FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
CV Term Report
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General Information
Term endopeptidase activity ID (Ontology) GO:0004175 (Gene Ontology)
Definition Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain.
Comment
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Annotations
Records annotated with this term OR any of its CHILD TERMS
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Records annotated with this exact term (annotations to child terms are NOT included)
Data Class Field Records
Genes (FBgn)  GO_MOLECULAR_FUNCTION      28
show Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
 Full annotation statements 
Relevant FlyBase reports
 Genes
 endopeptidase activity (all annotations which use CV term, excluding "NOT" statements)      28
     enables | endopeptidase activity      28
Spanning Tree (Parents/Children)
Only view relationship: 
hydrolase activity_______________________
catalytic activity, acting on a protein__|
                                         peptidase activity
                                          |__endopeptidase activity  366 rec.
                                              |__aspartic-type endopeptidase activity 29 rec.
                                              |   |__aspartic endopeptidase activity, intramembrane cleaving 4 rec.
                                              |__cysteine-type endopeptidase activity 30 rec.
                                              |   |__calcium-dependent cysteine-type endopeptidase activity 4 rec.
                                              |   |__GPI-anchor transamidase activity 3 rec.
                                              |   |__ubiquitin-like protein-specific endopeptidase activity(+) 2 rec.
                                              |__glutamic-type endopeptidase activity
                                              |__metalloendopeptidase activity 64 rec.
                                              |   |__metalloendopeptidase activity involved in amyloid precursor protein catabolic process
                                              |__oligopeptidase activity 3 rec.
                                              |__peptidoglycan endopeptidase activity
                                              |   |__peptidoglycan cross-bridge peptide endopeptidase activity
                                              |   |__peptidoglycan stem peptide endopeptidase activity
                                              |__serine-type endopeptidase activity 224 rec.
                                              |__signal peptidase activity 8 rec.
                                              |__threonine-type endopeptidase activity 17 rec.
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Is a peptidase activity
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Synonyms
  • "elastase activity" RELATED
    "endoprotease activity" NARROW
    "proteasome endopeptidase activity" NARROW
    "proteinase" NARROW
Secondary IDs
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EC:3.4.99.-
Reactome:R-HSA-1168640 "Ubiquitinated IkB is degraded"
Reactome:R-HSA-1234159 "Proteasome proteolyzes ub-HIF-alpha"
Reactome:R-HSA-1236935 "Proteasomal cleavage of substrate (26S proteasome catalyst)"
Reactome:R-HSA-1236970 "Proteasomal clevage of exogenous antigen (26S proteasome catalyst)"
Reactome:R-HSA-1251997 "Cleavage of ERBB4m80 by gamma-scretase complex"
Reactome:R-HSA-1433374 "Processing of SCF isoform 1"
Reactome:R-HSA-1504193 "Ubiquitinated DVL is degraded by the proteasome"
Reactome:R-HSA-174058 "Degradation of multiubiquitinated Cdh1"
Reactome:R-HSA-174105 "Degradation of multiubiquitinated cell cycle proteins"
Reactome:R-HSA-174202 "Degradation of multiubiquitinated Securin"
Reactome:R-HSA-174203 "SCF-mediated degradation of Emi1"
Reactome:R-HSA-174255 "Degradation multiubiquitinated Cyclin A"
Reactome:R-HSA-180573 "Degradation of ubiquitinated CD4"
Reactome:R-HSA-180603 "Proteosome-mediated degradation of APOBEC3G"
Reactome:R-HSA-187574 "Degradation of ubiquitinated p27/p21 by the 26S proteasome"
Reactome:R-HSA-188191 "APC/C:Cdh1-mediated degradation of Skp2"
Reactome:R-HSA-193682 "gamma-secretase cleaves the p75NTR transmembrane domain"
Reactome:R-HSA-209061 "Ubiquitinated and phosphorylated IKBA binds to and is degraded by the proteasome complex"
Reactome:R-HSA-211715 "Proteasome mediated degradation of PAK-2p34"
