro\pafah1b3

2 of 13

Yes

Xtro\prss8

2 of 13

Yes

Xtro\prss27

2 of 13

Yes

Xtro\prss29

2 of 13

Yes

Xtro\prss56

2 of 13

Yes

Xtro\tmprss6

2 of 13

Yes

Xtro\tmprss13

2 of 13

Yes

Xtro\tpsg1

2 of 13

Yes

Xtro\XB5892359

2 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\cela3a

1 of 13

Yes

Xtro\corin

1 of 13

Xtro\ctrb1

1 of 13

Yes

Xtro\ctrb2

1 of 13

Yes

Xtro\ctrc

1 of 13

Yes

Xtro\ctrl

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\LOC100489516

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\LOC101734343

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\LOC116412122

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Xtro\prss8l.5 loc108703873

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Danio rerio (Zebrafish) (64)

Drer\cela1.1

3 of 14

Yes

Drer\cela1.2

3 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

Yes

Drer\ctrb.2

2 of 14

Drer\ctrb.3

2 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Drer\si:dkey-238d18.3

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (14)

Cele\try-4

3 of 14

Yes

Cele\try-5

3 of 14

Yes

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (204)

Agam\AgaP_AGAP004741

10 of 12

Yes

Agam\AgaP_AGAP010240

8 of 12

Agam\AgaP_AGAP006385

5 of 12

Agam\AgaP_AGAP005704

4 of 12

Yes

Agam\AgaP_AGAP005706

4 of 12

Yes

Agam\AgaP_AGAP005707

4 of 12

Yes

Agam\AgaP_AGAP006677

4 of 12

Yes

4 of 12

3 of 12

3 of 12

3 of 12

Yes

Agam\AgaP_AGAP005703

3 of 12

Yes

Agam\AgaP_AGAP005705

3 of 12

Yes

Agam\AgaP_AGAP005708

3 of 12

Yes

Agam\AgaP_AGAP006672

3 of 12

Yes

Agam\AgaP_AGAP006673

3 of 12

Agam\AgaP_AGAP006675

3 of 12

Agam\AgaP_AGAP006676

3 of 12

Yes

3 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

Yes

Agam\AgaP_AGAP005587

2 of 12

Yes

Agam\AgaP_AGAP005591

2 of 12

Yes

Agam\AgaP_AGAP005592

2 of 12

Yes

Agam\AgaP_AGAP005593

2 of 12

Yes

Agam\AgaP_AGAP005594

2 of 12

Yes

Agam\AgaP_AGAP005596

2 of 12

Yes

Agam\AgaP_AGAP005597

2 of 12

Yes

Agam\AgaP_AGAP005598

2 of 12

Yes

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

Yes

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

Yes

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (0)

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Jon25Bi. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (198)

12 of 13

12 of 13

11 of 13

11 of 13

11 of 13

11 of 13

11 of 13

11 of 13

11 of 13

11 of 13

11 of 13

11 of 13

10 of 13

10 of 13

10 of 13

9 of 13

9 of 13

8 of 13

8 of 13

8 of 13

8 of 13

8 of 13

7 of 13

7 of 13

7 of 13

7 of 13

7 of 13

6 of 13

6 of 13

6 of 13

4 of 13

4 of 13

4 of 13

4 of 13

4 of 13

4 of 13

4 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

MP1

3 of 13

psh

3 of 13

snk

3 of 13

SPE

3 of 13

3 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

Sp7

2 of 13

sphe

2 of 13

tpr

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

flz

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

teq

1 of 13

θTry

1 of 13

Try29F

1 of 13

ζTry

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 3 )

Human Ortholog

Disease

Evidence

References

CTRC; chymotrypsin C

model of pancreatitis

IEA

(FlyBase, 2019-)

PRSS2; serine protease 2

model of pancreatitis

IEA

(FlyBase, 2019-)

PRSS1; serine protease 1

model of pancreatitis

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

CTRB1; chymotrypsinogen B1

3 of 14

118890

CTRB2; chymotrypsinogen B2

3 of 14

619620

CTRC; chymotrypsin C

3 of 14

601405

PANCREATITIS, HEREDITARY; PCTT

pancreatitis

CTRL; chymotrypsin like

3 of 14

118888

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

Summary of Genetic Interactions

Interaction Browsers

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

59893

DroID - A comprehensive database of gene and protein interactions.