Reactome:R-HSA-2130282 "Degradation of ubiquitinated beta catenin by the proteasome"
Reactome:R-HSA-2213200 "Release of endostatin-like peptides"
Reactome:R-HSA-264458 "Proteasome mediated degradation of COP1"
Reactome:R-HSA-353125 "26S proteosome degrades ODC holoenzyme complex"
Reactome:R-HSA-3640874 "Ub-RibC-AXIN is degraded by the proteasome"
Reactome:R-HSA-3928656 "gamma-secretase cleaves EPHB2"
Reactome:R-HSA-450466 "AUF1:mRNA complex is destroyed"
Reactome:R-HSA-4608855 "PRICKLE1 is degraded by the proteasome"
Reactome:R-HSA-4641256 "Ubiquitinated AXIN is degraded by the proteasome"
Reactome:R-HSA-4641260 "Ubiquitinated DVL1 is degraded by the proteasome"
Reactome:R-HSA-5358340 "Autoproteolytic cleavage of Hh precursors"
Reactome:R-HSA-5358460 "HPE SHH variants don't undergo autoproteolytic cleavage"
Reactome:R-HSA-5362448 "Hh C-terminal fragments are degraded by the proteasome"
Reactome:R-HSA-5387392 "processing defective Hh variants are degraded by the proteasome"
Reactome:R-HSA-5607724 "26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex"
Reactome:R-HSA-5607731 "26S proteasome processes p-7S-p100:RELB to form p52:RELB"
Reactome:R-HSA-5610754 "GLI3 is partially degraded by the proteasome to yield the GLI3 repressor"
Reactome:R-HSA-5610757 "GLI2 is degraded by the proteasome"
Reactome:R-HSA-5610758 "GLI1 is degraded by the proteasome after ubiquitination by beta-TrCP"
Reactome:R-HSA-5610760 "GLI1 is degraded by the proteasome after ubiquitination by ITCH"
Reactome:R-HSA-5635854 "GLI2,3 are degraded by the proteasome"
Reactome:R-HSA-5635868 "ub-GLI is degraded by the proteasome"
Reactome:R-HSA-5658430 "NF1 is degraded by the proteasome"
Reactome:R-HSA-5668481 "Protesomal degradation of K48polyUb-TRAF3"
Reactome:R-HSA-5668520 "26Sproteasome degrades K48polyUb-NIK"
Reactome:R-HSA-5687112 "MAPK6 is degraded by the 26S proteasome"
Reactome:R-HSA-5693081 "FURIN cleaves 7K-BACE1 to 7K-BACE1(46-501)"
Reactome:R-HSA-6784628 "PCSK6,FURIN mediate dissociation of 2 x LPL from GPIHBP1:HSPG:LPL dimer"
Reactome:R-HSA-6784676 "PCSK5 mediates dissociation of 2 x LPL from GPIHBP1:HSPG:LPL dimer"
Reactome:R-HSA-68825 "Ubiquitinated geminin is degraded by the proteasome"
Reactome:R-HSA-68948 "Ubiquitinated Orc1 is degraded by the proteasome"
Reactome:R-HSA-69016 "Ubiquitinated Cdc6 is degraded by the proteasome"
Reactome:R-HSA-69600 "Proteolytic degradation of ubiquitinated-Cdc25A"
Reactome:R-HSA-74730 "Insulin degradation"
Reactome:R-HSA-75825 "Proteasome mediated degradation of Cyclin D1"
Reactome:R-HSA-8849797 "Membrane proteases cleave Profilaggrin producing Filaggrin"
Reactome:R-HSA-8850992 "Proteasome degrades polyubiquitinated PTEN"
Reactome:R-HSA-8852354 "GTSE1 facilitates proteasome-mediated degradation of TP53"
Reactome:R-HSA-8854044 "Proteasome degrades AURKA ubiquitinated by SCF-FBXL7"
Reactome:R-HSA-8854071 "Proteasome-mediated degradation of PolyUb-FBXL7"
Reactome:R-HSA-8866553 "misfolded CFTR is degraded by the 26S proteasome"
Reactome:R-HSA-8866858 "CFTR F508del is degraded by the 26S proteasome"
Reactome:R-HSA-8932355 "26S proteasome degrades Ub-NFE2L2"
Reactome:R-HSA-8934819 "Cytoplasmic proteases cleave Profilaggrin producing Filaggrin"
Reactome:R-HSA-8939801 "26S proteasome degrades PolyUb-RUNX2"
Reactome:R-HSA-8952408 "Polyubiquitinated RUNX3 is degraded by the proteasome"
Reactome:R-HSA-8957265 "26S proteasome degrades TP73 polyubiquitinated by ITCH"
Reactome:R-HSA-9008110 "Proteasome degrades polyubiquitinated RUNX2"
Reactome:R-HSA-9009362 "Proteasome degrades PolyUb-RUNX2"
Reactome:R-HSA-9010096 "Gamma-secretase cleaves APP(672-770) to APP(672-711) and APP(672-713)"
Reactome:R-HSA-9011313 "Proteasome degrades ubiquitinated ROBO3.1"
Reactome:R-HSA-9604642 "Proteasome degrades ubiquitinated NICD4"
Reactome:R-HSA-9614271 "Autocleavage of ADGRG6"
Reactome:R-HSA-9755303 "26S proteasome degrades HIFalpha"
Reactome:R-HSA-9755306 "ub UBXN7 is degraded by the 26S proteasome"
Reactome:R-HSA-9762096 "Ub,pS335,S338,T NFE2L2 is degraded"
Reactome:R-HSA-983150 "Proteasomal cleavage of substrate"
Reactome:R-HSA-983158 "Trimming of peptides in ER"
Reactome:R-HSA-9839376 "TGFBR3(784-851) degradation"
Reactome:R-HSA-9906017 "Unknown peptidase cleaves UQCRFS1 subunit"
Reactome:R-HSA-9908101 "Maturation of the canonical 20S core particle"
Reactome:R-HSA-9908105 "Maturation of the 20S immunoproteasome core particle"
Reactome:R-HSA-9908108 "Maturation of the 20S thymoproteasome core particle"
Reactome:R-HSA-9908780 "Maturation of the preholospermatoproteasome"