FBgn0020906

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-14

Cytogenetic map

25B4-25B4

Sequence location

2L:4,954,279..4,955,144 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

25B4-25B4

Limits computationally determined from genome sequence between P{lacW}l(2)k10004^k10004&P{EP}CG3036^EP963 and P{PZ}l(2)05714⁰⁵⁷¹⁴

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

56E3-56E3

(Ahrens, 1997.6.3)

56E3-56E3

(determined by in situ hybridisation)

(Ahrens and Mahoney, 1998)

25B-25B

(determined by in situ hybridisation)

(Carlson and Hogness, 1985)

Experimentally Determined Recombination Data

Location

2-14

(FlyBase, 2016)

2-16.0

(Comeron et al., 2012)

(Ahrens, 1997.6.3)

2-[13]

(Lindsley and Zimm, 1992)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (37)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

42484

y¹ v¹; P{TRiP.GL01343}attP40

92002

y¹ w^*; P{org-1.SM-RFP}Jon25Bi^18a

44025

y¹ sc^* v¹ sev²¹; P{TRiP.HMS02740}attP2

603846

y¹ w^*; P{org-1.SM-RFP}Jon25Bi^18a P{tinC-GFP}cn^13b P{HLH54F.LVM-RFP}16c

603845

y¹ w^*; P{org-1.SM-RFP}Jon25Bi^18a P{tinC-GFP}cn^13b P{HLH54F.LVM-RFP}Sin3A^16b

603854

y¹ w^*; P{org-1.SM-RFP}Jon25Bi^18a mib2^S1259 P{tinC-GFP}cn^13b P{HLH54F.LVM-RFP}16c

NIG-Fly

8867R-2

P{NIG.8867R}2

HMS02740

y¹ sc^* v¹ sev²¹; P{TRiP.HMS02740}attP2

2LG-1517

y² VhaAC39-1^cho-1 v¹; P{U6-Jon25Bi.NIG.sgRNA.1}attP40/CyO

2LG-3207

y² VhaAC39-1^cho-1 v¹; P{U6-Jon25Bi.NIG.sgRNA.2}attP40/CyO

VDRC

v106877

P{KK111014}VIE-260B

v37937

w¹¹¹⁸; P{GD5245}v37937/TM3

More stocks available...

Genomic Clones (12)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (29)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

RE01906

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0020906

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0020906

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R⁺ cell morphology.

(Kiger et al., 2003)

Jon25Bi has been cloned and sequenced.

(Ahrens and Mahoney, 1998)

Relationship to Other Genes

Source for database merge of

Source for merge of: Jon25Bi Ser4

(Schaeffer, 2004.1.1)

Additional comments

Nomenclature History

Source for database identify of

Source for identity of: Ser4 CG8867

(Kodira, 1999.11)

Nomenclature comments

Etymology

One of a number of genes isolated from a cDNA library made from third instar salivary glands, but subsequently found not to be expressed in the salivary glands but instead expressed specifically and abundantly in the midgut (which resulted in contamination of the original cDNA library). This surprising discovery prompted the name "Jonah" for this family of genes, after the Biblical prophet who unexpectedly turned up in the gut.

(Carlson and Hogness, 1985)

Synonyms and Secondary IDs (11)

Reported As

Symbol Synonym

25B

(Akam and Carlson, 1985)

CG8867

(National Institute of Genetics Fly Stocks, 2022-, Çiçek et al., 2016, Ni et al., 2010.12.1, Parisi et al., 2010, Keleman et al., 2009.8.5, Haussmann et al., 2008, Shah et al., 2008, Kambris et al., 2006, De Gregorio et al., 2001)

Jon25

(Brown et al., 2014)

Jon25B

(Lindsley and Zimm, 1992)

Jon25Bi

(Knop et al., 2025, Huang et al., 2024, Fisher et al., 2023, Bonfini et al., 2021, Gruntenko et al., 2021, Kumar et al., 2021, Zhou et al., 2021, Cao and Jiang, 2018, Yang et al., 2017, Mossman et al., 2016, Hollfelder et al., 2014, Short and Lazzaro, 2013, Japanese National Institute of Genetics, 2012.5.21, Fernández-Ayala et al., 2010, Shah et al., 2008)

Jon25i

(Yurkevych et al., 2020)

SP137

(Cao and Jiang, 2018, Ross et al., 2003)

Ser4

(Shah et al., 2008, Roxstrom-Lindquist et al., 2004, De Gregorio et al., 2002, Hwang et al., 2001, Ahrens and Mahoney, 1998)

Name Synonyms

Jonah 25B

(Schaeffer, 2004.1.1)

Jonah 25Bi

(Mossman et al., 2016, Kalajdzic et al., 2012, Carpenter et al., 2009, McGraw et al., 2008, Schaeffer, 2004.1.1)

Serine protease 4

Secondary FlyBase IDs

FBgn0001284
FBtr0079054
FBpp0078690

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 40 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

33708

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9VMX7

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9VMX7

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0020906

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

33708/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0020906

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0020906

FlyMine - An integrated database for Drosophila genomics

FBgn0020906

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG8867

MARRVEL_MODEL - MARRVEL (model organism gene)

33708

MEROPS - An information resource for peptidases (also termed proteases, proteinases and proteolytic enzymes) and the proteins that inhibit them.

S01.950

Linkouts

BioGRID - A database of protein and genetic interactions.

59893

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0020906

DroID - A comprehensive database of gene and protein interactions.

FBgn0020906

DRSC - Results frm RNAi screens

FBgn0020906

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Jon25Bi_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0020906

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0020906

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG8867

Flygut - An atlas of the Drosophila adult midgut

FBgn0020906

References (65)

The following external sites may use different assemblies or annotations than FlyBase.

-0.38

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